PMID- 31249603 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220409 IS - 1710-1484 (Print) IS - 1710-1492 (Electronic) IS - 1710-1484 (Linking) VI - 15 DP - 2019 TI - Inflammatory patterns of antrochoanal polyps in the pediatric age group. PG - 39 LID - 10.1186/s13223-019-0352-3 [doi] LID - 39 AB - BACKGROUND: The pathogenesis and etiology of antrochoanal polyps (ACPs) remains obscure. This study aimed to characterize the inflammatory profiles and investigate the effect of atopy on the pathogenesis of pediatric ACPs. METHODS: Thirty-three ACP patients and ten control subjects were enrolled from January to December 2017. The severity of individual nasal symptoms was scored on a visual analogue scale (VAS). The serum total immunoglobulin E (IgE) and cytokines level was measured by multiplexed luminex assay. RESULTS: There was no significant difference in VAS scores and counts of inflammatory cells between atopic and nonatopic ACP. No difference in IFNgamma, IL-4, IL-5, IL-13, IL-17A and IL-25 was found between control and whole ACP, nonatopic and atopic ACP. Significantly increased levels of IL-6 and IL-10 were found in ACP compared with control. For neutrophil chemotactic factor, significant increases of IL-8 and GRO were observed in ACP, but for eosinophil chemotactic factor, no difference was found in RANTES and GM-CSF. IL-6 level was positively correlated with IL-8, MCP1, and GRO level, and IL-10 level was positively correlated with IL-4 and IL-13 in ACP subjects. CONCLUSION: Nasal obstruction was the most common symptom in ACPs in children. Allergic condition may have a poor role in the pathogenesis of ACPs. IL-6 plays a crucial role in the pathogenesis of neutrophilic inflammation in patients with ACPs and may provide a new treatment strategy for ACPs in children. Treg cell associated cytokine IL-10 was involved in the inflammatory pathophysiological process of ACPs and played a certain regulatory role. FAU - Zheng, Huiwen AU - Zheng H AD - 1Beijing Key Laboratory for Pediatric Diseases of Otolaryngology, Head and Neck Surgery, MOE Key Laboratory of Major Diseases in Children, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. ISNI: 0000 0004 0369 153X. GRID: grid.24696.3f FAU - Tang, Lixing AU - Tang L AD - 2Head and Neck Surgery, Beijing Children's Hospital, Capital Medical University, Beijing, China. ISNI: 0000 0004 0369 153X. GRID: grid.24696.3f FAU - Song, Beibei AU - Song B AD - 2Head and Neck Surgery, Beijing Children's Hospital, Capital Medical University, Beijing, China. ISNI: 0000 0004 0369 153X. GRID: grid.24696.3f FAU - Yang, Xiaojian AU - Yang X AD - 2Head and Neck Surgery, Beijing Children's Hospital, Capital Medical University, Beijing, China. ISNI: 0000 0004 0369 153X. GRID: grid.24696.3f FAU - Chu, Ping AU - Chu P AD - 1Beijing Key Laboratory for Pediatric Diseases of Otolaryngology, Head and Neck Surgery, MOE Key Laboratory of Major Diseases in Children, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. ISNI: 0000 0004 0369 153X. GRID: grid.24696.3f FAU - Han, Shujing AU - Han S AD - 1Beijing Key Laboratory for Pediatric Diseases of Otolaryngology, Head and Neck Surgery, MOE Key Laboratory of Major Diseases in Children, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. ISNI: 0000 0004 0369 153X. GRID: grid.24696.3f FAU - Wang, Pengpeng AU - Wang P AD - 2Head and Neck Surgery, Beijing Children's Hospital, Capital Medical University, Beijing, China. ISNI: 0000 0004 0369 153X. GRID: grid.24696.3f FAU - Lu, Jie AU - Lu J AD - 1Beijing Key Laboratory for Pediatric Diseases of Otolaryngology, Head and Neck Surgery, MOE Key Laboratory of Major Diseases in Children, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. ISNI: 0000 0004 0369 153X. GRID: grid.24696.3f FAU - Ge, Wentong AU - Ge W AD - 1Beijing Key Laboratory for Pediatric Diseases of Otolaryngology, Head and Neck Surgery, MOE Key Laboratory of Major Diseases in Children, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. ISNI: 0000 0004 0369 153X. GRID: grid.24696.3f AD - 2Head and Neck Surgery, Beijing Children's Hospital, Capital Medical University, Beijing, China. ISNI: 0000 0004 0369 153X. GRID: grid.24696.3f FAU - Ni, Xin AU - Ni X AD - 1Beijing Key Laboratory for Pediatric Diseases of Otolaryngology, Head and Neck Surgery, MOE Key Laboratory of Major Diseases in Children, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. ISNI: 0000 0004 0369 153X. GRID: grid.24696.3f AD - 2Head and Neck Surgery, Beijing Children's Hospital, Capital Medical University, Beijing, China. ISNI: 0000 0004 0369 153X. GRID: grid.24696.3f LA - eng PT - Journal Article DEP - 20190620 PL - England TA - Allergy Asthma Clin Immunol JT - Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology JID - 101244313 PMC - PMC6585040 OTO - NOTNLM OT - Antrochoanal polyps OT - Atopy OT - Cytokine COIS- Competing interestsThe authors declare that they have no competing interests. EDAT- 2019/06/30 06:00 MHDA- 2019/06/30 06:01 PMCR- 2019/06/20 CRDT- 2019/06/29 06:00 PHST- 2018/11/28 00:00 [received] PHST- 2019/06/13 00:00 [accepted] PHST- 2019/06/29 06:00 [entrez] PHST- 2019/06/30 06:00 [pubmed] PHST- 2019/06/30 06:01 [medline] PHST- 2019/06/20 00:00 [pmc-release] AID - 352 [pii] AID - 10.1186/s13223-019-0352-3 [doi] PST - epublish SO - Allergy Asthma Clin Immunol. 2019 Jun 20;15:39. doi: 10.1186/s13223-019-0352-3. eCollection 2019.