PMID- 31257246
OWN - NLM
STAT- MEDLINE
DCOM- 20200414
LR  - 20200414
IS  - 1884-2836 (Electronic)
IS  - 1344-6304 (Linking)
VI  - 72
IP  - 6
DP  - 2019 Nov 21
TI  - Human Leukocyte Antigen-Associated HIV-1 CRF02_AG gag and vif Polymorphisms in 
      Ghana.
PG  - 374-380
LID - 10.7883/yoken.JJID.2019.201 [doi]
AB  - In human immunodeficiency virus type-1 (HIV-1) infections, cytotoxic T-lymphocyte 
      (CTL) responses targeting human leukocyte antigen (HLA)-restricted viral epitopes 
      exert strong suppressive pressure on viral replication and frequently select for 
      mutations resulting in viral escape from CTL recognition. Numerous data on these 
      HLA-associated mutations in HIV-1 subtypes B and C have been amassed with few 
      reports described in other subtypes. In the present study, we investigated the 
      HLA-associated mutations in HIV-1 subtype CRF02_AG prevailing in Ghana, Western 
      Africa. We determined viral gag sequences in 246 out of 324 HIV-1-infected 
      Ghanaians. Phylogeny analysis revealed that 200 (81.3%) individuals were infected 
      with HIV-1 CRF02_AG. Full gag and vif sequences were obtained from 199 and 138, 
      respectively, out of the 200 individuals infected with CRF02_AG and subjected to 
      determination of HLA-associated mutations. The analysis found HLA-associated 
      HIV-1 CRF02_AG non-synonymous polymorphisms at 19 sites; 13 in gag and six in 
      vif, including those that were newly determined. Generation of this data is an 
      important contribution to our understanding of HIV-1 CRF02_AG and host T cell 
      interaction.
FAU - Adusei-Poku, Mildred A
AU  - Adusei-Poku MA
AD  - Joint Research Center for Human Retrovirus Infection, Kumamoto University.
AD  - AIDS Research Center, National Institute of Infectious Diseases.
FAU - Matsuoka, Saori
AU  - Matsuoka S
AD  - AIDS Research Center, National Institute of Infectious Diseases.
FAU - Bonney, Evelyn Y
AU  - Bonney EY
AD  - Noguchi Memorial Institute for Medical Research (NMIMR), University of Ghana.
FAU - Abana, Christopher Z
AU  - Abana CZ
AD  - Noguchi Memorial Institute for Medical Research (NMIMR), University of Ghana.
FAU - Duker, Ewurabena O
AU  - Duker EO
AD  - Noguchi Memorial Institute for Medical Research (NMIMR), University of Ghana.
FAU - Nii-Trebi, Nicholas I
AU  - Nii-Trebi NI
AD  - School of Biomedical and Allied Health, College of Health Sciences, University of 
      Ghana.
FAU - Ofori, Sampson B
AU  - Ofori SB
AD  - Koforidua Regional Hospital, Koforidua, Eastern Region.
FAU - Mizutani, Taketoshi
AU  - Mizutani T
AD  - Institute of Medical Science, University of Tokyo.
FAU - Ishizaka, Aya
AU  - Ishizaka A
AD  - Institute of Medical Science, University of Tokyo.
FAU - Shiino, Teiichiro
AU  - Shiino T
AD  - AIDS Research Center, National Institute of Infectious Diseases.
FAU - Kawana-Tachikawa, Ai
AU  - Kawana-Tachikawa A
AD  - Joint Research Center for Human Retrovirus Infection, Kumamoto University.
AD  - AIDS Research Center, National Institute of Infectious Diseases.
AD  - Institute of Medical Science, University of Tokyo.
FAU - Ishikawa, Koichi
AU  - Ishikawa K
AD  - AIDS Research Center, National Institute of Infectious Diseases.
FAU - Ampofo, William K
AU  - Ampofo WK
AD  - Noguchi Memorial Institute for Medical Research (NMIMR), University of Ghana.
FAU - Matano, Tetsuro
AU  - Matano T
AD  - Joint Research Center for Human Retrovirus Infection, Kumamoto University.
AD  - AIDS Research Center, National Institute of Infectious Diseases.
AD  - Institute of Medical Science, University of Tokyo.
LA  - eng
PT  - Journal Article
DEP - 20190628
PL  - Japan
TA  - Jpn J Infect Dis
JT  - Japanese journal of infectious diseases
JID - 100893704
RN  - 0 (HLA Antigens)
RN  - 0 (gag Gene Products, Human Immunodeficiency Virus)
RN  - 0 (vif Gene Products, Human Immunodeficiency Virus)
RN  - 0 (vif protein, Human immunodeficiency virus 1)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Child
MH  - Female
MH  - Genotype
MH  - Ghana/epidemiology
MH  - HIV Infections/epidemiology/*virology
MH  - HIV-1/*genetics
MH  - HLA Antigens/*immunology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Phylogeny
MH  - *Polymorphism, Genetic
MH  - Young Adult
MH  - gag Gene Products, Human Immunodeficiency Virus/*genetics
MH  - vif Gene Products, Human Immunodeficiency Virus/*genetics
OTO - NOTNLM
OT  - CRF02_AG
OT  - Ghana
OT  - HIV-1
OT  - HLA-associated polymorphism
EDAT- 2019/07/02 06:00
MHDA- 2020/04/15 06:00
CRDT- 2019/07/02 06:00
PHST- 2019/07/02 06:00 [pubmed]
PHST- 2020/04/15 06:00 [medline]
PHST- 2019/07/02 06:00 [entrez]
AID - 10.7883/yoken.JJID.2019.201 [doi]
PST - ppublish
SO  - Jpn J Infect Dis. 2019 Nov 21;72(6):374-380. doi: 10.7883/yoken.JJID.2019.201. 
      Epub 2019 Jun 28.