PMID- 31253526
OWN - NLM
STAT- MEDLINE
DCOM- 20200625
LR  - 20200625
IS  - 1874-1754 (Electronic)
IS  - 0167-5273 (Linking)
VI  - 292
DP  - 2019 Oct 1
TI  - Serum free light chains in patients with ST elevation myocardial infarction 
      (STEMI): A possible correlation with left ventricle dysfunction.
PG  - 32-34
LID - S0167-5273(19)30221-9 [pii]
LID - 10.1016/j.ijcard.2019.06.016 [doi]
AB  - BACKGROUND: Light chains are proteins produced by plasma cells, also called light 
      chains kappa and lambda, are tied together with other proteins (heavy chains) to 
      form the intact immunoglobulins or antibodies. Recent studies have shown a 
      possible role of combined free light chains (cFLC) as an inflammatory marker in 
      patients with chronic heart failure (HF). HF is a significant contributor to 
      overall mortality in the community, but often patients with chronic HF also have 
      chronic renal failure, which could alter the concentration of cFLC. METHODS: We 
      evaluated the FLC in patients with STEMI (n = 113), who were treated with primary 
      angioplasty in the Cardiology Department of the University Hospital "Tor 
      Vergata". For each patient during hospitalization we have determined blood 
      concentration of cFLC, in addition to routine blood tests and we also performed 
      an echocardiogram to evaluate cardiac function. RESULTS: We performed cFLC serum 
      concentration in 113 patients with STEMI and observed that the cFLC concentration 
      correlates with Left Ventricle Ejection Fraction (LVEF). We identified that the 
      majority of patients (97%) who had one of the two positive light chains also had 
      a reduced systolic function (LVEF <50%). CONCLUSIONS: For the first time in this 
      paper we highlight the increase of serum free light chains concentrations in 
      acute ischemic heart failure in patients with STEMI and without kidney failure. 
      The cFLC could be proposed as a new biomarker for left ventricle dysfunction, 
      further studies are required to confirm these results.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Perrone, Marco Alfonso
AU  - Perrone MA
AD  - Division of Cardiology, University of Rome Tor Vergata, Rome, Italy. Electronic 
      address: marco.perrone01@gmail.com.
FAU - Pieri, Massimo
AU  - Pieri M
AD  - Division of Clinical Biochemistry and Clinical Molecular Biology, University of 
      Rome Tor Vergata, Rome, Italy.
FAU - Marchei, Massimo
AU  - Marchei M
AD  - Division of Cardiology, University of Rome Tor Vergata, Rome, Italy.
FAU - Sergi, Domenico
AU  - Sergi D
AD  - Division of Cardiology, University of Rome Tor Vergata, Rome, Italy.
FAU - Bernardini, Sergio
AU  - Bernardini S
AD  - Division of Clinical Biochemistry and Clinical Molecular Biology, University of 
      Rome Tor Vergata, Rome, Italy.
FAU - Romeo, Francesco
AU  - Romeo F
AD  - Division of Cardiology, University of Rome Tor Vergata, Rome, Italy.
LA  - eng
PT  - Journal Article
DEP - 20190612
PL  - Netherlands
TA  - Int J Cardiol
JT  - International journal of cardiology
JID - 8200291
RN  - 0 (Immunoglobulin Light Chains)
SB  - IM
MH  - Correlation of Data
MH  - Heart Failure/blood/complications
MH  - Humans
MH  - Immunoglobulin Light Chains/*blood
MH  - ST Elevation Myocardial Infarction/*blood/*complications
MH  - Ventricular Dysfunction, Left/*blood/*complications
OTO - NOTNLM
OT  - Free light chains
OT  - Heart failure
OT  - Left ventricle dysfunction
OT  - STEMI
EDAT- 2019/06/30 06:00
MHDA- 2020/06/26 06:00
CRDT- 2019/06/30 06:00
PHST- 2019/01/12 00:00 [received]
PHST- 2019/05/25 00:00 [revised]
PHST- 2019/06/10 00:00 [accepted]
PHST- 2019/06/30 06:00 [pubmed]
PHST- 2020/06/26 06:00 [medline]
PHST- 2019/06/30 06:00 [entrez]
AID - S0167-5273(19)30221-9 [pii]
AID - 10.1016/j.ijcard.2019.06.016 [doi]
PST - ppublish
SO  - Int J Cardiol. 2019 Oct 1;292:32-34. doi: 10.1016/j.ijcard.2019.06.016. Epub 2019 
      Jun 12.