PMID- 31256928
OWN - NLM
STAT- MEDLINE
DCOM- 20200722
LR  - 20200722
IS  - 1876-4738 (Electronic)
IS  - 0914-5087 (Linking)
VI  - 74
IP  - 6
DP  - 2019 Dec
TI  - Impact of transcatheter aortic valve replacement on hemodynamic status in 
      patients with aortic stenosis and mitral stenosis: Doppler echocardiographic 
      study.
PG  - 532-538
LID - S0914-5087(19)30149-2 [pii]
LID - 10.1016/j.jjcc.2019.05.010 [doi]
AB  - BACKGROUND: Mitral stenosis (MS) is often concomitant with aortic stenosis (AS). 
      However, little is known about the functional status following transcatheter 
      aortic valve replacement (TAVR) alone in patients with severe AS and MS and the 
      impact of TAVR for AS on MS hemodynamics. METHODS: We enrolled 11 patients (age 
      83.6+/-4.7 years, eight women) with severe AS and MS who underwent TAVR. We 
      compared New York Heart Association (NYHA) functional class and mean transmitral 
      pressure gradient (MPG), mitral valve area (MVA), and stroke volume (SV) measured 
      by transthoracic Doppler echocardiography between baseline and after TAVR. We 
      also examined the calcification of the mitral annulus and mitral leaflet opening. 
      RESULTS: NYHA functional class improved after TAVR in all 11 patients. As SV 
      increased after TAVR (52+/-12mL to 63+/-18mL, p=0.041), MPG decreased and MVA 
      increased (6.9+/-3.8mmHg to 5.1+/-2.5mmHg, p=0.011 for MPG and 1.12+/-0.25cm(2) to 
      1.49+/-0.43cm(2), p=0.035 for MVA). However, MPG increased in one patient in whom 
      calcification extended into the entire anterior mitral leaflet (AML) and AML 
      mobility was severely reduced. CONCLUSIONS: NYHA functional class and hemodynamic 
      status of MS improved after TAVR in patients with severe AS and MS. TAVR might 
      provide therapeutic efficacy for selected symptomatic severe AS patients with MS.
CI  - Copyright (c) 2019 Japanese College of Cardiology. Published by Elsevier Ltd. All 
      rights reserved.
FAU - Kato, Nahoko
AU  - Kato N
AD  - Tokyo Bay Urayasu-Ichikawa Medical Center, Department of Cardiology, Urayasu, 
      Japan; Mayo Clinic, Department of Cardiovascular Medicine, Rochester, MN, USA; 
      Tokyo Medical Dental University, Department of Cardiovascular Medicine, Tokyo, 
      Japan.
FAU - Shibayama, Kentaro
AU  - Shibayama K
AD  - Tokyo Bay Urayasu-Ichikawa Medical Center, Department of Cardiology, Urayasu, 
      Japan. Electronic address: shibao_k@hotmail.com.
FAU - Omori, Nami
AU  - Omori N
AD  - Tokyo Bay Urayasu-Ichikawa Medical Center, Department of Cardiology, Urayasu, 
      Japan.
FAU - Hoshina, Mizuho
AU  - Hoshina M
AD  - Tokyo Bay Urayasu-Ichikawa Medical Center, Department of Cardiology, Urayasu, 
      Japan.
FAU - Makihara, Yu
AU  - Makihara Y
AD  - Tokyo Bay Urayasu-Ichikawa Medical Center, Department of Cardiology, Urayasu, 
      Japan.
FAU - Okumura, Hiroshi
AU  - Okumura H
AD  - Tokyo Bay Urayasu-Ichikawa Medical Center, Department of Cardiology, Urayasu, 
      Japan.
FAU - Tabata, Minoru
AU  - Tabata M
AD  - Tokyo Bay Urayasu-Ichikawa Medical Center, Department of Cardiovascular Surgeon, 
      Urayasu, Japan.
FAU - Obunai, Kotaro
AU  - Obunai K
AD  - Tokyo Bay Urayasu-Ichikawa Medical Center, Department of Cardiology, Urayasu, 
      Japan.
FAU - Hirao, Kenzo
AU  - Hirao K
AD  - Tokyo Medical Dental University, Department of Cardiovascular Medicine, Tokyo, 
      Japan.
FAU - Pellikka, Patricia A
AU  - Pellikka PA
AD  - Mayo Clinic, Department of Cardiovascular Medicine, Rochester, MN, USA.
FAU - Watanabe, Hiroyuki
AU  - Watanabe H
AD  - Tokyo Bay Urayasu-Ichikawa Medical Center, Department of Cardiology, Urayasu, 
      Japan.
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20190627
PL  - Netherlands
TA  - J Cardiol
JT  - Journal of cardiology
JID - 8804703
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Aortic Valve/diagnostic imaging/physiopathology/surgery
MH  - Aortic Valve Stenosis/*diagnostic imaging/physiopathology/surgery
MH  - Calcinosis/diagnostic imaging/etiology
MH  - *Echocardiography, Doppler
MH  - Female
MH  - Hemodynamics/*physiology
MH  - Humans
MH  - Male
MH  - Mitral Valve/diagnostic imaging/physiopathology
MH  - Mitral Valve Stenosis/*diagnostic imaging/physiopathology/surgery
MH  - Postoperative Period
MH  - Stroke Volume
MH  - Transcatheter Aortic Valve Replacement/*methods
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Aortic stenosis
OT  - Echocardiography
OT  - Mitral stenosis
OT  - Transcatheter aortic valve replacement
EDAT- 2019/07/02 06:00
MHDA- 2020/07/23 06:00
CRDT- 2019/07/02 06:00
PHST- 2019/01/15 00:00 [received]
PHST- 2019/05/02 00:00 [revised]
PHST- 2019/05/23 00:00 [accepted]
PHST- 2019/07/02 06:00 [pubmed]
PHST- 2020/07/23 06:00 [medline]
PHST- 2019/07/02 06:00 [entrez]
AID - S0914-5087(19)30149-2 [pii]
AID - 10.1016/j.jjcc.2019.05.010 [doi]
PST - ppublish
SO  - J Cardiol. 2019 Dec;74(6):532-538. doi: 10.1016/j.jjcc.2019.05.010. Epub 2019 Jun 
      27.