PMID- 31258422
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1524-5012 (Print)
IS  - 1524-5012 (Linking)
VI  - 19
IP  - 2
DP  - 2019 Summer
TI  - Metaanalysis of Multivessel vs Culprit Artery Only Percutaneous Coronary 
      Intervention in ST Elevation Myocardial Infarction.
PG  - 107-115
LID - 10.31486/toj.18.0033 [doi]
AB  - Background: Primary percutaneous coronary intervention (PCI) is the most 
      frequently used treatment modality for patients presenting with ST elevation 
      myocardial infarction (STEMI). Current professional society guidelines recommend 
      culprit artery only PCI. Recent evidence suggests the potential benefit of 
      multivessel PCI among patients with STEMI that is not complicated by cardiogenic 
      shock. Methods: We systematically searched PubMed, EMBASE, and the Cochrane 
      Central Register of Controlled Trials for clinical studies of patients with 
      STEMI, not complicated by cardiogenic shock, who underwent primary PCI between 
      January 1966 and January 2018. We evaluated all-cause and cardiovascular 
      mortality, reinfarction, and repeat revascularization among patients randomized 
      to a multivessel PCI strategy compared to a culprit artery only PCI strategy. 
      Results: Four randomized clinical trials with a total of 1,044 patients met the 
      inclusion criteria. Five hundred and sixty-six patients underwent multivessel 
      PCI, and 478 patients underwent culprit artery only PCI. Multivessel PCI reduced 
      all the studied endpoints: total death, cardiac death, reinfarction, and repeat 
      revascularization (all P values <0.05). Conclusion: To our knowledge, this is the 
      largest metaanalysis of randomized controlled trials studying multivessel PCI vs 
      culprit artery only PCI in STEMI patients without shock, among whom lesion 
      severity was graded by angiography alone. We found that compared to culprit 
      artery only PCI, the multivessel PCI strategy was beneficial in reducing 
      all-cause and cardiovascular mortality, reinfarction, and the need for repeat 
      revascularization.
FAU - Garcia, Daniel C
AU  - Garcia DC
AD  - Department of Cardiology, Ochsner Clinic Foundation, New Orleans, LA.
FAU - Benjo, Alexandre M
AU  - Benjo AM
AD  - Department of Cardiology, Ochsner Clinic Foundation, New Orleans, LA.
FAU - White, Christopher J
AU  - White CJ
AD  - Department of Cardiology, Ochsner Clinic Foundation, New Orleans, LA.
AD  - The University of Queensland Faculty of Medicine, Ochsner Clinical School, New 
      Orleans, LA.
FAU - Cardoso, Rhanderson N
AU  - Cardoso RN
AD  - Department of Internal Medicine, University of Miami/Jackson Memorial Hospital, 
      Miami, FL.
FAU - Macedo, Francisco Y B
AU  - Macedo FYB
AD  - Department of Cardiology, Baylor College of Medicine, Houston, TX.
FAU - Schob, Alan H
AU  - Schob AH
AD  - Department of Cardiology, Department of Internal Medicine, The Miami VA Hospital, 
      Miami, FL.
FAU - El-Hayek, Georges E
AU  - El-Hayek GE
AD  - Department of Internal Medicine, St. Luke's-Roosevelt Hospital Center, New York, 
      NY.
FAU - Nadkarni, Girish N
AU  - Nadkarni GN
AD  - Department of Internal Medicine, Mount Sinai Hospital, New York, NY.
FAU - Aziz, Emad F
AU  - Aziz EF
AD  - Department of Internal Medicine, St. Luke's-Roosevelt Hospital Center, New York, 
      NY.
FAU - Patel, Rajan A G
AU  - Patel RAG
AD  - Department of Cardiology, Ochsner Clinic Foundation, New Orleans, LA.
AD  - The University of Queensland Faculty of Medicine, Ochsner Clinical School, New 
      Orleans, LA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ochsner J
JT  - Ochsner journal
JID - 101125795
PMC - PMC6584205
OTO - NOTNLM
OT  - Coronary artery disease
OT  - ST elevation myocardial infarction
OT  - mortality
OT  - myocardial revascularization
OT  - percutaneous coronary intervention
EDAT- 2019/07/02 06:00
MHDA- 2019/07/02 06:01
PMCR- 2019/06/01
CRDT- 2019/07/02 06:00
PHST- 2019/07/02 06:00 [entrez]
PHST- 2019/07/02 06:00 [pubmed]
PHST- 2019/07/02 06:01 [medline]
PHST- 2019/06/01 00:00 [pmc-release]
AID - toj.18.0033 [pii]
AID - 10.31486/toj.18.0033 [doi]
PST - ppublish
SO  - Ochsner J. 2019 Summer;19(2):107-115. doi: 10.31486/toj.18.0033.