PMID- 31244692 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20231012 IS - 1664-0640 (Print) IS - 1664-0640 (Electronic) IS - 1664-0640 (Linking) VI - 10 DP - 2019 TI - Evaluation of the Combined Treatment Approach "Robin" (Standardized Manual and Smartphone App) for Adolescents at Clinical High Risk for Psychosis. PG - 384 LID - 10.3389/fpsyt.2019.00384 [doi] LID - 384 AB - Introduction: The prevention of schizophrenia and other psychotic disorders has led researchers to focus on early identification of individuals at clinical high risk (CHR) for psychosis and to treat the at-risk symptoms in the pre-psychotic period. Although at-risk symptoms such as attenuated hallucinations or delusions are common in adolescents and associated with a marked reduction in global functioning, the evidence base of effective interventions for adolescents at CHR state and even fi rst-episode psychosis is limited. Thus, the present protocol describes a study design that combines therapy modules for CHR adolescents with a smartphone application supporting the young individuals between the therapy sessions. The treatment approach "Robin" is based on existing therapy strategies for adolescents with first episode of psychosis and the available recommendations for adults with at-risk symptoms. Methods: The evaluation aims firstly to compare the efficacy of Robin in 30 CHR adolescents aged 14-18 to an active control group (treatment as usual) from a previous study. Primary outcome measures will be at-risk symptomatology, comorbid diagnosis, functioning, self-efficacy, and quality of life. For the prospective intervention condition (16 weekly individual sessions + a minimum 4 family sessions), help-seeking adolescents with CHR for psychosis, aged 14-18, will be recruited over 3 years. At-risk and comorbid symptoms, functioning, self-efficacy, and quality of life are monitored at six time points (baseline, during the treatment period; immediately after intervention; and 6, 12, and 24 months later) and compared with the respective measures of the active control group. Discussion: To the best of our knowledge, this is the first controlled trial to test the efficacy of a specific early psychosis treatment in combination with a smartphone application for adolescents at CHR for developing psychosis. The results of the study are expected to add information that may substantially decrease the burden of CHR adolescents and increase their resilience. It may offer age-adapted and targeted strategies to guide clinicians in the treatment of these vulnerable individuals. Furthermore, research in the field of early intervention will be enriched by our findings. Clinical Trial Registration: www.ClinicalTrials.gov, identifier NCT03829527. FAU - Traber-Walker, Nina AU - Traber-Walker N AD - Department of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry, University of Zurich, Zurich, Switzerland. AD - The Zurich Program for Sustainable Development of Mental Health Services (ZInEP), University Hospital of Psychiatry Zurich, Zurich, Switzerland. FAU - Gerstenberg, Miriam AU - Gerstenberg M AD - Department of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry, University of Zurich, Zurich, Switzerland. AD - The Zurich Program for Sustainable Development of Mental Health Services (ZInEP), University Hospital of Psychiatry Zurich, Zurich, Switzerland. FAU - Metzler, Sibylle AU - Metzler S AD - Department of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry, University of Zurich, Zurich, Switzerland. AD - The Zurich Program for Sustainable Development of Mental Health Services (ZInEP), University Hospital of Psychiatry Zurich, Zurich, Switzerland. FAU - Joris, Maria Raquel AU - Joris MR AD - Department of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry, University of Zurich, Zurich, Switzerland. FAU - Karr, Markus AU - Karr M AD - Department of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry, University of Zurich, Zurich, Switzerland. FAU - Studer, Nadja AU - Studer N AD - Department of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry, University of Zurich, Zurich, Switzerland. FAU - Zulauf Logoz, Marina AU - Zulauf Logoz M AD - Department of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry, University of Zurich, Zurich, Switzerland. FAU - Roth, Alexander AU - Roth A AD - Department of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry, University of Zurich, Zurich, Switzerland. FAU - Rossler, Wulf AU - Rossler W AD - The Zurich Program for Sustainable Development of Mental Health Services (ZInEP), University Hospital of Psychiatry Zurich, Zurich, Switzerland. AD - Department of Psychiatry, Psychotherapy and Psychosomatics, Zurich University Hospital of Psychiatry, Zurich, Switzerland. AD - Department of Psychiatry and Psychotherapy, Charite University Medicine, Berlin, Germany. AD - Laboratory of Neuroscience, LIM27, Institute of Psychiatry, University of Sao Paulo, Sao Paulo, Brazil. FAU - Walitza, Susanne AU - Walitza S AD - Department of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry, University of Zurich, Zurich, Switzerland. AD - The Zurich Program for Sustainable Development of Mental Health Services (ZInEP), University Hospital of Psychiatry Zurich, Zurich, Switzerland. AD - Neuroscience Center Zurich, University of Zurich and ETH Zurich, Zurich, Switzerland. AD - Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland. FAU - Franscini, Maurizia AU - Franscini M AD - Department of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry, University of Zurich, Zurich, Switzerland. AD - The Zurich Program for Sustainable Development of Mental Health Services (ZInEP), University Hospital of Psychiatry Zurich, Zurich, Switzerland. LA - eng SI - ClinicalTrials.gov/NCT03829527 PT - Case Reports DEP - 20190606 PL - Switzerland TA - Front Psychiatry JT - Frontiers in psychiatry JID - 101545006 PMC - PMC6562244 OTO - NOTNLM OT - clinical high risk of psychosis OT - eMental health OT - early intervention OT - psychological intervention OT - psychosis OT - youth mental health EDAT- 2019/06/28 06:00 MHDA- 2019/06/28 06:01 PMCR- 2019/06/06 CRDT- 2019/06/28 06:00 PHST- 2019/02/05 00:00 [received] PHST- 2019/05/15 00:00 [accepted] PHST- 2019/06/28 06:00 [entrez] PHST- 2019/06/28 06:00 [pubmed] PHST- 2019/06/28 06:01 [medline] PHST- 2019/06/06 00:00 [pmc-release] AID - 10.3389/fpsyt.2019.00384 [doi] PST - epublish SO - Front Psychiatry. 2019 Jun 6;10:384. doi: 10.3389/fpsyt.2019.00384. eCollection 2019.