PMID- 31254955 OWN - NLM STAT- MEDLINE DCOM- 20200217 LR - 20200217 IS - 1878-1705 (Electronic) IS - 1567-5769 (Linking) VI - 74 DP - 2019 Sep TI - Anti-inflammatory effects of linalool on ovalbumin-induced pulmonary inflammation. PG - 105706 LID - S1567-5769(19)30128-6 [pii] LID - 10.1016/j.intimp.2019.105706 [doi] AB - Linalool is a natural product present in fruits and aromatic plants with biological activities. Researchers have reported that the inhalation of linalool exerts anti-inflammatory activities. In this study, we examined the therapeutic effects of linalool on airway inflammation and mucus overproduction in mice with allergic asthma. Oral administration of linalool significantly inhibited the levels of eosinophil numbers, Th2 cytokines and immunoglobulin E (IgE) caused by ovalbumin (OVA) exposure. Linalool exerted preventive effects against the influx of inflammatory cells and mucus hypersecretion in the lung tissues. Linalool also dose-dependently decreased the levels of inducible nitric oxide synthase (iNOS) expression and protein kinase B (AKT) activation in the lung tissues. Linalool effectively downregulated the activation of mitogen-activated protein kinases (MAPKs) and nuclear factor-kappaB (NF-kappaB) caused by OVA exposure. Furthermore, linalool exerted inhibitory effect on OVA-induced airway hyperresponsiveness (AHR). In the in vitro study, the increased secretion of MCP-1 was attenuated with linalool treatment in lipopolysaccharide (LPS)-stimulated H292 airway epithelial cells. In conclusion, linalool effectively exerts a protective role in OVA-induced airway inflammation and mucus hypersecretion, and its protective effects are closely related to the downregulation of inflammatory mediators and MAPKs/NF-kappaB signaling. CI - Copyright (c) 2019 Elsevier B.V. All rights reserved. FAU - Kim, Min-Gu AU - Kim MG AD - Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju-si, Chungcheongbuk-do 28116, Republic of Korea; College of Pharmacy, Chungbuk National University, Cheongju-si, Chungcheongbuk-do 28160, Republic of Korea. FAU - Kim, Seong-Man AU - Kim SM AD - Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju-si, Chungcheongbuk-do 28116, Republic of Korea; College of Pharmacy, Chungnam National University, 99 Daehak-ro, Yuseong-gu, Daejeon, 305-764, Republic of Korea. FAU - Min, Jae-Hong AU - Min JH AD - Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju-si, Chungcheongbuk-do 28116, Republic of Korea. FAU - Kwon, Ok-Kyoung AU - Kwon OK AD - Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju-si, Chungcheongbuk-do 28116, Republic of Korea. FAU - Park, Mi-Hyeong AU - Park MH AD - Laboratory Animal Resources Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Osong Health Technology Administration Complex, Cheongju, Chungcheongbuk 28159, Republic of Korea. FAU - Park, Ji-Won AU - Park JW AD - Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju-si, Chungcheongbuk-do 28116, Republic of Korea. FAU - Ahn, Hye In AU - Ahn HI AD - Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju-si, Chungcheongbuk-do 28116, Republic of Korea. FAU - Hwang, Jeong-Yeon AU - Hwang JY AD - Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju-si, Chungcheongbuk-do 28116, Republic of Korea; College of Pharmacy, Chungbuk National University, Cheongju-si, Chungcheongbuk-do 28160, Republic of Korea. FAU - Oh, Sei-Raying AU - Oh SR AD - Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju-si, Chungcheongbuk-do 28116, Republic of Korea. FAU - Lee, Jae-Won AU - Lee JW AD - Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju-si, Chungcheongbuk-do 28116, Republic of Korea. Electronic address: suc369@kribb.re.kr. FAU - Ahn, Kyung-Seop AU - Ahn KS AD - Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju-si, Chungcheongbuk-do 28116, Republic of Korea. Electronic address: ksahn@kribb.re.kr. LA - eng PT - Journal Article DEP - 20190626 PL - Netherlands TA - Int Immunopharmacol JT - International immunopharmacology JID - 100965259 RN - 0 (Acyclic Monoterpenes) RN - 0 (Allergens) RN - 0 (Anti-Inflammatory Agents) RN - 0 (Cytokines) RN - 0 (NF-kappa B) RN - 37341-29-0 (Immunoglobulin E) RN - 9006-59-1 (Ovalbumin) RN - D81QY6I88E (linalool) RN - EC 1.14.13.39 (Nitric Oxide Synthase Type II) SB - IM MH - Acyclic Monoterpenes/*therapeutic use MH - Administration, Oral MH - Allergens/immunology MH - Animals MH - Anti-Inflammatory Agents/*therapeutic use MH - Asthma/*drug therapy MH - Cells, Cultured MH - Cytokines/metabolism MH - Disease Models, Animal MH - Female MH - Humans MH - Hypersensitivity/*drug therapy MH - Immunoglobulin E/metabolism MH - Lung/*metabolism/pathology MH - Mice MH - Mice, Inbred BALB C MH - NF-kappa B/metabolism MH - Nitric Oxide Synthase Type II/metabolism MH - Ovalbumin/immunology MH - Respiratory Hypersensitivity/*drug therapy MH - Respiratory Mucosa/metabolism/pathology MH - Th2 Cells/*immunology OTO - NOTNLM OT - Allergic asthma OT - Eosinophil OT - Linalool OT - Mucus OT - NF-kappaB OT - Th2 cytokines EDAT- 2019/06/30 06:00 MHDA- 2020/02/18 06:00 CRDT- 2019/06/30 06:00 PHST- 2019/01/18 00:00 [received] PHST- 2019/06/13 00:00 [revised] PHST- 2019/06/14 00:00 [accepted] PHST- 2019/06/30 06:00 [pubmed] PHST- 2020/02/18 06:00 [medline] PHST- 2019/06/30 06:00 [entrez] AID - S1567-5769(19)30128-6 [pii] AID - 10.1016/j.intimp.2019.105706 [doi] PST - ppublish SO - Int Immunopharmacol. 2019 Sep;74:105706. doi: 10.1016/j.intimp.2019.105706. Epub 2019 Jun 26.