PMID- 31271009
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20190704
IS  - 1872-2059 (Electronic)
IS  - 1000-8713 (Linking)
VI  - 37
IP  - 7
DP  - 2019 Jul 8
TI  - [Determination of 50 non-edible additives in health food using the QuEChERS 
      method and liquid chromatography-tandem mass spectrometry].
PG  - 701-711
LID - 10.3724/SP.J.1123.2019.01046 [doi]
AB  - A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was 
      established for the determination of 50 non-food additives in health food. The 
      samples were extracted with methanol and purified using the QuEChERS method. The 
      separation was performed on an Agilent Phoroshell SB C(18) column (150 mmx3.0 mm, 
      2.7 mum) with a mobile phase of 0.1% (v/v) formic acid aqueous solution and 
      acetonitrile. The determination was performed by MS/MS in positive or negative 
      electrospray ionization and multiple reaction monitoring mode. The results 
      demonstrated that all 50 compounds could be well separated with a good linear 
      relationship (r(2)>0.99). The limits of detection (LODs, S/N >/= 3) and limits of 
      quantification (LOQs, S/N >/= 10) were in the range of 0.010-1 mg/kg and 0.020-2 
      mg/kg, respectively. The matrix effects in five kinds of typical health foods 
      (oral liquid, tablets, ointments, pills, and capsules) were evaluated and reduced 
      by means of matrix matching. At the spiked levels of 1 LOQ, 2 LOQ, and 10 LOQ, 
      the recoveries of all drugs varied from 63.1% to 115.7% with relative standard 
      deviations (RSDs) of no more than 8.9% (n=6). The method is simple, sensitive, 
      practical, and suitable for monitoring 50 non-edible additives in health food.
FAU - Hu, Shengjie
AU  - Hu S
AD  - Department of Food Engineering, School of Life Science, Shanghai University, 
      Shanghai 200444, China.
FAU - Li, You
AU  - Li Y
AD  - Animal, Plant and Food Inspection & Quarantine Center, Shanghai Entry-Exit 
      Inspection and Quarantine Bureau, Shanghai 200135, China.
FAU - Zhou, Ying
AU  - Zhou Y
AD  - Sanda University, Shanghai 201209, China.
FAU - Yi, Xionghai
AU  - Yi X
AD  - Animal, Plant and Food Inspection & Quarantine Center, Shanghai Entry-Exit 
      Inspection and Quarantine Bureau, Shanghai 200135, China.
FAU - Deng, Xiaojun
AU  - Deng X
AD  - Animal, Plant and Food Inspection & Quarantine Center, Shanghai Entry-Exit 
      Inspection and Quarantine Bureau, Shanghai 200135, China.
FAU - Chen, Qin
AU  - Chen Q
AD  - Department of Food Engineering, School of Life Science, Shanghai University, 
      Shanghai 200444, China.
FAU - Xu, Dunming
AU  - Xu D
AD  - Inspection and Quarantine Technology Center, Xiamen Entry-Exit Inspection and 
      Quarantine Bureau, Xiamen 361012, China.
FAU - Niu, Bing
AU  - Niu B
AD  - Department of Food Engineering, School of Life Science, Shanghai University, 
      Shanghai 200444, China.
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Se Pu
JT  - Se pu = Chinese journal of chromatography
JID - 9424804
OTO - NOTNLM
OT  - QuEChERS
OT  - health food
OT  - liquid chromatography-tandem mass spectrometry (LC-MS/MS)
OT  - non-edible additives
EDAT- 2019/07/05 06:00
MHDA- 2019/07/05 06:01
CRDT- 2019/07/05 06:00
PHST- 2019/07/05 06:00 [entrez]
PHST- 2019/07/05 06:00 [pubmed]
PHST- 2019/07/05 06:01 [medline]
AID - 10.3724/SP.J.1123.2019.01046 [doi]
PST - ppublish
SO  - Se Pu. 2019 Jul 8;37(7):701-711. doi: 10.3724/SP.J.1123.2019.01046.