PMID- 31252610
OWN - NLM
STAT- MEDLINE
DCOM- 20191206
LR  - 20200225
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 20
IP  - 13
DP  - 2019 Jun 27
TI  - Dysregulation of Epigenetic Mechanisms of Gene Expression in the Pathologies of 
      Hyperhomocysteinemia.
LID - 10.3390/ijms20133140 [doi]
LID - 3140
AB  - Hyperhomocysteinemia (HHcy) exerts a wide range of biological effects and is 
      associated with a number of diseases, including cardiovascular disease, dementia, 
      neural tube defects, and cancer. Although mechanisms of HHcy toxicity are not 
      fully uncovered, there has been a significant progress in their understanding. 
      The picture emerging from the studies of homocysteine (Hcy) metabolism and 
      pathophysiology is a complex one, as Hcy and its metabolites affect biomolecules 
      and processes in a tissue- and sex-specific manner. Because of their connection 
      to one carbon metabolism and editing mechanisms in protein biosynthesis, Hcy and 
      its metabolites impair epigenetic control of gene expression mediated by DNA 
      methylation, histone modifications, and non-coding RNA, which underlies the 
      pathology of human disease. In this review we summarize the recent evidence 
      showing that epigenetic dysregulation of gene expression, mediated by changes in 
      DNA methylation and histone N-homocysteinylation, is a pathogenic consequence of 
      HHcy in many human diseases. These findings provide new insights into the 
      mechanisms of human disease induced by Hcy and its metabolites, and suggest 
      therapeutic targets for the prevention and/or treatment.
FAU - Perla-Kajan, Joanna
AU  - Perla-Kajan J
AUID- ORCID: 0000-0002-0791-5057
AD  - Department of Biochemistry and Biotechnology, Poznan University of Life Sciences, 
      60-637 Poznan, Poland. kajan@up.poznan.pl.
FAU - Jakubowski, Hieronim
AU  - Jakubowski H
AUID- ORCID: 0000-0001-5845-4409
AD  - Department of Biochemistry and Biotechnology, Poznan University of Life Sciences, 
      60-637 Poznan, Poland. jakubows@rutgers.edu.
AD  - Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers-New 
      Jersey Medical School, International Center for Public Health, Newark, NJ 07103, 
      USA. jakubows@rutgers.edu.
LA  - eng
GR  - 2013/11/B/NZ1/00091/Narodowe Centrum Nauki/
GR  - 2014/15/B/NZ2/01079/Narodowe Centrum Nauki/
GR  - 2015/17/D/NZ5/03444/Narodowe Centrum Nauki/
GR  - 2016/23/B/NZ5/00573/Narodowe Centrum Nauki/
GR  - 2018/29/B/NZ4/00771/Narodowe Centrum Nauki/
GR  - 17GRNT32910002/American Heart Association/
PT  - Journal Article
PT  - Review
DEP - 20190627
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (RNA, Untranslated)
RN  - 0LVT1QZ0BA (Homocysteine)
SB  - IM
MH  - Animals
MH  - DNA Methylation
MH  - *Epigenesis, Genetic
MH  - Histone Code
MH  - Homocysteine/metabolism
MH  - Humans
MH  - Hyperhomocysteinemia/*genetics/metabolism
MH  - RNA, Untranslated/genetics
PMC - PMC6651274
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - DNA methylation
OT  - N-homocysteinylation
OT  - atherosclerosis
OT  - epigenetic
OT  - gene expression
OT  - histone
OT  - homocysteine thiolactone
OT  - hyperhomocysteinemia
OT  - miRNA
COIS- The authors declare no conflict of interest.
EDAT- 2019/06/30 06:00
MHDA- 2019/12/18 06:00
PMCR- 2019/07/01
CRDT- 2019/06/30 06:00
PHST- 2019/05/31 00:00 [received]
PHST- 2019/06/21 00:00 [revised]
PHST- 2019/06/25 00:00 [accepted]
PHST- 2019/06/30 06:00 [entrez]
PHST- 2019/06/30 06:00 [pubmed]
PHST- 2019/12/18 06:00 [medline]
PHST- 2019/07/01 00:00 [pmc-release]
AID - ijms20133140 [pii]
AID - ijms-20-03140 [pii]
AID - 10.3390/ijms20133140 [doi]
PST - epublish
SO  - Int J Mol Sci. 2019 Jun 27;20(13):3140. doi: 10.3390/ijms20133140.