PMID- 31260706
OWN - NLM
STAT- MEDLINE
DCOM- 20200717
LR  - 20200717
IS  - 1872-7492 (Electronic)
IS  - 0168-1702 (Linking)
VI  - 270
DP  - 2019 Sep
TI  - Characterization of porcine tripartite motif genes as host restriction factors 
      against PRRSV and PEDV infection.
PG  - 197647
LID - S0168-1702(19)30279-5 [pii]
LID - 10.1016/j.virusres.2019.197647 [doi]
AB  - Members of the tripartite motif (TRIM) family are the important effectors of the 
      innate immune response against viral infections. However, it is still unknown 
      whether porcine TRIM (pTRIM) genes may restrict the infection of porcine 
      reproductive and respiratory syndrome virus (PRRSV) and porcine epidemic diarrhea 
      virus (PEDV). In this study, we firstly defined the entire pTRIM family. 
      Fifty-seven pTRIMs were classified into 12 sub-families (C-I to C-XII) based on 
      variable C-terminus, and 17 out of them were identified as positively selected 
      genes. Nine pTRIMs were identified as the IFN-stimulated genes in IFN-beta treated 
      porcine alveolar macrophages (PAMs). Twelve pTRIMs were regulated in PRRSV or 
      PEDV-infected PAMs, respectively. The mRNA expression of the implicated 
      restriction factors (pTRIM5, 14, 21, 25 and 38) was detectable in all swine 
      tissues studied, with the high expression in the spleen and lung tissues. These 
      results firstly present the comprehensive characterization of pTRIM genes, and 
      suggest the pTRIM5, 14, 21, 25, and 38 genes as the implicated host restriction 
      factors against PRRSV and PEDV infection, which provide a basis to further study 
      the functions of pTRIMs and the mechanism by which pTRIMs may act during viral 
      infection.
CI  - Copyright (c) 2019. Published by Elsevier B.V.
FAU - Wei, Ying
AU  - Wei Y
AD  - State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen 
      University, Guangzhou 510006, China.
FAU - Zou, Chuangchao
AU  - Zou C
AD  - State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen 
      University, Guangzhou 510006, China.
FAU - Zeng, Siying
AU  - Zeng S
AD  - State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen 
      University, Guangzhou 510006, China.
FAU - Xue, Chunyi
AU  - Xue C
AD  - State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen 
      University, Guangzhou 510006, China. Electronic address: xuechy@mail.sysu.edu.cn.
FAU - Cao, Yongchang
AU  - Cao Y
AD  - State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen 
      University, Guangzhou 510006, China. Electronic address: caoych@mail.sysu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190628
PL  - Netherlands
TA  - Virus Res
JT  - Virus research
JID - 8410979
RN  - 0 (Tripartite Motif Proteins)
RN  - 77238-31-4 (Interferon-beta)
SB  - IM
MH  - Animals
MH  - Coronavirus Infections/*genetics/immunology
MH  - Evolution, Molecular
MH  - *Host Microbial Interactions
MH  - Immunity, Innate
MH  - Interferon-beta/pharmacology
MH  - Lung/virology
MH  - Macrophages, Alveolar/drug effects/immunology/virology
MH  - Porcine Reproductive and Respiratory Syndrome/*genetics/immunology
MH  - Porcine epidemic diarrhea virus
MH  - Porcine respiratory and reproductive syndrome virus
MH  - Swine/genetics/immunology
MH  - Swine Diseases/immunology/virology
MH  - Tripartite Motif Proteins/*genetics/immunology
OTO - NOTNLM
OT  - IFN-beta
OT  - Porcine epidemic diarrhea virus
OT  - Porcine reproductive and respiratory syndrome virus
OT  - Porcine tripartite motif family
OT  - Positive selection
EDAT- 2019/07/02 06:00
MHDA- 2020/07/18 06:00
CRDT- 2019/07/02 06:00
PHST- 2019/04/26 00:00 [received]
PHST- 2019/06/26 00:00 [revised]
PHST- 2019/06/27 00:00 [accepted]
PHST- 2019/07/02 06:00 [pubmed]
PHST- 2020/07/18 06:00 [medline]
PHST- 2019/07/02 06:00 [entrez]
AID - S0168-1702(19)30279-5 [pii]
AID - 10.1016/j.virusres.2019.197647 [doi]
PST - ppublish
SO  - Virus Res. 2019 Sep;270:197647. doi: 10.1016/j.virusres.2019.197647. Epub 2019 
      Jun 28.