PMID- 31246375
OWN - NLM
STAT- MEDLINE
DCOM- 20200527
LR  - 20200901
IS  - 2042-6984 (Electronic)
IS  - 2042-6976 (Print)
IS  - 2042-6976 (Linking)
VI  - 9
IP  - 9
DP  - 2019 Sep
TI  - Central compartment involvement in aspirin-exacerbated respiratory disease: the 
      role of allergy and previous sinus surgery.
PG  - 1017-1022
LID - 10.1002/alr.22367 [doi]
AB  - BACKGROUND: Evidence for a relationship between allergy and chronic 
      rhinosinusitus with nasal polyps (CRSwNP) is equivocal. Central compartment (CC) 
      atopic disease is a nasal inflammatory condition related to inhalant allergy. CC 
      involvement is common in aspirin-exacerbated respiratory disease (AERD), a subset 
      of CRSwNP, and we hypothesize it is related to allergic status. METHODS: This 
      study was a retrospective analysis of a single-institution database for the 
      January 2016 to February 2019 time period. Data regarding endoscopic CC findings, 
      clinical allergy history, and results of allergy testing were collected. 
      Statistical analysis was performed, with significance set at p < 0.05. RESULTS: 
      Seventy-two AERD patients met the inclusion criteria. Fifty-nine patients had CC 
      involvement (53 bilateral, 6 unilateral). For patients with documented allergy 
      status, 100% of patients with endoscopic CC disease had clinical allergic 
      rhinitis (AR), and 45 of 48 (93.8%) had positive allergy testing. Thirteen 
      patients had no CC involvement (4 with clinical AR; 3 of 7 with positive allergy 
      testing). CC endoscopic findings in AERD were significantly associated with 
      clinical allergy (p < 0.0001, phi = 0.771). Overall, patients with CC involvement 
      averaged 3.8 surgeries vs 3.2 for those without CC involvement (p = not 
      statistically significant). However, patients with septal involvement averaged 
      4.2 surgeries vs 2.0 for those without septal involvement (p = 0.004). As the 
      number of sinus surgeries increases, middle turbinate (MT) resection (r = 0.300, 
      p = 0.022) and septal involvement (r = 0.372, p = 0.004) significantly increase. 
      All patients with MT resection had septal disease, whereas none without CC 
      disease had MT resection. CONCLUSION: Most AERD patients exhibit AR, and this 
      correlates with CC disease. As the number of surgeries increases, MT resection 
      may predispose to polyposis of the septum.
CI  - (c) 2019 ARS-AAOA, LLC.
FAU - DelGaudio, John M
AU  - DelGaudio JM
AD  - Department of Otolaryngology-Head and Neck Surgery, Emory University, Atlanta, 
      GA.
FAU - Levy, Joshua M
AU  - Levy JM
AUID- ORCID: 0000-0001-5907-3421
AD  - Department of Otolaryngology-Head and Neck Surgery, Emory University, Atlanta, 
      GA.
FAU - Wise, Sarah K
AU  - Wise SK
AD  - Department of Otolaryngology-Head and Neck Surgery, Emory University, Atlanta, 
      GA.
LA  - eng
GR  - KL2 TR002381/TR/NCATS NIH HHS/United States
GR  - UL1 TR002378/TR/NCATS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20190627
PL  - United States
TA  - Int Forum Allergy Rhinol
JT  - International forum of allergy & rhinology
JID - 101550261
RN  - 0 (Allergens)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Allergens/immunology
MH  - Asthma, Aspirin-Induced/*epidemiology/surgery
MH  - Chronic Disease
MH  - Endoscopy
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nasal Polyps/*epidemiology/surgery
MH  - Paranasal Sinuses/*surgery
MH  - Retrospective Studies
MH  - Rhinitis, Allergic/*epidemiology/surgery
MH  - *Rhinoplasty
MH  - Sinusitis/*epidemiology/surgery
MH  - Young Adult
PMC - PMC6748623
MID - NIHMS1050319
OTO - NOTNLM
OT  - allergic rhinitis
OT  - allergy
OT  - aspirin-exacerbated respiratory disease
OT  - chronic rhinosinusitis
OT  - chronic sinusitis
OT  - endoscopic sinus surgery
OT  - nasal polyp
COIS- Potential conflict of interest: J.M.D.: Spirox, grant support; Medtronic, 
      consultant. S.K.W: OptiNose, scientific advisory board; SinopSys Surgical, 
      scientific advisory board; Stryker, consultant; and NeurENT, consultant.
EDAT- 2019/06/28 06:00
MHDA- 2020/05/28 06:00
PMCR- 2020/09/01
CRDT- 2019/06/28 06:00
PHST- 2019/03/19 00:00 [received]
PHST- 2019/05/15 00:00 [revised]
PHST- 2019/05/27 00:00 [accepted]
PHST- 2019/06/28 06:00 [pubmed]
PHST- 2020/05/28 06:00 [medline]
PHST- 2019/06/28 06:00 [entrez]
PHST- 2020/09/01 00:00 [pmc-release]
AID - 10.1002/alr.22367 [doi]
PST - ppublish
SO  - Int Forum Allergy Rhinol. 2019 Sep;9(9):1017-1022. doi: 10.1002/alr.22367. Epub 
      2019 Jun 27.