PMID- 31256165
OWN - NLM
STAT- MEDLINE
DCOM- 20191104
LR  - 20191104
IS  - 1423-0097 (Electronic)
IS  - 1018-2438 (Linking)
VI  - 180
IP  - 2
DP  - 2019
TI  - Long-Term Efficacy of Sublingual Mite Immunotherapy in Monosensitized and 
      Polysensitized Children with Allergic Rhinitis: A 7-Year Prospective Study.
PG  - 144-149
LID - 10.1159/000500524 [doi]
AB  - BACKGROUND: Several foreign studies have shown long-term efficacy of sublingual 
      immunotherapy (SLIT), but data on the long-term efficacy of SLIT in China are 
      still lacking. OBJECTIVE: We aimed to prospectively evaluate the long-term 
      efficacy of a 2-year SLIT with Dermatophagoides farinae(D. farinae) drops in 
      mono- and polysensitized children with allergic rhinitis (AR). METHODS: Eighty 
      house dust mite (HDM)-sensitized children (aged 4-11 years) with AR were enrolled 
      in this prospective study. There were 40 children in both the monosensitized (to 
      HDM only) and polysensitized groups. Both groups were treated with standardized 
      SLIT (D. farinae drops) for 2 years, combined with pharmacotherapy according to 
      their individual requirements, and were followed up for 7 years. A combined 
      symptom and medication score (CSMS) was assessed and compared between the 2 
      groups during and after SLIT. Safety was evaluated based on adverse events (AEs). 
      RESULTS: There were 31 (77.5%) monosensitized and 29 (72.5%) polysensitized 
      children who completed the study. After 2-year SLIT, the CSMS of 2 groups 
      significantly decreased compared to baseline. The improvement persisted during 
      the first 5 years at each visit, with a significant difference (all p < 0.01). In 
      the monosensitized group, the CSMS significantly increased during the 6th and the 
      7th year compared to year 2 (both p < 0.05). Meanwhile, the polysensitized group 
      showed a significant worsening of CSMS from the 5th to the 7th year (all p < 
      0.05). Furthermore, there was a statistical difference between the 2 groups in 
      the 5th year of the study (p < 0.05). No severe AEs were reported. CONCLUSIONS: 
      The study confirmed the long-term effects which lasted for 7 years after 2-year 
      SLIT in mono- and polysensitized children. Compared with the polysensitized 
      children, the monosensitized children noted a more sustained benefit.
CI  - (c) 2019 S. Karger AG, Basel.
FAU - Cui, Long
AU  - Cui L
AD  - Department of Otorhinolaryngology, Children's Hospital of Wuhan City, Wuhan, 
      China.
FAU - Li, Jun
AU  - Li J
AD  - Department of Otorhinolaryngology, Children's Hospital of Wuhan City, Wuhan, 
      China.
FAU - Li, Yong
AU  - Li Y
AD  - Department of Otorhinolaryngology, Affiliated Hangzhou First People's Hospital, 
      Zhejiang University School of Medicine, Hangzhou, China, leeyung828@sina.com.
FAU - Xia, Zhongfang
AU  - Xia Z
AD  - Department of Otorhinolaryngology, Children's Hospital of Wuhan City, Wuhan, 
      China.
LA  - eng
PT  - Journal Article
DEP - 20190628
PL  - Switzerland
TA  - Int Arch Allergy Immunol
JT  - International archives of allergy and immunology
JID - 9211652
RN  - 0 (Allergens)
RN  - 0 (Antigens, Dermatophagoides)
SB  - IM
MH  - Administration, Sublingual
MH  - Allergens/administration & dosage/immunology
MH  - Animals
MH  - Antigens, Dermatophagoides/*administration & dosage/*immunology
MH  - Child
MH  - Child, Preschool
MH  - China
MH  - Dermatophagoides farinae/*immunology
MH  - Female
MH  - Humans
MH  - Male
MH  - Prospective Studies
MH  - Rhinitis, Allergic/*therapy
MH  - Sublingual Immunotherapy/adverse effects/*methods
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Allergic rhinitis
OT  - Long-term efficacy
OT  - Monosensitization
OT  - Polysensitization
OT  - Sublingual immunotherapy
EDAT- 2019/07/01 06:00
MHDA- 2019/11/05 06:00
CRDT- 2019/07/01 06:00
PHST- 2019/02/24 00:00 [received]
PHST- 2019/04/23 00:00 [accepted]
PHST- 2019/07/01 06:00 [pubmed]
PHST- 2019/11/05 06:00 [medline]
PHST- 2019/07/01 06:00 [entrez]
AID - 000500524 [pii]
AID - 10.1159/000500524 [doi]
PST - ppublish
SO  - Int Arch Allergy Immunol. 2019;180(2):144-149. doi: 10.1159/000500524. Epub 2019 
      Jun 28.