PMID- 31250339
OWN - NLM
STAT- MEDLINE
DCOM- 20200219
LR  - 20200225
IS  - 1573-2584 (Electronic)
IS  - 0301-1623 (Linking)
VI  - 51
IP  - 8
DP  - 2019 Aug
TI  - Association of urinary monocyte chemoattractant protein-1 (MCP-1) and kidney 
      injury molecule-1 (KIM-1) with risk factors of diabetic kidney disease in type 2 
      diabetes patients.
PG  - 1379-1386
LID - 10.1007/s11255-019-02201-6 [doi]
AB  - PURPOSE: Urinary kidney injury molecule-1 and monocyte chemoattractant protein-1 
      are significance factors in the diagnosis and intervention of diabetic kidney 
      diseases. This study determined levels of these proteins in diabetic patients 
      with varying degrees of kidney disease and assessed their relationship with risk 
      factors associated with diabetic kidney diseases. METHODS: A total of 185 
      patients with type 2 diabetes were divided into three groups [low risk (n = 47), 
      moderate risk (n = 63), and high risk (n = 75)] based on the severity of diabetic 
      kidney disease according to kidney disease: improving global outcomes guidelines. 
      Both urinary kidney injury molecule-1 and monocyte chemoattractant protein-1 
      levels were measured by enzyme-linked immunosorbent assay. Student;s t test, 
      analysis of variance, and Spearman's correlation were used for statistical 
      analysis. RESULTS: The kidney injury molecule-1-to-creatinine ratio (P = 0.035) 
      and monocyte chemoattractant protein-1-to-creatinine ratio (P < 0.001) increased 
      significantly with the increase in kidney disease severity and varied according 
      to different albuminuria statuses and estimated glomerular-filtration rates. The 
      monocyte chemoattractant protein-1-to-creatinine ratio showed a significant 
      correlation with hemoglobin A1c (P = 0.002) and inflammatory marker levels 
      (interleukin-6, P = 0.005; tumor necrosis factor-alpha, P < 0.001). CONCLUSION: 
      Urinary levels of both kidney injury molecule-1 and monocyte chemoattractant 
      protein-1 represent distinguishing markers for the evaluation of diabetic kidney 
      disease progression according to the associated degrees of albuminuria or/and the 
      estimated glomerular-filtration rate. In addition, correlations between urinary 
      monocyte chemoattractant protein-1 and glycemic and inflammatory marker levels 
      revealed the role of hyperglycemia and chronic inflammation in the pathogenesis 
      of diabetic kidney disease.
FAU - Siddiqui, Khalid
AU  - Siddiqui K
AUID- ORCID: 0000-0003-4860-1262
AD  - Strategic Center for Diabetes Research, College of Medicine, King Saud 
      University, Riyadh, Saudi Arabia. ksiddiqui@ksu.edu.sa.
FAU - Joy, Salini Scaria
AU  - Joy SS
AD  - Strategic Center for Diabetes Research, College of Medicine, King Saud 
      University, Riyadh, Saudi Arabia.
FAU - Al-Rubeaan, Khalid
AU  - Al-Rubeaan K
AD  - University Diabetes Center, King Abdulaziz University Hospital, King Saud 
      University, Riyadh, Saudi Arabia.
LA  - eng
PT  - Journal Article
DEP - 20190619
PL  - Netherlands
TA  - Int Urol Nephrol
JT  - International urology and nephrology
JID - 0262521
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (HAVCR1 protein, human)
RN  - 0 (Hepatitis A Virus Cellular Receptor 1)
SB  - IM
MH  - Chemokine CCL2/*urine
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*urine
MH  - Diabetic Nephropathies/*urine
MH  - Female
MH  - Hepatitis A Virus Cellular Receptor 1/*metabolism
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Risk Factors
OTO - NOTNLM
OT  - Chronic inflammation
OT  - Diabetic kidney disease
OT  - Hyperglycemia
OT  - Kidney injury molecule-1
OT  - Monocyte chemoattractant protein-1
OT  - Type 2 diabetes
EDAT- 2019/06/30 06:00
MHDA- 2020/02/20 06:00
CRDT- 2019/06/29 06:00
PHST- 2019/01/20 00:00 [received]
PHST- 2019/06/10 00:00 [accepted]
PHST- 2019/06/30 06:00 [pubmed]
PHST- 2020/02/20 06:00 [medline]
PHST- 2019/06/29 06:00 [entrez]
AID - 10.1007/s11255-019-02201-6 [pii]
AID - 10.1007/s11255-019-02201-6 [doi]
PST - ppublish
SO  - Int Urol Nephrol. 2019 Aug;51(8):1379-1386. doi: 10.1007/s11255-019-02201-6. Epub 
      2019 Jun 19.