PMID- 31246315
OWN - NLM
STAT- MEDLINE
DCOM- 20200416
LR  - 20200416
IS  - 1468-3083 (Electronic)
IS  - 0926-9959 (Linking)
VI  - 33
IP  - 11
DP  - 2019 Nov
TI  - Sex matters: men with melanoma have a worse prognosis than women.
PG  - 2062-2067
LID - 10.1111/jdv.15760 [doi]
AB  - BACKGROUND: In Europe, one of the highest melanoma incidences is found in the 
      Netherlands. Like in several other European countries, females are more prone to 
      develop melanoma as compared to males, although survival is worse for men. 
      OBJECTIVE: To identify clinicopathological gender-related differences that may 
      lead to gender-specific preventive measures. METHODS: Data from the Dutch 
      Nationwide Network and Registry of Histopathology and Cytopathology (PALGA) were 
      retrieved from patients with primary, cutaneous melanoma in the Netherlands 
      between 2000 and 2014. Patients initially presenting as stage I, II and III 
      without clinically detectable nodal disease were included. Follow-up data were 
      retrieved from the Netherlands Cancer Registry. Gender-related differences were 
      assessed, and to compare relative survival between males and females, 
      multivariable relative excess risks (RER) were calculated. RESULTS: A total of 
      54.645 patients were included (43.7% men). In 2000, 41.7% of the cohort was male, 
      as compared to 47.3% in 2014 (P < 0.001). Likewise, in 2000, 51.5% of the 
      deceased cohort was male compared to 60.1% in 2014 (P < 0.001). Men had 
      significantly thicker melanomas at the time of diagnosis [median Breslow 
      thickness 1.00 mm (interquartile range (IQR): 0.60-2.00) vs. 0.82 mm (IQR: 
      0.50-1.50) for females] and were significantly older at the time of diagnosis, 
      more often had ulcerated melanomas and melanomas localized on the trunk or head 
      and neck. Over time, survival for females improved while that of men decreased 
      (P < 0.001). RER for dying was 1.37 (95% CI: 1.31-1.45) for men in multivariable 
      analysis. CONCLUSION: There are evident clinicopathological differences between 
      male and female melanoma patients. After multivariable correction for all these 
      differences, relative survival remains worse for men. Clinicians as well as 
      persons at risk for melanoma should be aware of these differences, as awareness 
      and prevention might lead to a lower incidence and mortality of melanoma. This 
      indicates the need of prevention campaigns integrating and targeting specific 
      risk profiles.
CI  - (c) 2019 European Academy of Dermatology and Venereology.
FAU - El Sharouni, M A
AU  - El Sharouni MA
AD  - Department of Dermatology, University Medical Center Utrecht, Utrecht University, 
      Utrecht, The Netherlands.
FAU - Witkamp, A J
AU  - Witkamp AJ
AD  - Department of Surgery, University Medical Center Utrecht, Utrecht University, 
      Utrecht, The Netherlands.
FAU - Sigurdsson, V
AU  - Sigurdsson V
AD  - Department of Dermatology, University Medical Center Utrecht, Utrecht University, 
      Utrecht, The Netherlands.
FAU - van Diest, P J
AU  - van Diest PJ
AD  - Department of Pathology, University Medical Center Utrecht, Utrecht University, 
      Utrecht, The Netherlands.
FAU - Louwman, M W J
AU  - Louwman MWJ
AD  - Netherlands Comprehensive Cancer Organization (IKNL), Utrecht, The Netherlands.
FAU - Kukutsch, N A
AU  - Kukutsch NA
AUID- ORCID: 0000-0001-7262-0004
AD  - Department of Dermatology, Leiden University Medical Center, Leiden, The 
      Netherlands.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20190716
PL  - England
TA  - J Eur Acad Dermatol Venereol
JT  - Journal of the European Academy of Dermatology and Venereology : JEADV
JID - 9216037
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Cohort Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Melanoma/*diagnosis/*epidemiology
MH  - Middle Aged
MH  - Netherlands/epidemiology
MH  - Prognosis
MH  - Retrospective Studies
MH  - Sex Distribution
MH  - Sex Factors
MH  - Skin Neoplasms/*diagnosis/*epidemiology
MH  - Young Adult
EDAT- 2019/06/28 06:00
MHDA- 2020/04/17 06:00
CRDT- 2019/06/28 06:00
PHST- 2019/02/17 00:00 [received]
PHST- 2019/06/06 00:00 [accepted]
PHST- 2019/06/28 06:00 [pubmed]
PHST- 2020/04/17 06:00 [medline]
PHST- 2019/06/28 06:00 [entrez]
AID - 10.1111/jdv.15760 [doi]
PST - ppublish
SO  - J Eur Acad Dermatol Venereol. 2019 Nov;33(11):2062-2067. doi: 10.1111/jdv.15760. 
      Epub 2019 Jul 16.