PMID- 31254137
OWN - NLM
STAT- MEDLINE
DCOM- 20200421
LR  - 20200421
IS  - 1568-5608 (Electronic)
IS  - 0925-4692 (Linking)
VI  - 27
IP  - 6
DP  - 2019 Dec
TI  - Preemptive meloxicam achieves a better effect on postoperative pain control and 
      similar tolerance compared with postoperative meloxicam in patients receiving 
      arthroscopic knee surgery.
PG  - 1091-1100
LID - 10.1007/s10787-019-00614-4 [doi]
AB  - This study aimed to compare the efficacy and safety of very early preemptive 
      meloxicam, early preemptive meloxicam, and postoperative meloxicam administration 
      for postoperative pain relief in patients undergoing arthroscopic knee surgery 
      (AKS). Three hundred and six patients about to receive AKS were consecutively 
      enrolled in this randomized, controlled study and randomly allocated into three 
      groups: very early analgesia (VEA) group, early analgesia (EA) group, and 
      postoperative analgesia (PA) group. Pain visual analog scale (VAS) score at rest 
      and at flexion, patient global assessment (PGA) score, consumption of rescue 
      pethidine, and adverse events (AEs) were assessed. Pain VAS score and severity at 
      rest/flexion were all decreased in the VEA group compared with EA group and PA 
      group at 4 h post-operation and were also reduced in the VEA and EA groups 
      compared with the PA group at 8 h and 12 h post-operation. PGA score was lower in 
      the VEA group compared with the EA group and PA group at 4 h post-operation, and 
      was attenuated in the VEA group and the EA group compared with the PA group at 
      8 h, 12 h, and 24 h post-operation as well. Consumption of rescue pethidine was 
      less in the VEA group than that in the PA group. In addition, no difference in 
      the incidence of AEs was found among the VEA, EA, and PA groups. In conclusion, 
      preemptive meloxicam is more effective in postoperative pain control and equally 
      tolerated compared with postoperative meloxicam in patients receiving AKS.
FAU - Yuan, Yanxin
AU  - Yuan Y
AD  - Department of Anesthesiology, Daqing Oilfield General Hospital, Daqing, China.
FAU - Cui, Dan
AU  - Cui D
AD  - Department of Anesthesiology, Daqing Oilfield General Hospital, Daqing, China.
FAU - Zhang, Yunhong
AU  - Zhang Y
AD  - Department of Anesthesiology, Daqing Longnan Hospital, 35 Aiguo Road, Ranghu Road 
      District, Daqing, 163453, China. yidouhui6k@163.com.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20190628
PL  - Switzerland
TA  - Inflammopharmacology
JT  - Inflammopharmacology
JID - 9112626
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 9E338QE28F (Meperidine)
RN  - VG2QF83CGL (Meloxicam)
SB  - IM
MH  - Adult
MH  - Anti-Inflammatory Agents, Non-Steroidal/*therapeutic use
MH  - Arthroscopy/*methods
MH  - Female
MH  - Humans
MH  - Knee Joint/*surgery
MH  - Male
MH  - Meloxicam/administration & dosage/adverse effects/*therapeutic use
MH  - Meperidine/therapeutic use
MH  - Pain Measurement
MH  - Pain, Postoperative/*drug therapy
OTO - NOTNLM
OT  - Arthroscopic knee surgery
OT  - Efficacy
OT  - Meloxicam
OT  - Preemptive analgesia
OT  - Safety
EDAT- 2019/06/30 06:00
MHDA- 2020/04/22 06:00
CRDT- 2019/06/30 06:00
PHST- 2019/04/30 00:00 [received]
PHST- 2019/06/16 00:00 [accepted]
PHST- 2019/06/30 06:00 [pubmed]
PHST- 2020/04/22 06:00 [medline]
PHST- 2019/06/30 06:00 [entrez]
AID - 10.1007/s10787-019-00614-4 [pii]
AID - 10.1007/s10787-019-00614-4 [doi]
PST - ppublish
SO  - Inflammopharmacology. 2019 Dec;27(6):1091-1100. doi: 10.1007/s10787-019-00614-4. 
      Epub 2019 Jun 28.