PMID- 31258710
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1792-0981 (Print)
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Linking)
VI  - 18
IP  - 1
DP  - 2019 Jul
TI  - Long-term prognostic value of coronary computed tomography angiography for 
      asymptomatic patients with CAD in type 2 diabetes mellitus.
PG  - 747-754
LID - 10.3892/etm.2019.7593 [doi]
AB  - The present study was performed to investigate the prognostic value of coronary 
      computed tomography angiography (CTA) results for asymptomatic patients with 
      coronary artery disease (CAD) in type 2 diabetes mellitus (T2DM). A total of 164 
      asymptomatic patients with T2DM were enrolled at Weifang Traditional Chinese 
      Hospital (Weifang, China). Coronary plaques and stenosis severity were evaluated 
      after CTA. Structures >1 mm(2) adjacent to or within the coronary artery lumen 
      that could be clearly separated from the vessel lumen, was scored as a coronary 
      plaque. Stenosis of >/=50% was considered as being obstructive. CAD was defined as 
      the presence of any coronary plaque or a coronary artery calcium (CAC) score of 
      >0. A CAC score of 0 and no coronary plaques was considered to indicate the 
      absence of CAD. A 5-year follow-up was performed to determine the impact of the 
      CTA findings and various clinicopathological characteristics on the prognosis of 
      all participants. The primary end-point was any cardiac event. Event-free 
      survival curves were plotted using the Kaplan-Meier method and compared using the 
      log-rank test. Based on the coronary CTA results, the patients were classified 
      into 3 groups according to the extent of stenosis: Normal coronary arteries, 
      obstructive CAD and non-obstructive CAD. Significant differences in 5-year 
      event-free survival were identified among the groups with normal coronary 
      arteries, non-obstructive CAD and obstructive CAD (P=0.026). Further analysis 
      indicated that the event-free survival rate of patients with 1-vessel CAD was 
      94.11%, that of patients with 2-vessel CAD was 73.68% and that associated with 
      3-vessel CAD was 61.54%. Multivariate Cox regression analysis revealed that 
      non-obstructive as well as obstructive CAD diagnosed by coronary CTA are 
      prognostic indicators for asymptomatic T2DM patients [hazard ratio (HR)=11.132, 
      95% confidence interval (CI): 1.857-66.742, P=0.008; HR=7.792, 95% CI: 
      1.750-34.698, P=0.007, respectively]. In conclusion, the present study suggests 
      that coronary CTA may predict the prognosis of asymptomatic patients with T2DM.
FAU - Tian, Peigang
AU  - Tian P
AD  - Imaging Center, Weifang Traditional Chinese Hospital, Weifang, Shandong 261000, 
      P.R. China.
FAU - Zheng, Xiangyang
AU  - Zheng X
AD  - Imaging Center, Weifang Traditional Chinese Hospital, Weifang, Shandong 261000, 
      P.R. China.
FAU - Li, Mingzhi
AU  - Li M
AD  - Imaging Center, Weifang Traditional Chinese Hospital, Weifang, Shandong 261000, 
      P.R. China.
FAU - Li, Weiwei
AU  - Li W
AD  - Department of Radiology, Tai'an Central Hospital Branch, Tai'an, Shandong 271000, 
      P.R. China.
FAU - Niu, Qingliang
AU  - Niu Q
AD  - Imaging Center, Weifang Traditional Chinese Hospital, Weifang, Shandong 261000, 
      P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20190520
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC6566055
OTO - NOTNLM
OT  - coronary artery disease
OT  - coronary computed tomography angiography
OT  - prognosis
OT  - type 2 diabetes mellitus
EDAT- 2019/07/02 06:00
MHDA- 2019/07/02 06:01
PMCR- 2019/05/20
CRDT- 2019/07/02 06:00
PHST- 2018/06/16 00:00 [received]
PHST- 2019/01/18 00:00 [accepted]
PHST- 2019/07/02 06:00 [entrez]
PHST- 2019/07/02 06:00 [pubmed]
PHST- 2019/07/02 06:01 [medline]
PHST- 2019/05/20 00:00 [pmc-release]
AID - ETM-0-0-7593 [pii]
AID - 10.3892/etm.2019.7593 [doi]
PST - ppublish
SO  - Exp Ther Med. 2019 Jul;18(1):747-754. doi: 10.3892/etm.2019.7593. Epub 2019 May 
      20.