PMID- 31265832
OWN - NLM
STAT- MEDLINE
DCOM- 20200528
LR  - 20220120
IS  - 1931-3543 (Electronic)
IS  - 0012-3692 (Print)
IS  - 0012-3692 (Linking)
VI  - 156
IP  - 6
DP  - 2019 Dec
TI  - Monitoring Pulmonary Arterial Hypertension Using an Implantable Hemodynamic 
      Sensor.
PG  - 1176-1186
LID - S0012-3692(19)31238-3 [pii]
LID - 10.1016/j.chest.2019.06.010 [doi]
AB  - BACKGROUND: Pulmonary arterial hypertension (PAH) is a chronic disease that 
      ultimately progresses to right-sided heart failure (HF) and death. Close 
      monitoring of pulmonary artery pressure (PAP) and right ventricular (RV) function 
      allows clinicians to appropriately guide therapy. However, the burden of commonly 
      used methods to assess RV hemodynamics, such as right heart catheterization, 
      precludes frequent monitoring. The CardioMEMS HF System (Abbott) is an ambulatory 
      implantable hemodynamic monitor, previously only used in patients with New York 
      Heart Association (NYHA) class III HF. In this study, we evaluate the feasibility 
      and early safety of monitoring patients with PAH and right-sided HF using the 
      CardioMEMS HF System. METHODS: The CardioMEMS HF sensors were implanted in 26 
      patients with PAH with NYHA class III or IV right-sided HF (51.3 +/- 18.3 years of 
      age, 92% women, 81% NYHA class III). PAH therapy was tracked using a minimum of 
      weekly reviews of CardioMEMS HF daily hemodynamic measurements. Safety, 
      functional response, and hemodynamic response were tracked up to 4 years with 
      in-clinic follow-ups. RESULTS: The CardioMEMS HF System was safely used to 
      monitor PAH therapy, with no device-related serious adverse events observed and a 
      single preimplant serious adverse event. Significant PAP reduction and cardiac 
      output elevation were observed as early as 1 month postimplant using trends of 
      CardioMEMS HF data, coupled with significant NYHA class and quality of life 
      improvements within 1 year. CONCLUSIONS: The CardioMEMS HF System provided useful 
      information to monitor PAH therapy, and demonstrated short- and long-term safety. 
      Larger clinical trials are needed before its widespread use to guide therapy in 
      patients with severe PAH with right-sided HF.
CI  - Copyright (c) 2019 American College of Chest Physicians. Published by Elsevier Inc. 
      All rights reserved.
FAU - Benza, Raymond L
AU  - Benza RL
AD  - Cardiovascular Institute, Allegheny General Hospital, Pittsburgh, PA. Electronic 
      address: rbenza@wpahs.org.
FAU - Doyle, Mark
AU  - Doyle M
AD  - Cardiovascular Institute, Allegheny General Hospital, Pittsburgh, PA.
FAU - Lasorda, David
AU  - Lasorda D
AD  - Cardiovascular Institute, Allegheny General Hospital, Pittsburgh, PA.
FAU - Parikh, Kishan S
AU  - Parikh KS
AD  - Duke Clinical Research Institute, Durham, NC.
FAU - Correa-Jaque, Priscilla
AU  - Correa-Jaque P
AD  - Cardiovascular Institute, Allegheny General Hospital, Pittsburgh, PA.
FAU - Badie, Nima
AU  - Badie N
AD  - Abbott, Sylmar, CA.
FAU - Ginn, Greg
AU  - Ginn G
AD  - Abbott, Sylmar, CA.
FAU - Airhart, Sophia
AU  - Airhart S
AD  - University of Arizona Medical Center, Tucson, AZ.
FAU - Franco, Veronica
AU  - Franco V
AD  - Ohio State University, Columbus, OH.
FAU - Kanwar, Manreet K
AU  - Kanwar MK
AD  - Cardiovascular Institute, Allegheny General Hospital, Pittsburgh, PA.
FAU - Murali, Srinivas
AU  - Murali S
AD  - Cardiovascular Institute, Allegheny General Hospital, Pittsburgh, PA.
FAU - Raina, Amresh
AU  - Raina A
AD  - Cardiovascular Institute, Allegheny General Hospital, Pittsburgh, PA.
FAU - Agarwal, Rahul
AU  - Agarwal R
AD  - Abbott, Sylmar, CA.
FAU - Rajagopal, Sudarshan
AU  - Rajagopal S
AD  - Duke Clinical Research Institute, Durham, NC.
FAU - White, Jason
AU  - White J
AD  - Abbott, Sylmar, CA.
FAU - Biederman, Robert
AU  - Biederman R
AD  - Cardiovascular Institute, Allegheny General Hospital, Pittsburgh, PA.
LA  - eng
GR  - HHSN268201400008C/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20190629
PL  - United States
TA  - Chest
JT  - Chest
JID - 0231335
SB  - IM
CIN - Am J Respir Crit Care Med. 2022 Jan 15;205(2):242-244. PMID: 34714222
MH  - Adult
MH  - Aged
MH  - Blood Pressure Monitoring, Ambulatory/adverse effects/*instrumentation
MH  - Feasibility Studies
MH  - Female
MH  - Heart Failure/*diagnosis/etiology
MH  - Hemodynamic Monitoring/adverse effects/*instrumentation
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Prostheses and Implants/adverse effects
MH  - Pulmonary Arterial Hypertension/complications/*diagnosis
PMC - PMC6904858
OTO - NOTNLM
OT  - CardioMEMS
OT  - hemodynamics
OT  - pulmonary hypertension
OT  - ride-sided heart failure
EDAT- 2019/07/03 06:00
MHDA- 2020/05/29 06:00
PMCR- 2020/12/01
CRDT- 2019/07/03 06:00
PHST- 2019/01/17 00:00 [received]
PHST- 2019/05/23 00:00 [revised]
PHST- 2019/06/18 00:00 [accepted]
PHST- 2019/07/03 06:00 [pubmed]
PHST- 2020/05/29 06:00 [medline]
PHST- 2019/07/03 06:00 [entrez]
PHST- 2020/12/01 00:00 [pmc-release]
AID - S0012-3692(19)31238-3 [pii]
AID - 10.1016/j.chest.2019.06.010 [doi]
PST - ppublish
SO  - Chest. 2019 Dec;156(6):1176-1186. doi: 10.1016/j.chest.2019.06.010. Epub 2019 Jun 
      29.