PMID- 31263994
OWN - NLM
STAT- MEDLINE
DCOM- 20200601
LR  - 20200601
IS  - 1437-160X (Electronic)
IS  - 0172-8172 (Linking)
VI  - 39
IP  - 12
DP  - 2019 Dec
TI  - Study of familial aggregation of autoimmune rheumatic diseases in Asian Indian 
      patients with systemic lupus erythematosus.
PG  - 2053-2060
LID - 10.1007/s00296-019-04355-z [doi]
AB  - Systemic lupus erythematosus (SLE) and other autoimmune rheumatic diseases (AIRD) 
      tend to co-aggregate in families, making positive familial history a risk factor. 
      We aimed to estimate familial aggregation of AIRD in SLE patients and to compare 
      between ones having a positive and negative family history of autoimmunity in our 
      cohort. We included families of 157 consecutive SLE patients in a hospital-based, 
      cross-sectional design for a three-generation pedigree study. Clinical and 
      laboratory parameters of these patients were recorded. AIRD was seen in families 
      of 39 SLE patients amounting to a familial prevalence of 24.8% [95% confidence 
      interval (CI) 18.1, 31.6] with a relative risk (lambda) of 4.3 for first-degree 
      relatives (FDRs) and 1.1 for second-degree relatives (SDRs). SLE was the 
      commonest AIRD seen in families of 19 patients with a familial prevalence of 
      12.1% (95% CI 7.0, 17.2) and lambda of 78.2 for FDRs and 18.1 for SDRs. AIRD as a 
      whole and SLE alone were seen more commonly with parental consanguinity 
      (p < 0.05). Familial aggregation in SLE patients also showed a relatively higher 
      percentage of affected males and lesser presentation with constitutional features 
      (p < 0.05) than sporadic SLE patients. Rheumatoid arthritis (RA) was the second 
      most common AIRD seen in 16/39 (41%) families with a RR of 3.1 in FDRs of SLE 
      patients. In conclusion, Asian Indian SLE patients seem to have a high familial 
      aggregation of AIRD, which is more pronounced in the background of parental 
      consanguinity. SLE is the commonest AIRD seen amongst FDRs and SDRs of SLE 
      patients, followed by RA, with FDRs being at highest risk.
FAU - Ganapati, Arvind
AU  - Ganapati A
AD  - Department of Clinical Immunology and Rheumatology, Christian Medical College 
      Hospital, Vellore, India.
FAU - Arunachal, Gautham
AU  - Arunachal G
AD  - Department of Medical Genetics, Christian Medical College Hospital, Vellore, 
      India.
FAU - Arya, Suvrat
AU  - Arya S
AD  - Department of Clinical Immunology and Rheumatology, Christian Medical College 
      Hospital, Vellore, India.
FAU - Shanmugasundaram, Devika
AU  - Shanmugasundaram D
AD  - Department of Biostatistics, Christian Medical College Hospital, Vellore, India.
FAU - Jeyaseelan, Lakshmanan
AU  - Jeyaseelan L
AD  - Department of Biostatistics, Christian Medical College Hospital, Vellore, India.
FAU - Kumar, Sathish
AU  - Kumar S
AD  - Department of Child Health II, Christian Medical College Hospital, Vellore, 
      India.
FAU - Danda, Sumita
AU  - Danda S
AD  - Department of Medical Genetics, Christian Medical College Hospital, Vellore, 
      India.
FAU - Danda, Debashish
AU  - Danda D
AD  - Department of Clinical Immunology and Rheumatology, Christian Medical College 
      Hospital, Vellore, India. debashisdandacmc@hotmail.com.
LA  - eng
GR  - IRB 9459 dated 5/6/2015/Christian Medical College, Vellore/
PT  - Journal Article
DEP - 20190701
PL  - Germany
TA  - Rheumatol Int
JT  - Rheumatology international
JID - 8206885
RN  - 0 (Autoantibodies)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Autoantibodies/immunology
MH  - Autoimmune Diseases/*epidemiology/genetics/immunology
MH  - Autoimmunity
MH  - Comorbidity
MH  - Consanguinity
MH  - Cross-Sectional Studies
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - India
MH  - Lupus Erythematosus, Systemic/*epidemiology/genetics/immunology
MH  - Male
MH  - Middle Aged
MH  - Pedigree
MH  - Prevalence
MH  - Rheumatic Diseases/*epidemiology/genetics/immunology
MH  - Young Adult
OTO - NOTNLM
OT  - Autoimmune rheumatic disease
OT  - Familial autoimmunity
OT  - Familial lupus
OT  - Lupus
OT  - SLE
EDAT- 2019/07/03 06:00
MHDA- 2020/06/02 06:00
CRDT- 2019/07/03 06:00
PHST- 2019/05/08 00:00 [received]
PHST- 2019/06/20 00:00 [accepted]
PHST- 2019/07/03 06:00 [pubmed]
PHST- 2020/06/02 06:00 [medline]
PHST- 2019/07/03 06:00 [entrez]
AID - 10.1007/s00296-019-04355-z [pii]
AID - 10.1007/s00296-019-04355-z [doi]
PST - ppublish
SO  - Rheumatol Int. 2019 Dec;39(12):2053-2060. doi: 10.1007/s00296-019-04355-z. Epub 
      2019 Jul 1.