PMID- 3125068
OWN - NLM
STAT- MEDLINE
DCOM- 19880329
LR  - 20190707
IS  - 0015-0282 (Print)
IS  - 0015-0282 (Linking)
VI  - 49
IP  - 3
DP  - 1988 Mar
TI  - Prevention of follicular maturation in endometriosis by subcutaneous infusion of 
      luteinizing hormone-releasing hormone agonist started in the luteal phase.
PG  - 410-7
AB  - Six endometriosis patients were treated with continuous subcutaneous (SC) 
      infusion of a luteinizing hormone-releasing hormone (LH-RH) agonist using an 
      external osmotic minipump system. Serum estradiol (E2) was suppressed into the 
      menopausal range within 1 to 2 weeks of treatment started between days 9 and 12 
      after ovulation. The down-regulation of the pituitary-ovarian axis was maintained 
      for the 24 weeks of treatment. Endometriosis symptoms were relieved during the 
      treatment. At control laparoscopy, implants had regressed markedly and some 
      adhesions had softened, accounting for a significant 58.3% reduction in the mean 
      total American Fertility Society score. Ovulation returned within 14 to 38 days. 
      Four infertile women became pregnant within 2 to 5 months after cessation of 
      treatment. Frequent side effects were hot flushes, and decreased vaginal 
      secretion and libido. There were no significant changes in laboratory blood 
      tests, including cholesterol. The urinary calcium/creatinine ratio increased 
      during the treatment. Thus, starting the treatment in the luteal phase prevented 
      initial follicular stimulation. A better efficacy of treatment would be achieved 
      by the release of an LH-RH agonist at a constant daily rate.
FAU - Lemay, A
AU  - Lemay A
AD  - Centre de Recherche, Hopital St-Francois d'Assise, Universite Laval, Quebec, 
      Canada.
FAU - Sandow, J
AU  - Sandow J
FAU - Bureau, M
AU  - Bureau M
FAU - Maheux, R
AU  - Maheux R
FAU - Fontaine, J Y
AU  - Fontaine JY
FAU - Merat, P
AU  - Merat P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Fertil Steril
JT  - Fertility and sterility
JID - 0372772
RN  - 9002-67-9 (Luteinizing Hormone)
RN  - 9002-68-0 (Follicle Stimulating Hormone)
RN  - PXW8U3YXDV (Buserelin)
SB  - IM
MH  - Adult
MH  - Buserelin/*administration & dosage/adverse effects
MH  - Endometriosis/blood/*drug therapy
MH  - Female
MH  - Follicle Stimulating Hormone/blood
MH  - Humans
MH  - Luteal Phase
MH  - Luteinizing Hormone/blood
MH  - Ovarian Follicle/drug effects/physiology
EDAT- 1988/03/01 00:00
MHDA- 1988/03/01 00:01
CRDT- 1988/03/01 00:00
PHST- 1988/03/01 00:00 [pubmed]
PHST- 1988/03/01 00:01 [medline]
PHST- 1988/03/01 00:00 [entrez]
AID - S0015-0282(16)59764-7 [pii]
AID - 10.1016/s0015-0282(16)59764-7 [doi]
PST - ppublish
SO  - Fertil Steril. 1988 Mar;49(3):410-7. doi: 10.1016/s0015-0282(16)59764-7.