PMID- 31256352
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1869-6953 (Print)
IS  - 1869-6961 (Electronic)
IS  - 1869-6961 (Linking)
VI  - 10
IP  - 4
DP  - 2019 Aug
TI  - Short-Term Versus Long-Term Adverse Cardiovascular Outcomes Post Percutaneous 
      Coronary Intervention in Patients with Insulin-Treated Type 2 Diabetes Mellitus: 
      A Simple Meta-Analysis.
PG  - 1487-1497
LID - 10.1007/s13300-019-0656-9 [doi]
AB  - INTRODUCTION: Type 2 diabetes mellitus (T2DM) is a major health issue, especially 
      in patients with coexisting coronary artery disease (CAD). Patients with 
      insulin-treated T2DM (ITDM) have worse outcomes than those with 
      non-insulin-treated T2DM. Very few studies have compared short-term to long-term 
      adverse cardiovascular outcomes following percutaneous coronary intervention 
      (PCI) in patients on insulin therapy. Therefore, in this meta-analysis, we 
      systematically compared short-term to long-term adverse cardiovascular outcomes 
      in a population of patients with ITDM following PCI. METHODS: We searched for 
      English-language publications focusing on PCI in patients with ITDM using 
      specific search terms/phrases. All the participants accepted for inclusion in 
      this meta-analysis were treated with a drug-eluting stent. Post-intervention 
      adverse cardiovascular outcomes observed during short-term and long-term 
      follow-up periods were assessed and compared. Statistical analysis was carried 
      out using the popular RevMan 5.3 software. Odd ratios (OR) with 95% confidence 
      intervals (CI) were calculated. RESULTS: Six studies comprising 1568 participants 
      with ITDM in total were included in this simple meta-analysis. Patient enrollment 
      periods varied but enrollment occurred during the years 1993-2012. When a 
      fixed-effects statistical model was used, post-PCI adverse cardiovascular 
      outcomes-such as major adverse cardiac events (MACEs) (OR 3.33, 95% CI 2.64-4.21; 
      P = 0.00001), all-cause mortality (OR 5.73, 95% CI 3.37-9.73; P = 0.00001), 
      myocardial infarction (MI) (OR 1.47, 95% CI 1.05-2.07; P = 0.02), and repeated 
      revascularization (OR 4.78, 95% CI 3.29-6.94; P = 0.00001)-were found to be 
      significantly more likely during the long-term follow-up period. A similar result 
      was observed with a random-effects statistical model. CONCLUSION: Adverse 
      cardiovascular outcomes post PCI were significantly more likely during the 
      long-term follow-up period than during the short-term follow-up period in these 
      patients with T2DM on insulin therapy. This hypothesis requires confirmation via 
      new comparative trials that consider short-term and long-term follow-up periods.
FAU - Lu, Hongtao
AU  - Lu H
AD  - Department of Cardiology, Jingzhou Central Hospital, The Second Clinical Medical 
      College, Yangtze University, Jingzhou, Hubei, People's Republic of China.
FAU - Tang, Bing
AU  - Tang B
AD  - Department of Cardiology, Jingzhou Central Hospital, The Second Clinical Medical 
      College, Yangtze University, Jingzhou, Hubei, People's Republic of China.
FAU - Zhou, Yanhua
AU  - Zhou Y
AD  - Department of Hematology, Jingzhou First People's Hospital, The First Affiliated 
      Hospital of Yangtze University, Jingzhou, Hubei, People's Republic of China.
FAU - Xu, Chenhong
AU  - Xu C
AD  - Department of Cardiology, Jingzhou Central Hospital, The Second Clinical Medical 
      College, Yangtze University, Jingzhou, Hubei, People's Republic of China.
FAU - Bundhun, Pravesh Kumar
AU  - Bundhun PK
AD  - Department of Internal Medicine, The First Affiliated Hospital of Guangxi Medical 
      University, Nanning, Guangxi, People's Republic of China.
FAU - Tang, Zhangui
AU  - Tang Z
AD  - Department of Cardiovascular Diseases, Xiangya Hospital, Central South 
      University, Changsha, Hunan, People's Republic of China.
FAU - Bao, Hong
AU  - Bao H
AD  - Jiangling County People's Hospital of Cardiology, Jingzhou, Hubei, People's 
      Republic of China. jzszxyyxnk@163.com.
LA  - eng
PT  - Journal Article
DEP - 20190629
PL  - United States
TA  - Diabetes Ther
JT  - Diabetes therapy : research, treatment and education of diabetes and related 
      disorders
JID - 101539025
PMC - PMC6612339
OTO - NOTNLM
OT  - Drug-eluting stents
OT  - Insulin therapy
OT  - Long-term cardiovascular outcomes
OT  - Major adverse cardiac events
OT  - Percutaneous coronary intervention
OT  - Short-term cardiovascular outcomes
OT  - Type 2 diabetes mellitus
EDAT- 2019/07/01 06:00
MHDA- 2019/07/01 06:01
PMCR- 2019/06/29
CRDT- 2019/07/01 06:00
PHST- 2019/05/23 00:00 [received]
PHST- 2019/07/01 06:00 [pubmed]
PHST- 2019/07/01 06:01 [medline]
PHST- 2019/07/01 06:00 [entrez]
PHST- 2019/06/29 00:00 [pmc-release]
AID - 10.1007/s13300-019-0656-9 [pii]
AID - 656 [pii]
AID - 10.1007/s13300-019-0656-9 [doi]
PST - ppublish
SO  - Diabetes Ther. 2019 Aug;10(4):1487-1497. doi: 10.1007/s13300-019-0656-9. Epub 
      2019 Jun 29.