PMID- 31259747
OWN - NLM
STAT- MEDLINE
DCOM- 20200730
LR  - 20200730
IS  - 1473-6322 (Electronic)
IS  - 1473-6322 (Linking)
VI  - 19
IP  - 5
DP  - 2019 Oct
TI  - Mastocytosis presenting as insect anaphylaxis: gender differences and natural 
      history.
PG  - 468-474
LID - 10.1097/ACI.0000000000000567 [doi]
AB  - PURPOSE OF REVIEW: Currently, there is strong evidence about an association 
      between hymenoptera venom anaphylaxis (HVA) and mastocytosis. This review is 
      focused on the most relevant clinical and biological features of systemic 
      mastocytosis associated with HVA. RECENT FINDINGS: HVA is a relatively common 
      complication that modifies the natural course of patients with mastocytosis, 
      particularly men with indolent systemic mastocytosis without skin lesions (ISMs-) 
      in whom HVA can be the presenting symptom in up to around one-half of the cases. 
      Patients with ISMs- associated with HVA are typically males with cardiovascular 
      symptoms in the absence of itching, urticaria, and angioedema during anaphylaxis. 
      Noteworthy, ISMs- is characterized by a low bone marrow mast cell load and a low 
      risk for disease progression. Early and more recent studies support that specific 
      venom immunotherapy (VIT) is a well-tolerated and effective treatment in patients 
      with mastocytosis. SUMMARY: VIT should be given life-long to all patients with 
      mastocytosis and proven immunoglobulin E (IgE)-mediated HVA. In patients with 
      negative venom skin test and undetectable IgE antibodies, additional studies such 
      as component-based allergy testing might contribute to confirm an IgE-mediated 
      mechanism of anaphylaxis in some cases, thus providing the indication of VIT.
FAU - Alvarez-Twose, Ivan
AU  - Alvarez-Twose I
AD  - Instituto de Estudios de Mastocitosis de Castilla La Mancha (CLMast), Hospital 
      Virgen del Valle, Complejo Hospitalario de Toledo.
AD  - Spanish Network on Mastocytosis (REMA), Toledo, Spain.
FAU - Matito, Almudena
AU  - Matito A
AD  - Instituto de Estudios de Mastocitosis de Castilla La Mancha (CLMast), Hospital 
      Virgen del Valle, Complejo Hospitalario de Toledo.
AD  - Spanish Network on Mastocytosis (REMA), Toledo, Spain.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Curr Opin Allergy Clin Immunol
JT  - Current opinion in allergy and clinical immunology
JID - 100936359
RN  - 0 (Arthropod Venoms)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - *Anaphylaxis/blood/immunology/therapy
MH  - Animals
MH  - Arthropod Venoms/*toxicity
MH  - *Desensitization, Immunologic
MH  - Female
MH  - Humans
MH  - *Hymenoptera
MH  - Immunoglobulin E/blood/immunology
MH  - Male
MH  - *Mastocytosis/blood/immunology/therapy
MH  - *Sex Characteristics
EDAT- 2019/07/02 06:00
MHDA- 2020/07/31 06:00
CRDT- 2019/07/02 06:00
PHST- 2019/07/02 06:00 [pubmed]
PHST- 2020/07/31 06:00 [medline]
PHST- 2019/07/02 06:00 [entrez]
AID - 10.1097/ACI.0000000000000567 [doi]
PST - ppublish
SO  - Curr Opin Allergy Clin Immunol. 2019 Oct;19(5):468-474. doi: 
      10.1097/ACI.0000000000000567.