PMID- 31244850
OWN - NLM
STAT- MEDLINE
DCOM- 20201022
LR  - 20220105
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 10
DP  - 2019
TI  - Role of Dendritic Cells in Natural Immune Control of HIV-1 Infection.
PG  - 1306
LID - 10.3389/fimmu.2019.01306 [doi]
LID - 1306
AB  - Dendritic cells (DCs) are professional antigen-presenting cells that link innate 
      and adaptive immunity and are critical for the induction of protective immune 
      responses against pathogens. Proportions of these cells are markedly decreased in 
      the blood of untreated HIV-1-infected individuals, suggesting they might be 
      intrinsically involved in HIV-1 pathogenesis. However, despite several decades of 
      active research, the precise role and contribution of these cells to protective 
      or detrimental host responses against HIV-1 are still remarkably unclear. Recent 
      studies have shown that DCs possess a fine-tuned machinery to recognize HIV-1 
      replication products through a variety of innate pathogen sensing mechanisms, 
      which may be instrumental for generating both cellular and humoral protective 
      immune responses in persons who naturally control HIV-1 replication. Yet, 
      dysregulated and abnormal activation of DCs might also contribute to sustained 
      inflammation and immune activation accelerating disease progression during 
      chronic progressive infection. Emerging data also suggest that DCs can influence 
      the induction of potent broadly-neutralizing antibodies, and may, for this 
      reason, have to be considered as important components of future HIV-1 vaccination 
      strategies. Apart from their involvement in antiviral host immunity, at least a 
      subgroup of DCs seem intrinsically susceptible to HIV-1 infection and may serve 
      as a viral target cell population. Indeed recent studies suggest that specific DC 
      subpopulations residing in the genital mucosa are preferentially infected by 
      HIV-1 and play an active role in sexual transmission; therefore, DCs may 
      contribute to viral dissemination and possible persistence of the viral 
      reservoirs through either direct or indirect mechanisms. Here, we analyze the 
      distinct and partially opposing roles of DCs during HIV-1 disease pathogenesis, 
      with a focus on implications of DC biology natural immune control and HIV cure 
      research efforts.
FAU - Martin-Gayo, Enrique
AU  - Martin-Gayo E
AD  - Hospital Universitario de la Princesa, Universidad Autonoma de Madrid, Madrid, 
      Spain.
FAU - Yu, Xu G
AU  - Yu XG
AD  - Ragon Institute of MGH, MIT, and Harvard, Massachusetts General Hospital, Harvard 
      Medical School, Boston, MA, United States.
LA  - eng
GR  - AI135940/NH/NIH HHS/United States
GR  - R33 AI116228/AI/NIAID NIH HHS/United States
GR  - AI117841/NH/NIH HHS/United States
GR  - HL134539/NH/NIH HHS/United States
GR  - AI116228/NH/NIH HHS/United States
GR  - R01 AI078799/AI/NIAID NIH HHS/United States
GR  - AI125109/NH/NIH HHS/United States
GR  - R21 AI140930/AI/NIAID NIH HHS/United States
GR  - AI114235/NH/NIH HHS/United States
GR  - AI078799/NH/NIH HHS/United States
GR  - DA047034/NH/NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20190606
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
SB  - IM
MH  - Animals
MH  - Dendritic Cells/*immunology
MH  - HIV Infections/*immunology
MH  - HIV-1/*immunology
MH  - Humans
MH  - Inflammation/immunology
MH  - Virus Replication/immunology
PMC - PMC6563724
OTO - NOTNLM
OT  - HIV-1 controller
OT  - IFN
OT  - Tfh
OT  - bNAb
OT  - dendritic cell
OT  - vaccine
EDAT- 2019/06/28 06:00
MHDA- 2020/10/23 06:00
PMCR- 2019/01/01
CRDT- 2019/06/28 06:00
PHST- 2019/03/21 00:00 [received]
PHST- 2019/05/22 00:00 [accepted]
PHST- 2019/06/28 06:00 [entrez]
PHST- 2019/06/28 06:00 [pubmed]
PHST- 2020/10/23 06:00 [medline]
PHST- 2019/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2019.01306 [doi]
PST - epublish
SO  - Front Immunol. 2019 Jun 6;10:1306. doi: 10.3389/fimmu.2019.01306. eCollection 
      2019.