PMID- 31252159
OWN - NLM
STAT- MEDLINE
DCOM- 20200911
LR  - 20200911
IS  - 1873-6815 (Electronic)
IS  - 0531-5565 (Linking)
VI  - 124
DP  - 2019 Sep
TI  - Peak oxygen uptake, six-minute walk distance, six-meter walk speed, and pulse 
      pressure as predictors of seven year all-cause and cardiovascular mortality in 
      community-living older adults.
PG  - 110645
LID - S0531-5565(18)30787-3 [pii]
LID - 10.1016/j.exger.2019.110645 [doi]
AB  - Cardiorespiratory fitness and physical performance measures predict mortality. It 
      is uncertain whether pulse pressure (PP), a measure that is routinely available 
      in healthcare settings, may also predict mortality with a comparable degree of 
      accuracy. In a study consisting of older adults (709 men and 467 women) living in 
      the community, we examined the relationship between PP, peak oxygen uptake (VO2 
      peak), 6-minute walk distance (6MWD) and 6-meter walking speed (6MWS) and seven 
      year all-cause and cardiovascular mortality. Receiver operator characteristic 
      (ROC) curve was used to compare predictive performance. In the prediction of 
      all-cause mortality, in men, 6MWD, 6MWS and PP all have comparable area under 
      curve (AUC) values compared with VO2 peak: 0.736, 0.723, 0.736 and 0.734 
      respectively. Similar results were observed for women, although all the AUC 
      values were slightly lower (corresponding values were 0.723, 0.713, 0.702 and 
      0.747 respectively). For cardiovascular mortality, the findings are similar 
      although in men all AUC values were higher. We conclude that PP predicts 7 year 
      all-cause and cardiovascular mortality in older adults with an accuracy similar 
      to VO2 peak, 6MWD and 6MWS, although the association is less strong in women.
CI  - Copyright (c) 2019 Elsevier Inc. All rights reserved.
FAU - Woo, Jean
AU  - Woo J
AD  - Department of Medicine and Therapeutics, The Chinese University of Hong Kong, 
      Hong Kong. Electronic address: jeanwoowong@cuhk.edu.hk.
FAU - Yau, Forrest
AU  - Yau F
AD  - Department of Medicine and Therapeutics, The Chinese University of Hong Kong, 
      Hong Kong.
FAU - Leung, Jason
AU  - Leung J
AD  - The Jockey Club Centre for Osteoporosis Care and Control, The Chinese University 
      of Hong Kong, Hong Kong.
FAU - Chan, Ruth
AU  - Chan R
AD  - Department of Medicine and Therapeutics, The Chinese University of Hong Kong, 
      Hong Kong.
LA  - eng
PT  - Journal Article
DEP - 20190625
PL  - England
TA  - Exp Gerontol
JT  - Experimental gerontology
JID - 0047061
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - *Blood Pressure
MH  - Body Mass Index
MH  - Cardiorespiratory Fitness
MH  - Cardiovascular Diseases/*mortality/physiopathology
MH  - Exercise Tolerance
MH  - Female
MH  - Hong Kong/epidemiology
MH  - Humans
MH  - Male
MH  - *Mortality
MH  - *Oxygen Consumption
MH  - Predictive Value of Tests
MH  - ROC Curve
MH  - *Walk Test
MH  - *Walking Speed
OTO - NOTNLM
OT  - 6-minute walk test
OT  - Cardiorespiratory fitness
OT  - Mortality
OT  - Pulse pressure
OT  - Walking speed
EDAT- 2019/06/30 06:00
MHDA- 2020/09/12 06:00
CRDT- 2019/06/29 06:00
PHST- 2018/12/06 00:00 [received]
PHST- 2019/06/24 00:00 [revised]
PHST- 2019/06/24 00:00 [accepted]
PHST- 2019/06/30 06:00 [pubmed]
PHST- 2020/09/12 06:00 [medline]
PHST- 2019/06/29 06:00 [entrez]
AID - S0531-5565(18)30787-3 [pii]
AID - 10.1016/j.exger.2019.110645 [doi]
PST - ppublish
SO  - Exp Gerontol. 2019 Sep;124:110645. doi: 10.1016/j.exger.2019.110645. Epub 2019 
      Jun 25.