PMID- 31255949
OWN - NLM
STAT- MEDLINE
DCOM- 20200430
LR  - 20200430
IS  - 1096-0953 (Electronic)
IS  - 0013-9351 (Linking)
VI  - 176
DP  - 2019 Sep
TI  - Prenatal selenium status, neonatal cerebellum measures and child neurodevelopment 
      at the age of 18 months.
PG  - 108529
LID - S0013-9351(19)30326-3 [pii]
LID - 10.1016/j.envres.2019.108529 [doi]
AB  - OBJECTIVES: The aim of this study was to evaluate the association of maternal 
      blood selenium (Se) levels and cord blood Se levels with neonatal cerebellum 
      measures and child neurodevelopment at the age of 18 months. Moreover, to 
      investigate whether the neonatal cerebellum measures could be used as a potential 
      biomarker for selenium homeostasis during pregnancy. STUDY GROUP AND METHODS: The 
      study population consisted of 205 mother-child pairs from Croatian Mother and 
      Child Cohort. Maternal blood and cord blood were obtained at delivery and 
      selenium level was analyzed by Inductively Coupled Plasma Mass Spectrometry. 
      Cranial ultrasonography examination was performed on 49 newborns - cerebellum 
      length and width have been measured. Neurodevelopmental assessment of cognitive, 
      language and motor skills were conducted on 154 children, using The Bayley Scales 
      of Infant and Toddler Development, Third Edition (BSID-III), at the age of 18 
      months. RESULTS: The mean levels of selenium in maternal blood and cord blood 
      were 92.6 ng/g and 97.0 ng/g, respectively. Maternal blood selenium levels were 
      moderately and negatively correlated (r = -0.372; p = 0.008) with cerebellum 
      length, while cord blood selenium levels were positively correlated with 
      cerebellum width (r = 0.613; p = 0.007) among female children group. Maternal 
      blood selenium levels were weakly and positively correlated (r = 0.176; 
      p = 0.029) with child's cognitive abilities. CONCLUSION: To the best of our 
      knowledge, our study is the first one investigating the association between 
      neonatal brain measures and selenium levels in mother-child pairs. Our results 
      indicate that prenatal selenium intake correlated with cerebellum length and 
      width measured by cranial ultrasonography. Hence, cerebellum may be used as a 
      potential biomarker and a target "organ" for early detection of possible adverse 
      effects of prenatal status to various micronutrients.
CI  - Copyright (c) 2019. Published by Elsevier Inc.
FAU - Mocenic, Ivona
AU  - Mocenic I
AD  - Department of Pediatrics, General Hospital Pula, Zagrebacka 30, 52100, Pula, 
      Croatia.
FAU - Kolic, Ivana
AU  - Kolic I
AD  - University Hospital Centre Rijeka, Department of Pediatrics, Istarska 43, 51000, 
      Rijeka, Croatia.
FAU - Nisevic, Jelena Radic
AU  - Nisevic JR
AD  - University Hospital Centre Rijeka, Department of Pediatrics, Istarska 43, 51000, 
      Rijeka, Croatia; University of Rijeka, Faculty of Medicine, Brace Branchetta 20, 
      51000, Rijeka, Croatia.
FAU - Belancic, Andrej
AU  - Belancic A
AD  - University of Rijeka, Faculty of Medicine, Brace Branchetta 20, 51000, Rijeka, 
      Croatia.
FAU - Tratnik, Janja Snoj
AU  - Tratnik JS
AD  - Institute "Jozef Stefan", Department of Environmental Sciences, Jamova 39, 1000, 
      Ljubljana, Slovenia.
FAU - Mazej, Darja
AU  - Mazej D
AD  - Institute "Jozef Stefan", Department of Environmental Sciences, Jamova 39, 1000, 
      Ljubljana, Slovenia.
FAU - Falnoga, Ingrid
AU  - Falnoga I
AD  - Institute "Jozef Stefan", Department of Environmental Sciences, Jamova 39, 1000, 
      Ljubljana, Slovenia.
FAU - Vlasic-Cicvaric, Inge
AU  - Vlasic-Cicvaric I
AD  - University Hospital Centre Rijeka, Centre for Clinical, Health and Organizational 
      Psychology, Istarska 43, 51000, Rijeka, Croatia.
FAU - Stimac, Tea
AU  - Stimac T
AD  - University of Rijeka, Faculty of Medicine, Brace Branchetta 20, 51000, Rijeka, 
      Croatia; University Hospital Centre Rijeka, Department of Gynecology and 
      Obstetrics, Kresimirova 42, 51000, Rijeka, Croatia.
FAU - Spiric, Zdravko
AU  - Spiric Z
AD  - University of Rijeka, Faculty of Medicine, Brace Branchetta 20, 51000, Rijeka, 
      Croatia; Green Infrastructure Ltd., Fallerovo setaliste 22, 10000, Zagreb, 
      Croatia.
FAU - Horvat, Milena
AU  - Horvat M
AD  - Institute "Jozef Stefan", Department of Environmental Sciences, Jamova 39, 1000, 
      Ljubljana, Slovenia.
FAU - Prpic, Igor
AU  - Prpic I
AD  - University Hospital Centre Rijeka, Department of Pediatrics, Istarska 43, 51000, 
      Rijeka, Croatia; University of Rijeka, Faculty of Medicine, Brace Branchetta 20, 
      51000, Rijeka, Croatia; Corresponding author. University Hospital Centre Rijeka, 
      Department of Pediatrics, Istarska 43, 51000, Rijeka, Croatia. Electronic 
      address: igor.prpic@medri.uniri.hr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190608
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
RN  - 0 (Environmental Pollutants)
RN  - H6241UJ22B (Selenium)
SB  - IM
MH  - Cerebellum/*anatomy & histology
MH  - Child Development
MH  - Environmental Exposure/*statistics & numerical data
MH  - *Environmental Pollutants
MH  - Female
MH  - Fetal Blood
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Neurodevelopmental Disorders/*epidemiology
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects
MH  - *Selenium
OTO - NOTNLM
OT  - Biomarkers
OT  - Brain
OT  - Cerebellum
OT  - Neurodevelopment
OT  - Prenatal exposure delayed effects
OT  - Selenium
EDAT- 2019/07/01 06:00
MHDA- 2020/05/01 06:00
CRDT- 2019/07/01 06:00
PHST- 2019/04/24 00:00 [received]
PHST- 2019/06/06 00:00 [revised]
PHST- 2019/06/07 00:00 [accepted]
PHST- 2019/07/01 06:00 [pubmed]
PHST- 2020/05/01 06:00 [medline]
PHST- 2019/07/01 06:00 [entrez]
AID - S0013-9351(19)30326-3 [pii]
AID - 10.1016/j.envres.2019.108529 [doi]
PST - ppublish
SO  - Environ Res. 2019 Sep;176:108529. doi: 10.1016/j.envres.2019.108529. Epub 2019 
      Jun 8.