PMID- 31271528 OWN - NLM STAT- MEDLINE DCOM- 20200210 LR - 20200210 IS - 1751-553X (Electronic) IS - 1751-5521 (Linking) VI - 41 IP - 5 DP - 2019 Oct TI - Performance evaluation of new Abbott Alinity hq hematology analyzer. PG - 657-663 LID - 10.1111/ijlh.13082 [doi] AB - INTRODUCTION: Abbott Alinity hq is a next-generation automated hematology analyzer providing complete blood count (CBC) with 6-part white blood cells (WBC) differential counts. The purpose of this study was to evaluate the performance of the analyzer to verify the diagnostic and clinical utility of the Abbott Alinity hq automated system. METHODS: We evaluated specimen stability, precision, linearity, carry-over, and method comparison to assess the performance of Alinity hq. For comparison of the Alinity hq with Sysmex XN-9000, totally 314 samples from adult and pediatric patients including both normal and abnormal hematology profiles were analyzed in parallel. The Alinity hq was also compared with the manual differential counts for the same 314 samples. RESULTS: At 4 degrees C, the Alinity hq analyzer showed no significant changes in CBC and WBC differential count up to 48 hours. When stored at room temperature (18-25 degrees C), all parameters except the mean platelet volume (MPV) were stable up to 36 hours. The Abbott Alinity hq analyzer demonstrated excellent reproducibility and between-batch precision for all CBC and WBC differential parameters. WBC, red blood cells (RBC), hemoglobin (HGB), and platelets showed good linearity and acceptable carry-over. Comparison with a Sysmex XN-9000 analyzer and manual 400-cell differential showed excellent correlation for CBC and WBC differential count parameters (correlation coefficient = 0.815-0.999) except for mean corpuscular hemoglobin concentration (MCHC) and basophils. CONCLUSION: We performed initial validation studies and confirmed performance specifications on specimen stability, precision, linearity, carry-over, and method comparison. The Abbott Alinity hq analyzer showed good analytical performance for all standard CBC parameters. CI - (c) 2019 John Wiley & Sons Ltd. FAU - Woo, Kwang-Sook AU - Woo KS AUID- ORCID: 0000-0002-3674-8534 AD - Department of Laboratory Medicine, Dong-A University College of Medicine, Busan, Korea. FAU - Jeong, In-Hwa AU - Jeong IH AD - Department of Laboratory Medicine, Dong-A University College of Medicine, Busan, Korea. FAU - An, Gyu-Dae AU - An GD AUID- ORCID: 0000-0001-9738-4204 AD - Department of Laboratory Medicine, Dong-A University College of Medicine, Busan, Korea. FAU - Lim, Hyeon-Ho AU - Lim HH AUID- ORCID: 0000-0002-8307-9820 AD - Department of Laboratory Medicine, Dong-A University College of Medicine, Busan, Korea. FAU - Han, Jin-Yeong AU - Han JY AUID- ORCID: 0000-0003-0280-2739 AD - Department of Laboratory Medicine, Dong-A University College of Medicine, Busan, Korea. LA - eng GR - Dong-A University/ PT - Evaluation Study PT - Journal Article DEP - 20190704 PL - England TA - Int J Lab Hematol JT - International journal of laboratory hematology JID - 101300213 RN - 0 (Hemoglobins) SB - IM MH - Adult MH - Blood Cell Count/*instrumentation/methods MH - Child MH - Erythrocyte Count/*instrumentation/methods MH - Hematology/*instrumentation/methods MH - Hemoglobins/*analysis MH - Humans MH - Leukocyte Count/*instrumentation/methods MH - Platelet Count/*instrumentation/methods MH - Reproducibility of Results OTO - NOTNLM OT - Abbott Alinity hq OT - complete blood count OT - differential count OT - hematology analyzer OT - performance EDAT- 2019/07/05 06:00 MHDA- 2020/02/11 06:00 CRDT- 2019/07/05 06:00 PHST- 2019/01/14 00:00 [received] PHST- 2019/05/31 00:00 [revised] PHST- 2019/06/14 00:00 [accepted] PHST- 2019/07/05 06:00 [pubmed] PHST- 2020/02/11 06:00 [medline] PHST- 2019/07/05 06:00 [entrez] AID - 10.1111/ijlh.13082 [doi] PST - ppublish SO - Int J Lab Hematol. 2019 Oct;41(5):657-663. doi: 10.1111/ijlh.13082. Epub 2019 Jul 4.