PMID- 31249940
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2512-9465 (Electronic)
IS  - 2567-3459 (Print)
IS  - 2512-9465 (Linking)
VI  - 2
IP  - 2
DP  - 2018 Apr
TI  - Risk of Thrombosis in Patients Presenting with Myocardial Infarction with 
      Nonobstructive Coronary Arteries (MINOCA).
PG  - e167-e172
LID - 10.1055/s-0038-1645875 [doi]
AB  - Patients presenting with myocardial infarction (MI) in the absence of obstructive 
      coronary artery disease (CAD) is termed MI with nonobstructive coronary arteries 
      (MINOCA). The underlying pathophysiology of MINOCA is multifactorial and in situ 
      formation and subsequent spontaneous lysis of a coronary thrombus is often 
      hypothesized as one of the mechanisms. The objective of this study is to 
      determine whether MINOCA patients had a greater prothrombotic tendency in 
      comparison to MI patients with obstructive CAD (MICAD). Prospectively, blood 
      samples of 25 consecutive MINOCA patients (58 (interquartile range [IQR]: 48, 75) 
      years, 48% women) and 25 age-/gender-matched MICAD patients (58 (IQR: 50, 66) 
      years, 48% women) were obtained at 1 month after the initial presentation and 
      overall thrombin generation potential and congenital/acquired thrombophilia 
      states were assessed. As regard to results, overall thrombin generation 
      parameters were similar ( p  > 0.05) between the MINOCA and MICAD groups, 
      highlighting similar endogenous thrombin potential (1,590 nM/min; IQR: 1,380, 
      2,000 vs. 1,750 nM/min; IQR: 1,500, 2,040, respectively). There were no 
      significant differences between MINOCA and MICAD, respectively, in respect to the 
      numbers of patients with congenital thrombophilia states including factor V 
      Leiden (0 vs. 4%) and prothrombin gene mutation (8 vs. 4%), decreased 
      antithrombin (8 vs. 0%), protein C (0 vs. 0%), and protein S (4 vs. 0%). None of 
      the patients demonstrated presence of lupus anticoagulant and anticardiolipin 
      antibodies. Although MINOCA patients revealed thrombotic characteristics that are 
      similar to those with MICAD, the results from this study are inconclusive and a 
      larger study with healthy control subjects is required to assess the risk of 
      thrombosis in MINOCA.
FAU - Pasupathy, Sivabaskari
AU  - Pasupathy S
AD  - Discipline of Medicine, University of Adelaide, Adelaide, South Australia, 
      Australia.
AD  - Central Adelaide Local Health Network, Adelaide, South Australia, Australia.
FAU - Rodgers, Susan
AU  - Rodgers S
AD  - Division of Hematology, SA Pathology, Adelaide, South Australia, Australia.
AD  - School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, 
      South Australia, Australia.
FAU - Tavella, Rosanna
AU  - Tavella R
AD  - Discipline of Medicine, University of Adelaide, Adelaide, South Australia, 
      Australia.
AD  - Central Adelaide Local Health Network, Adelaide, South Australia, Australia.
FAU - McRae, Simon
AU  - McRae S
AD  - Central Adelaide Local Health Network, Adelaide, South Australia, Australia.
AD  - Division of Hematology, SA Pathology, Adelaide, South Australia, Australia.
AD  - School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, 
      South Australia, Australia.
FAU - Beltrame, John F
AU  - Beltrame JF
AD  - Discipline of Medicine, University of Adelaide, Adelaide, South Australia, 
      Australia.
AD  - Central Adelaide Local Health Network, Adelaide, South Australia, Australia.
LA  - eng
PT  - Journal Article
DEP - 20180503
PL  - Germany
TA  - TH Open
JT  - TH open : companion journal to thrombosis and haemostasis
JID - 101715740
PMC - PMC6524870
OTO - NOTNLM
OT  - MINOCA
OT  - coagulation factors
OT  - thrombophilia
OT  - thrombosis
COIS- Conflict of Interest None declared.
EDAT- 2019/06/30 06:00
MHDA- 2019/06/30 06:01
PMCR- 2018/05/03
CRDT- 2019/06/29 06:00
PHST- 2018/01/02 00:00 [received]
PHST- 2018/03/19 00:00 [accepted]
PHST- 2019/06/29 06:00 [entrez]
PHST- 2019/06/30 06:00 [pubmed]
PHST- 2019/06/30 06:01 [medline]
PHST- 2018/05/03 00:00 [pmc-release]
AID - 180002 [pii]
AID - 10.1055/s-0038-1645875 [doi]
PST - epublish
SO  - TH Open. 2018 May 3;2(2):e167-e172. doi: 10.1055/s-0038-1645875. eCollection 2018 
      Apr.