PMID- 31247042
OWN - NLM
STAT- MEDLINE
DCOM- 20200224
LR  - 20200309
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 14
IP  - 6
DP  - 2019
TI  - Quality of life and outcomes in heart failure patients with ejection fractions in 
      different ranges.
PG  - e0218983
LID - 10.1371/journal.pone.0218983 [doi]
LID - e0218983
AB  - AIMS: Guidelines divide patients with heart failure (HF) into 3 distinct groups 
      based on left ventricular ejection fraction (LVEF) We used the Minnesota Living 
      with Heart Failure Questionnaire (MLHFQ) to quantify the health-related quality 
      of life in patients with HF. METHODS: Patients were stratified into three 
      cohorts: preserved LVEF (>50%), mid-range LVEF (40-49%) and reduced LVEF (<40%). 
      The MLHFQ scores were evaluated using one-way ANOVA, and differences were 
      observed among the groups. The association of New York Heart Association (NYHA) 
      class with the physical scores was analyzed by Spearman's correlation analysis. 
      The predictive utility of the total MLHFQ scores was assessed with Kaplan-Meier 
      curves for death and HF-related hospitalization. The Cox proportional hazards 
      model was used to identify the risk factors for prognosis. Internal reliability 
      was assessed with Cronbach's alpha. RESULTS: There were significant differences in 
      the total MLHFQ scores and the MLHFQ subscale scores among the three groups 
      (p<0.05). MLHFQ domains demonstrated high internal consistency among the three 
      groups (Cronbach's alpha = 0.92, 0.96 and 0.93). The MLHFQ physical subscale scores 
      were significantly associated with NYHA class in HFrEF (r = 0.59, p<0.001) and 
      HFmrEF patients (r = 0.537, p<0.001). The survival analysis indicated that there 
      was a significant difference among the three groups regarding high MLHFQ scores 
      (p = 0.038). In the groups with low MLHFQ scores, the HFmrEF group exhibited 
      significantly increased rates of death and HF-related hospitalization compared 
      with the HFpEF group (p = 0.035). CONCLUSIONS: The features and clinical outcomes 
      varied among heart failure patients with different EF values. The MLHFQ appears 
      to be a valid and reliable measurement of health status and offers excellent 
      prognostic ability.
FAU - Chen, Xin
AU  - Chen X
AD  - Department of Cardiology, The First Affiliated Hospital, China Medical 
      University, Shenyang, China.
AD  - Department of Cardiology, Fuling Central Hospital, Chongqing, China.
FAU - Xin, Yanguo
AU  - Xin Y
AD  - Department of Cardiology, West China Hospital of Sichuan University, Chengdu, 
      China.
FAU - Hu, Wenyu
AU  - Hu W
AD  - Department of Cardiology, The First Affiliated Hospital, China Medical 
      University, Shenyang, China.
FAU - Zhao, Yinan
AU  - Zhao Y
AD  - Department of Cardiology, The First Affiliated Hospital, China Medical 
      University, Shenyang, China.
FAU - Zhang, Zixin
AU  - Zhang Z
AD  - Department of Cardiology, The First Affiliated Hospital, China Medical 
      University, Shenyang, China.
FAU - Zhou, Yinpin
AU  - Zhou Y
AUID- ORCID: 0000-0001-9797-0633
AD  - Department of Cardiology, Fuling Central Hospital, Chongqing, China.
LA  - eng
PT  - Journal Article
DEP - 20190627
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - China/epidemiology
MH  - Female
MH  - Health Status
MH  - Heart Failure/classification/mortality/*physiopathology
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Proportional Hazards Models
MH  - *Quality of Life
MH  - Risk Factors
MH  - Surveys and Questionnaires
MH  - Ventricular Dysfunction, Left/classification/*physiopathology
PMC - PMC6597164
COIS- The authors have declared that no competing interests exist.
EDAT- 2019/06/28 06:00
MHDA- 2020/02/25 06:00
PMCR- 2019/06/27
CRDT- 2019/06/28 06:00
PHST- 2018/09/08 00:00 [received]
PHST- 2019/06/13 00:00 [accepted]
PHST- 2019/06/28 06:00 [entrez]
PHST- 2019/06/28 06:00 [pubmed]
PHST- 2020/02/25 06:00 [medline]
PHST- 2019/06/27 00:00 [pmc-release]
AID - PONE-D-18-25755 [pii]
AID - 10.1371/journal.pone.0218983 [doi]
PST - epublish
SO  - PLoS One. 2019 Jun 27;14(6):e0218983. doi: 10.1371/journal.pone.0218983. 
      eCollection 2019.