PMID- 31264106
OWN - NLM
STAT- MEDLINE
DCOM- 20200630
LR  - 20200630
IS  - 1435-165X (Electronic)
IS  - 1018-8827 (Linking)
VI  - 29
IP  - 4
DP  - 2020 Apr
TI  - Effects of BDNF Val66Met polymorphisms on brain structures and behaviors in 
      adolescents with conduct disorder.
PG  - 479-488
LID - 10.1007/s00787-019-01363-z [doi]
AB  - Accumulating evidence suggests that neural abnormalities in conduct disorder (CD) 
      may be subject to genetic influences, but few imaging studies have taken genetic 
      variants into consideration. The Val66Met polymorphism of brain-derived 
      neurotrophic factor (BDNF) has emerged as a high-interest genetic variant due to 
      its importance in cortical maturation, and several studies have implicated its 
      involvement in neurodevelopmental disorders. Thus, it is unclear how this 
      polymorphism may influence brain anatomy and aberrant behaviors in CD. A total of 
      65 male adolescents with CD and 69 gender-, IQ- and socioeconomic status-matched 
      healthy controls (HCs) (age range 13-17 years) were enrolled in this study. 
      Analyses of variance (ANOVAs) were used to assess the main effects of CD 
      diagnosis, BDNF genotype, and diagnosis-genotype interactions on brain anatomy 
      and behaviors. We detected a significant main effect of BDNF genotype on temporal 
      gyrification and antisocial behaviors, but not on CD symptoms. Diagnosis-genotype 
      interactive effects were found for cortical thickness of the superior temporal 
      and adjacent areas. These results suggest that the BDNF Val66Met polymorphism may 
      exert its influence both on neural alterations and delinquent behaviors in CD 
      patients. This initial evidence highlights the importance of elucidating 
      potentially different pathways between BDNF genotype and cortical alterations or 
      delinquent behaviors in CD patients.
FAU - Jiang, Yali
AU  - Jiang Y
AD  - Medical Psychological Center, The Second Xiangya Hospital, Central South 
      University, No. 139, Middle Renmin Road, Changsha, 410011, Hunan, People's 
      Republic of China.
AD  - Center for Studies of Psychological Application, School of Psychology, South 
      China Normal University, Guangzhou, Guangdong, People's Republic of China.
FAU - Ming, Qingsen
AU  - Ming Q
AD  - Medical Psychological Center, The Second Xiangya Hospital, Central South 
      University, No. 139, Middle Renmin Road, Changsha, 410011, Hunan, People's 
      Republic of China.
FAU - Gao, Yidian
AU  - Gao Y
AD  - Medical Psychological Center, The Second Xiangya Hospital, Central South 
      University, No. 139, Middle Renmin Road, Changsha, 410011, Hunan, People's 
      Republic of China.
FAU - Dong, Daifeng
AU  - Dong D
AD  - Medical Psychological Center, The Second Xiangya Hospital, Central South 
      University, No. 139, Middle Renmin Road, Changsha, 410011, Hunan, People's 
      Republic of China.
FAU - Sun, Xiaoqiang
AU  - Sun X
AD  - Medical Psychological Center, The Second Xiangya Hospital, Central South 
      University, No. 139, Middle Renmin Road, Changsha, 410011, Hunan, People's 
      Republic of China.
FAU - Zhang, Xiaocui
AU  - Zhang X
AD  - Medical Psychological Center, The Second Xiangya Hospital, Central South 
      University, No. 139, Middle Renmin Road, Changsha, 410011, Hunan, People's 
      Republic of China.
FAU - Situ, Weijun
AU  - Situ W
AD  - Department of Radiology, The Second Xiangya Hospital, Central South University, 
      Changsha, Hunan, People's Republic of China.
FAU - Yao, Shuqiao
AU  - Yao S
AD  - Medical Psychological Center, The Second Xiangya Hospital, Central South 
      University, No. 139, Middle Renmin Road, Changsha, 410011, Hunan, People's 
      Republic of China. shuqiaoyao@csu.edu.cn.
AD  - National Clinical Research Center on Psychiatry and Psychology, Changsha, Hunan, 
      People's Republic of China. shuqiaoyao@csu.edu.cn.
AD  - Medical Psychological Institute of Central South University, Changsha, Hunan, 
      People's Republic of China. shuqiaoyao@csu.edu.cn.
FAU - Rao, Hengyi
AU  - Rao H
AD  - Center of Functional Neuroimaging, Department of Neurology, Perelman School of 
      Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
LA  - eng
GR  - 81471384/Natural Science Foundation of China/
GR  - 20130162110043/Specialized Research Fund for the Doctoral Program of Higher 
      Education/
PT  - Journal Article
DEP - 20190701
PL  - Germany
TA  - Eur Child Adolesc Psychiatry
JT  - European child & adolescent psychiatry
JID - 9212296
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adolescent
MH  - Brain/*pathology
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - Conduct Disorder/*genetics
MH  - Female
MH  - Humans
MH  - Male
MH  - Polymorphism, Genetic/*genetics
OTO - NOTNLM
OT  - Adolescents
OT  - Antisocial behavior
OT  - Brain-derived neurotrophic factor
OT  - Conduct disorder
OT  - Surface-based morphometry
EDAT- 2019/07/03 06:00
MHDA- 2020/07/01 06:00
CRDT- 2019/07/03 06:00
PHST- 2018/11/06 00:00 [received]
PHST- 2019/06/24 00:00 [accepted]
PHST- 2019/07/03 06:00 [pubmed]
PHST- 2020/07/01 06:00 [medline]
PHST- 2019/07/03 06:00 [entrez]
AID - 10.1007/s00787-019-01363-z [pii]
AID - 10.1007/s00787-019-01363-z [doi]
PST - ppublish
SO  - Eur Child Adolesc Psychiatry. 2020 Apr;29(4):479-488. doi: 
      10.1007/s00787-019-01363-z. Epub 2019 Jul 1.