PMID- 31262432
OWN - NLM
STAT- MEDLINE
DCOM- 20200917
LR  - 20200917
IS  - 1873-2402 (Electronic)
IS  - 0006-3223 (Linking)
VI  - 86
IP  - 8
DP  - 2019 Oct 15
TI  - Joint Attention in Infancy and the Emergence of Autism.
PG  - 631-638
LID - S0006-3223(19)31372-1 [pii]
LID - 10.1016/j.biopsych.2019.05.006 [doi]
AB  - BACKGROUND: In typical infant development, parents and their children jointly 
      contribute to establishing frequent episodes of joint attention that boost 
      language acquisition and shape social cognition. Here we used novel live 
      eye-tracking technology to evaluate the degree to which autism spectrum disorder 
      (ASD) is related to reduced responding to others' joint attention bids in infancy 
      (RJA) and to a reduced tendency to initiate joint attention episodes (IJA). 
      Because young infants use their gaze for both RJA and IJA, this approach allowed 
      us to quantify these elusive processes early in life. METHODS: The final sample 
      consisted of 112 infants (54 boys and 58 girls), of whom 81 were at familial risk 
      for ASD and 31 were typically developing low-risk infants. At follow-up (36 
      months of age), 22 children in the high-risk group were diagnosed with ASD. 
      RESULTS: At 10 months of age, rates of IJA were lower in infants later diagnosed 
      with ASD than in the comparison groups (effect sizes d = 0.78-0.95) and followed 
      an atypical developmental trajectory from 10 to 18 months (p < .002). RJA 
      distinguished infants based on familial ASD risk, albeit not ASD diagnosis. The 
      differences in IJA could not be explained by overall looking time, social 
      preference, eye movement latencies, or number of fixations. CONCLUSIONS: This 
      live eye-tracking study suggests that during an important period for the 
      development of social cognition (10-18 months of age), infants later diagnosed 
      with ASD show marked atypicalities in IJA but not in RJA. The results indicate 
      that IJA is an important target for future prodromal intervention trials.
CI  - Copyright (c) 2019 Society of Biological Psychiatry. Published by Elsevier Inc. All 
      rights reserved.
FAU - Nystrom, Par
AU  - Nystrom P
AD  - Uppsala Child & BabyLab, Department of Psychology, Uppsala University, Uppsala, 
      Sweden.
FAU - Thorup, Emilia
AU  - Thorup E
AD  - Uppsala Child & BabyLab, Department of Psychology, Uppsala University, Uppsala, 
      Sweden; Department of Psychology, Lund University, Lund, Sweden.
FAU - Bolte, Sven
AU  - Bolte S
AD  - Center of Neurodevelopmental Disorders at Karolinska Institutet, Neuropsychiatry 
      Division, Department of Women's and Children's Health, Karolinska Institutet, 
      Stockholm, Sweden; Child and Adolescent Psychiatry, Center for Psychiatry 
      Research, Stockholm County Council, Stockholm, Sweden.
FAU - Falck-Ytter, Terje
AU  - Falck-Ytter T
AD  - Uppsala Child & BabyLab, Department of Psychology, Uppsala University, Uppsala, 
      Sweden; Swedish Collegium for Advanced Study, Uppsala, Sweden; Center of 
      Neurodevelopmental Disorders at Karolinska Institutet, Neuropsychiatry Division, 
      Department of Women's and Children's Health, Karolinska Institutet, Stockholm, 
      Sweden; Child and Adolescent Psychiatry, Center for Psychiatry Research, 
      Stockholm County Council, Stockholm, Sweden. Electronic address: 
      terje.falck-ytter@psyk.uu.se.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190515
PL  - United States
TA  - Biol Psychiatry
JT  - Biological psychiatry
JID - 0213264
SB  - IM
MH  - *Attention
MH  - Autism Spectrum Disorder/physiopathology/*psychology
MH  - Child Development
MH  - Child, Preschool
MH  - Eye Movement Measurements
MH  - Female
MH  - *Fixation, Ocular
MH  - Humans
MH  - Infant
MH  - Male
OTO - NOTNLM
OT  - Biomarker
OT  - Neurodevelopmental disorders
OT  - Parent-child interaction
OT  - Prodromal intervention
OT  - Reward processing
OT  - Social cognition
EDAT- 2019/07/03 06:00
MHDA- 2020/09/18 06:00
CRDT- 2019/07/03 06:00
PHST- 2018/11/08 00:00 [received]
PHST- 2019/05/03 00:00 [revised]
PHST- 2019/05/03 00:00 [accepted]
PHST- 2019/07/03 06:00 [pubmed]
PHST- 2020/09/18 06:00 [medline]
PHST- 2019/07/03 06:00 [entrez]
AID - S0006-3223(19)31372-1 [pii]
AID - 10.1016/j.biopsych.2019.05.006 [doi]
PST - ppublish
SO  - Biol Psychiatry. 2019 Oct 15;86(8):631-638. doi: 10.1016/j.biopsych.2019.05.006. 
      Epub 2019 May 15.