PMID- 31255433
OWN - NLM
STAT- MEDLINE
DCOM- 20201105
LR  - 20201105
IS  - 1873-460X (Electronic)
IS  - 1056-8727 (Linking)
VI  - 33
IP  - 9
DP  - 2019 Sep
TI  - Increased cardio-ankle vascular index is independently associated with chronic 
      kidney disease: A cross-sectional study in Chinese patients with type 2 diabetes 
      mellitus.
PG  - 623-627
LID - S1056-8727(19)30137-0 [pii]
LID - 10.1016/j.jdiacomp.2019.05.009 [doi]
AB  - AIMS: This cross-sectional study aimed to investigate the association between 
      arterial stiffness and chronic kidney disease (CKD) in Chinese patients with type 
      2 diabetes mellitus (T2DM). METHODS: This study included 1025 patients with T2DM 
      (796 men, 229 women). The cardio-ankle vascular index (CAVI) served as an index 
      to evaluate arterial stiffness. CKD was defined as an estimated glomerular 
      filtration rate < 60 mL/min/1.73 m(2) and/or urinary albumin-creatine 
      ratio >/= 30 mg/g. Increased CAVI was defined as a value >/=9. RESULTS: The mean CAVI 
      was 8.4 +/- 1.2. Among the patients, 314 (40%) had increased CAVI and 229 (22.3%) 
      had CKD. Blood pressure, HbA1c levels, total cholesterol, low-density lipoprotein 
      cholesterol, uric acid and CAVI were higher among patients with CKD than among 
      those without CKD. Patients with increased CAVI were at a 1.82-fold (95% CI, 
      1.20-2.75; P < 0.001) higher prevalence of CKD after adjusting for other 
      variables. The odds ratio for CKD was 2.69 (95% CI, 1.12-6.47; P = 0.027) in 
      women and 1.62 (95% CI, 1.01-2.61; P = 0.045) in men. CONCLUSION: Increased CAVI 
      was independently associated with CKD in patients with T2DM. Further longitudinal 
      studies with large sample sizes are warranted to investigate the effect of CAVI 
      on CKD in patients with T2DM.
CI  - Copyright (c) 2019 Elsevier Inc. All rights reserved.
FAU - Zhang, Chenghui
AU  - Zhang C
AD  - Department of Endocrinology and Metabolism, West China Hospital, Sichuan 
      University, Chengdu 610041, China.
FAU - Zhong, Yajun
AU  - Zhong Y
AD  - Department of Endocrinology and Metabolism, West China Hospital, Sichuan 
      University, Chengdu 610041, China.
FAU - Tian, Haoming
AU  - Tian H
AD  - Department of Endocrinology and Metabolism, West China Hospital, Sichuan 
      University, Chengdu 610041, China. Electronic address: HaomingTianscu@163.com.
LA  - eng
PT  - Journal Article
DEP - 20190517
PL  - United States
TA  - J Diabetes Complications
JT  - Journal of diabetes and its complications
JID - 9204583
RN  - EC 3.5.3.- (Ureohydrolases)
RN  - EC 3.5.3.3 (creatinase)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Albuminuria
MH  - *Ankle Brachial Index
MH  - China/epidemiology
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/complications/*physiopathology
MH  - Female
MH  - Glomerular Filtration Rate
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Renal Insufficiency, Chronic/diagnosis/*epidemiology/etiology
MH  - Ureohydrolases/urine
MH  - Vascular Stiffness/*physiology
OTO - NOTNLM
OT  - Arterial stiffness
OT  - Cardio-ankle vascular index
OT  - Chronic kidney disease
OT  - Pulse wave velocity
OT  - Type 2 diabetes mellitus
EDAT- 2019/07/01 06:00
MHDA- 2020/11/06 06:00
CRDT- 2019/07/01 06:00
PHST- 2019/02/07 00:00 [received]
PHST- 2019/05/08 00:00 [revised]
PHST- 2019/05/11 00:00 [accepted]
PHST- 2019/07/01 06:00 [pubmed]
PHST- 2020/11/06 06:00 [medline]
PHST- 2019/07/01 06:00 [entrez]
AID - S1056-8727(19)30137-0 [pii]
AID - 10.1016/j.jdiacomp.2019.05.009 [doi]
PST - ppublish
SO  - J Diabetes Complications. 2019 Sep;33(9):623-627. doi: 
      10.1016/j.jdiacomp.2019.05.009. Epub 2019 May 17.