PMID- 31262970
OWN - NLM
STAT- MEDLINE
DCOM- 20200911
LR  - 20200911
IS  - 1573-4935 (Electronic)
IS  - 0144-8463 (Print)
IS  - 0144-8463 (Linking)
VI  - 39
IP  - 7
DP  - 2019 Jul 31
TI  - The pathogenic role of connective tissue growth factor in osteoarthritis.
LID - BSR20191374 [pii]
LID - 10.1042/BSR20191374 [doi]
AB  - Osteoarthritis (OA) is the most common form of arthritis, and connective tissue 
      growth factor (CTGF) is found to be up-regulated in adjacent areas of cartilage 
      surface damage. CTGF is present in osteophytes of late stage OA. In the present 
      study, we have reviewed association of CTGF in the development and progression of 
      OA and the potential effects of CTGF as a therapeutic agent for the treatment of 
      OA. We have reviewed the recent articles on CTGF and OA in databases like PubMed, 
      google scholar, and SCOPUS and collected the information for the articles. CTGF 
      is usually up-regulated in synovial fluid of OA that stimulates the production of 
      inflammatory cytokines. CTGF also activates nuclear factor-kappaB, increases the 
      production of chemokines and cytokines, and up-regulates matrix 
      metalloproteinases-3 (MMP-3) that in turn leads to the reduction in proteoglycan 
      contents in joint cartilage. Consequently, cartilage homeostasis is imbalanced 
      that might contribute to the pathogenesis of OA by developing synovial 
      inflammation and cartilage degradation. CTGF might serve as a useful biomarker 
      for the prognosis and treatment of OA, and recent studies have taken attempt to 
      use CTGF as therapeutic target of OA. However, more investigations with clinical 
      trials are necessary to validate the possibility of use of CTGF as a biomarker in 
      OA diagnosis and therapeutic target for OA treatment.
CI  - (c) 2019 The Author(s).
FAU - Tu, Min
AU  - Tu M
AD  - Department of Orthopedics, Second People's Hospital of Jingmen, Jingmen 448000, 
      China.
FAU - Yao, Yao
AU  - Yao Y
AD  - Department of Gastrointestinal Surgery, Second People's Hospital of Jingmen, 
      Jingmen 448000, China.
FAU - Qiao, Feng Hua
AU  - Qiao FH
AD  - Department of Gynecology, Second People's Hospital of Jingmen, Jingmen 448000, 
      China.
FAU - Wang, Li
AU  - Wang L
AUID- ORCID: 0000-0003-2438-6887
AD  - Department of Gynecology, First People's Hospital of Jingmen, Jingmen, HuBei 
      448000, China wang_li2000@hotmail.com 373730165@qq.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20190718
PL  - England
TA  - Biosci Rep
JT  - Bioscience reports
JID - 8102797
RN  - 0 (Biomarkers)
RN  - 0 (CCN2 protein, human)
RN  - 0 (NF-kappa B)
RN  - 139568-91-5 (Connective Tissue Growth Factor)
RN  - EC 3.4.24.17 (MMP3 protein, human)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Biomarkers/*blood
MH  - Cartilage, Articular/metabolism/pathology
MH  - Connective Tissue Growth Factor/blood/*genetics
MH  - Humans
MH  - Inflammation/blood/*genetics/pathology
MH  - Matrix Metalloproteinase 3/genetics
MH  - NF-kappa B/genetics
MH  - Osteoarthritis/blood/*genetics/pathology
MH  - Synovial Membrane/metabolism/pathology
PMC - PMC6639465
OTO - NOTNLM
OT  - Osteoarthritis
OT  - cartilage homeostasis
OT  - connective tissue growth factor
OT  - inflammatory mediators
COIS- The authors declare that there are no competing interests associated with the 
      manuscript.
EDAT- 2019/07/03 06:00
MHDA- 2020/09/12 06:00
PMCR- 2019/07/19
CRDT- 2019/07/03 06:00
PHST- 2019/05/07 00:00 [received]
PHST- 2019/06/24 00:00 [revised]
PHST- 2019/06/26 00:00 [accepted]
PHST- 2019/07/03 06:00 [pubmed]
PHST- 2020/09/12 06:00 [medline]
PHST- 2019/07/03 06:00 [entrez]
PHST- 2019/07/19 00:00 [pmc-release]
AID - BSR20191374 [pii]
AID - 10.1042/BSR20191374 [doi]
PST - epublish
SO  - Biosci Rep. 2019 Jul 18;39(7):BSR20191374. doi: 10.1042/BSR20191374. Print 2019 
      Jul 31.