PMID- 31256274
OWN - NLM
STAT- MEDLINE
DCOM- 20201126
LR  - 20221207
IS  - 1437-2320 (Electronic)
IS  - 0344-5607 (Linking)
VI  - 43
IP  - 4
DP  - 2020 Aug
TI  - Hyperhomocysteinemia is an independent risk factor for intracranial aneurysms: a 
      case-control study in a Chinese Han population.
PG  - 1127-1134
LID - 10.1007/s10143-019-01138-9 [doi]
AB  - Intracranial aneurysms (IAs) are common lesions in the brain. There is a strong 
      relation between hyperhomocysteinemia (HHcy) and cerebrovascular disease; we 
      perform a retrospective study within the Chinese Han population to explore the 
      association between HHcy and IAs. Two hundred six patients with IAs and 206 
      control subjects were evaluated for their serum total homocysteine levels. With 
      multiple logistic regression analysis, the association between HHcy and the risk 
      of IAs was estimated. Interaction and stratified analyses were conducted 
      according to age, sex, BMI, smoking status, drinking status, and chronic disease 
      histories. The threshold effect was examined by the two-piecewise linear 
      regression model. The multivariate logistic regression analyses revealed a 
      significant association between HHcy and IAs (odds ratio (OR) = 1.68; 95% 
      confidence interval (CI), 1.02-2.75) after adjusting for classical vascular risk 
      factors. And a 2% higher risk of IAs was observed, which was associated with a 
      1-mumol/L increase in serum total homocysteine level. The interaction analysis 
      showed that age played an interactive role in the association between HHcy and 
      IAs. In summary, our study provides evidence that HHcy is an independent risk 
      factor for IAs in the Chinese Han population, especially in the elderly subgroup. 
      Taking all the findings into consideration, longitudinal studies and clinical 
      trials of homocysteine-lowering therapy via dietary or medical intervention are 
      needed to assess the causal nature of these relationships.
FAU - Wang, Qun
AU  - Wang Q
AD  - Department of Neurosurgery, Chinese PLA General Hospital, 28 Fuxing Road, Haidian 
      District, Beijing, 100853, China.
FAU - Zhang, JiaShu
AU  - Zhang J
AD  - Department of Neurosurgery, Chinese PLA General Hospital, 28 Fuxing Road, Haidian 
      District, Beijing, 100853, China.
FAU - Zhao, Kai
AU  - Zhao K
AD  - Department of Neurosurgery, Chinese PLA General Hospital, 28 Fuxing Road, Haidian 
      District, Beijing, 100853, China.
FAU - Xu, BaiNan
AU  - Xu B
AUID- ORCID: 0000-0001-6897-0589
AD  - Department of Neurosurgery, Chinese PLA General Hospital, 28 Fuxing Road, Haidian 
      District, Beijing, 100853, China. xubn301@aliyun.com.
LA  - eng
GR  - 818QN321/Hainan Provincial Department of Science and Technology (CN)/
PT  - Journal Article
DEP - 20190629
PL  - Germany
TA  - Neurosurg Rev
JT  - Neurosurgical review
JID - 7908181
RN  - 0LVT1QZ0BA (Homocysteine)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Asian People
MH  - Case-Control Studies
MH  - China/epidemiology
MH  - Confidence Intervals
MH  - Female
MH  - Homocysteine/blood
MH  - Humans
MH  - Hyperhomocysteinemia/*complications/*epidemiology
MH  - Intracranial Aneurysm/*complications/*epidemiology
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Regression Analysis
MH  - Retrospective Studies
MH  - Risk Factors
OTO - NOTNLM
OT  - Case-control study
OT  - Homocysteine
OT  - Homocysteinemia
OT  - Intracranial aneurysms
OT  - Risk factors
EDAT- 2019/07/01 06:00
MHDA- 2020/11/27 06:00
CRDT- 2019/07/01 06:00
PHST- 2019/03/18 00:00 [received]
PHST- 2019/06/19 00:00 [accepted]
PHST- 2019/06/03 00:00 [revised]
PHST- 2019/07/01 06:00 [pubmed]
PHST- 2020/11/27 06:00 [medline]
PHST- 2019/07/01 06:00 [entrez]
AID - 10.1007/s10143-019-01138-9 [pii]
AID - 10.1007/s10143-019-01138-9 [doi]
PST - ppublish
SO  - Neurosurg Rev. 2020 Aug;43(4):1127-1134. doi: 10.1007/s10143-019-01138-9. Epub 
      2019 Jun 29.