PMID- 31254396
OWN - NLM
STAT- MEDLINE
DCOM- 20200702
LR  - 20231213
IS  - 1096-9071 (Electronic)
IS  - 0146-6615 (Linking)
VI  - 91
IP  - 10
DP  - 2019 Oct
TI  - Association of HLA-DQB1*03:01 and DRB1*11:01 with spontaneous clearance of 
      hepatitis C virus in Chinese Li ethnicity, an ethnic group genetically distinct 
      from Chinese Han ethnicity and infected with unique HCV subtype.
PG  - 1830-1836
LID - 10.1002/jmv.25531 [doi]
AB  - Specific human leukocyte antigen (HLA) class I and class II alleles have been 
      associated with spontaneous clearance or persistent infection of hepatitis C 
      virus (HCV), which seemed to be restricted by the host's ethnicity and viral 
      genotype. Recently we reported a high prevalence and spontaneous clearance rate 
      of HCV in a cohort of Chinese Li ethnicity who were infected with new variants of 
      HCV genotype 6. In this study, we found that the distribution of HLA class I and 
      class II alleles in HCV infected individuals of Chinese Li ethnicity (n = 143) 
      was distinct from that of Chinese Han ethnicity which was reported in our 
      previous study. HLA-DRB1*11:01 and DQB1*03:01 were more prevalent in Chinese Li 
      subjects who cleared HCV spontaneously than those who were chronically infected 
      (P = .036 and P = .024, respectively), which were consistent with our previous 
      report regarding the Chinese Han population. Multivariate logistic regression 
      analysis showed that DQB1*03:01 (odds ratio = 3.899, P = .017), but not 
      DRB1*11:01, associated with HCV spontaneous clearance, independent of age, sex, 
      and IFNL3 genotype. Because DQB1*03:01 and DRB1*11:01 were tightly linked because 
      of linkage disequilibrium, our results clearly supported the associations of 
      these two alleles with HCV spontaneous clearance in Chinese Li as well as Han 
      ethnicity.
CI  - (c) 2019 Wiley Periodicals, Inc.
FAU - Huang, Jieting
AU  - Huang J
AUID- ORCID: 0000-0002-2886-9344
AD  - Guangzhou Blood Center, Guangzhou, Guangdong, China.
AD  - The Key Medical Laboratory of Guangzhou, Guangzhou, Guangdong, China.
FAU - Xu, Ru
AU  - Xu R
AD  - Guangzhou Blood Center, Guangzhou, Guangdong, China.
AD  - The Key Medical Laboratory of Guangzhou, Guangzhou, Guangdong, China.
FAU - Wang, Min
AU  - Wang M
AD  - Guangzhou Blood Center, Guangzhou, Guangdong, China.
AD  - The Key Medical Laboratory of Guangzhou, Guangzhou, Guangdong, China.
FAU - Liao, Qiao
AU  - Liao Q
AUID- ORCID: 0000-0002-1422-6161
AD  - Guangzhou Blood Center, Guangzhou, Guangdong, China.
AD  - The Key Medical Laboratory of Guangzhou, Guangzhou, Guangdong, China.
FAU - Huang, Ke
AU  - Huang K
AD  - Guangzhou Blood Center, Guangzhou, Guangdong, China.
AD  - The Key Medical Laboratory of Guangzhou, Guangzhou, Guangdong, China.
FAU - Shan, Zhengang
AU  - Shan Z
AD  - Guangzhou Blood Center, Guangzhou, Guangdong, China.
AD  - The Key Medical Laboratory of Guangzhou, Guangzhou, Guangdong, China.
FAU - You, Qingzhu
AU  - You Q
AD  - Department of Transfusion Medicine, School of Biotechnology, Southern Medical 
      University, Guangzhou, Guangdong, China.
FAU - Li, Chengyao
AU  - Li C
AUID- ORCID: 0000-0002-2087-873X
AD  - Department of Transfusion Medicine, School of Biotechnology, Southern Medical 
      University, Guangzhou, Guangdong, China.
FAU - Rong, Xia
AU  - Rong X
AD  - Guangzhou Blood Center, Guangzhou, Guangdong, China.
AD  - The Key Medical Laboratory of Guangzhou, Guangzhou, Guangdong, China.
AD  - Department of Transfusion Medicine, School of Biotechnology, Southern Medical 
      University, Guangzhou, Guangdong, China.
FAU - Fu, Yongshui
AU  - Fu Y
AD  - Guangzhou Blood Center, Guangzhou, Guangdong, China.
AD  - The Key Medical Laboratory of Guangzhou, Guangzhou, Guangdong, China.
AD  - Department of Transfusion Medicine, School of Biotechnology, Southern Medical 
      University, Guangzhou, Guangdong, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190705
PL  - United States
TA  - J Med Virol
JT  - Journal of medical virology
JID - 7705876
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (interferon-lambda, human)
RN  - 9008-11-1 (Interferons)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Alleles
MH  - Asian People/*genetics
MH  - China
MH  - Ethnicity
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA-DQ beta-Chains/genetics/*metabolism
MH  - HLA-DRB1 Chains/genetics/*metabolism
MH  - Hepacivirus/*immunology
MH  - Hepatitis C, Chronic/genetics/*immunology
MH  - Humans
MH  - Interferons/genetics
MH  - Male
MH  - Polymorphism, Single Nucleotide
OTO - NOTNLM
OT  - genotype
OT  - hepatitis C virus
OT  - human leukocyte antigen
OT  - race
OT  - self-resolved infection
EDAT- 2019/06/30 06:00
MHDA- 2020/07/03 06:00
CRDT- 2019/06/30 06:00
PHST- 2019/02/01 00:00 [received]
PHST- 2019/06/21 00:00 [accepted]
PHST- 2019/06/30 06:00 [pubmed]
PHST- 2020/07/03 06:00 [medline]
PHST- 2019/06/30 06:00 [entrez]
AID - 10.1002/jmv.25531 [doi]
PST - ppublish
SO  - J Med Virol. 2019 Oct;91(10):1830-1836. doi: 10.1002/jmv.25531. Epub 2019 Jul 5.