PMID- 31250183
OWN - NLM
STAT- MEDLINE
DCOM- 20191113
LR  - 20230918
IS  - 1433-7339 (Electronic)
IS  - 0941-4355 (Linking)
VI  - 27
IP  - 10
DP  - 2019 Oct
TI  - Psychostimulants for cancer-related cognitive impairment in adult cancer 
      survivors: a systematic review and meta-analysis.
PG  - 3717-3727
LID - 10.1007/s00520-019-04907-w [doi]
AB  - BACKGROUND: Cognitive impairment is recognized as a common symptom experienced by 
      cancer survivors which impacts on quality of life (QoL) and day-to-day 
      activities. One of the treatment options is the use of psychostimulants but the 
      evidence supporting its use remains unclear. OBJECTIVES: To identify the level of 
      evidence of psychostimulants' effect on the management of cognitive impairment in 
      adult cancer survivors. METHODS: Electronic databases (MEDLINE, EMBASE, CENTRAL, 
      CINAHL) and reference lists of relevant reviews were searched from inception to 
      December 2017, with no language restrictions applied. Randomized controlled 
      trials (RCTs), evaluating the effect of psychostimulants on cognitive impairment 
      among cancer patients with no primary or secondary brain tumor or brain 
      radiation, were included. The primary outcome was cognitive function changes, 
      whereas secondary outcomes were adverse events (AEs) and QoL. RESULTS: Six RCTs 
      were included: three studies investigating methylphenidate and three modafinil, 
      with a total of 244 and 146 patients, respectively. Due to important differences 
      in methodologies between studies, a meta-analysis was assumed inappropriate for 
      the primary outcome. A narrative synthesis was performed. One study using 
      methylphenidate and two using modafinil demonstrated improvements in some 
      cognitive functions as measured by objective cognitive assessment tests. 
      Psychostimulants did not improve QoL and were not associated with more AEs. 
      CONCLUSION: To date, limited evidence is available to estimate the usefulness (or 
      lack) of psychostimulants on cognitive function in this population.
FAU - Miladi, Nadia
AU  - Miladi N
AUID- ORCID: 0000-0002-0153-9302
AD  - Oncology Division, CHU de Quebec-Laval University Research Center, Quebec City, 
      QC, Canada.
FAU - Dossa, Richi
AU  - Dossa R
AD  - Oncology Division, CHU de Quebec-Laval University Research Center, Quebec City, 
      QC, Canada.
FAU - Dogba, Maman Joyce
AU  - Dogba MJ
AD  - Oncology Division, CHU de Quebec-Laval University Research Center, Quebec City, 
      QC, Canada.
FAU - Cleophat-Jolicoeur, Marie Immacula Fabienne
AU  - Cleophat-Jolicoeur MIF
AD  - Oncology Division, CHU de Quebec-Laval University Research Center, Quebec City, 
      QC, Canada.
FAU - Gagnon, Bruno
AU  - Gagnon B
AD  - Oncology Division, CHU de Quebec-Laval University Research Center, Quebec City, 
      QC, Canada. Gagnon.Bruno@crchudequebec.ulaval.ca.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20190628
PL  - Germany
TA  - Support Care Cancer
JT  - Supportive care in cancer : official journal of the Multinational Association of 
      Supportive Care in Cancer
JID - 9302957
RN  - 0 (Central Nervous System Stimulants)
RN  - 207ZZ9QZ49 (Methylphenidate)
RN  - R3UK8X3U3D (Modafinil)
SB  - IM
MH  - Adult
MH  - Cancer Survivors/*psychology
MH  - Central Nervous System Stimulants/*therapeutic use
MH  - Cognition/drug effects
MH  - Cognitive Dysfunction/*drug therapy
MH  - Humans
MH  - Methylphenidate/therapeutic use
MH  - Modafinil/therapeutic use
MH  - Neoplasms/therapy
MH  - Quality of Life/*psychology
MH  - Randomized Controlled Trials as Topic
OTO - NOTNLM
OT  - Cancer
OT  - Cognitive impairment
OT  - Psychostimulants
OT  - Survivorship
EDAT- 2019/06/30 06:00
MHDA- 2019/11/14 06:00
CRDT- 2019/06/29 06:00
PHST- 2018/10/15 00:00 [received]
PHST- 2019/05/31 00:00 [accepted]
PHST- 2019/06/30 06:00 [pubmed]
PHST- 2019/11/14 06:00 [medline]
PHST- 2019/06/29 06:00 [entrez]
AID - 10.1007/s00520-019-04907-w [pii]
AID - 10.1007/s00520-019-04907-w [doi]
PST - ppublish
SO  - Support Care Cancer. 2019 Oct;27(10):3717-3727. doi: 10.1007/s00520-019-04907-w. 
      Epub 2019 Jun 28.