PMID- 31272272
OWN - NLM
STAT- MEDLINE
DCOM- 20191227
LR  - 20191227
IS  - 1502-7732 (Electronic)
IS  - 0300-9742 (Linking)
VI  - 48
IP  - 6
DP  - 2019 Nov
TI  - Dynamics of immunocyte activation during intravenous immunoglobulin treatment in 
      Kawasaki disease.
PG  - 491-496
LID - 10.1080/03009742.2019.1604992 [doi]
AB  - Objectives: Kawasaki disease (KD) is a systemic vasculitis of early childhood. 
      Intravenous immunoglobulin (IVIG) is the standard treatment for KD. However, IVIG 
      is not effective in approximately 15% of children with KD, and the mechanisms for 
      this are unclear. We investigated changes in monocyte and T-cell activation from 
      pre- to post-IVIG in IVIG-effective and IVIG-resistant KD.Method: We analysed 
      peripheral CD14(+)CD16(+) cells and human leucocyte antigen-DR (HLA-DR) 
      expression on CD4(+) and CD8(+) cells in 46 children with KD who were admitted to 
      Yamaguchi University Hospital between January 2011 and May 2016. We compared the 
      kinetics in the absolute numbers of CD14(+)CD16(+) cells, CD4(+)HLA-DR(+) cells, 
      and CD8(+)HLA-DR(+) cells before and after IVIG treatment between IVIG-effective 
      and IVIG-resistant groups.Results: Among the 46 subjects, 30 had IVIG-effective 
      KD and 16 had IVIG-resistant KD. The absolute number of CD14(+)CD16(+) cells in 
      the IVIG-effective group decreased significantly after IVIG, while that in the 
      IVIG-resistant group showed no change after IVIG. The absolute number of 
      CD4(+)HLA-DR(+) cells increased significantly after IVIG in both groups. The 
      absolute number of CD8(+)HLA-DR(+) cells before IVIG was low and significantly 
      increased after IVIG in the IVIG-resistant group, while that in the 
      IVIG-effective group showed no change after IVIG.Conclusions: Our results suggest 
      that insufficient control of monocyte suppression and T-cell activation, 
      especially in terms of the CD8-related immune system, are associated with IVIG 
      resistance. The restoration of T-cell suppression may be important for KD 
      recovery. These findings provide insight into the mechanism of IVIG resistance.
FAU - Matsuguma, C
AU  - Matsuguma C
AD  - Department of Pediatrics, Yamaguchi University Graduate School of Medicine, Ube, 
      Japan.
FAU - Wakiguchi, H
AU  - Wakiguchi H
AD  - Department of Pediatrics, Yamaguchi University Graduate School of Medicine, Ube, 
      Japan.
FAU - Suzuki, Y
AU  - Suzuki Y
AD  - Department of Pediatrics, Yamaguchi University Graduate School of Medicine, Ube, 
      Japan.
FAU - Okada, S
AU  - Okada S
AD  - Department of Pediatrics, Yamaguchi University Graduate School of Medicine, Ube, 
      Japan.
FAU - Furuta, T
AU  - Furuta T
AD  - Department of Pediatrics, Yamaguchi University Graduate School of Medicine, Ube, 
      Japan.
FAU - Ohnishi, Y
AU  - Ohnishi Y
AD  - Department of Pediatrics, Yamaguchi University Graduate School of Medicine, Ube, 
      Japan.
FAU - Azuma, Y
AU  - Azuma Y
AD  - Department of Pediatrics, Yamaguchi University Graduate School of Medicine, Ube, 
      Japan.
FAU - Ohga, S
AU  - Ohga S
AD  - Department of Pediatrics, Yamaguchi University Graduate School of Medicine, Ube, 
      Japan.
AD  - Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, 
      Fukuoka, Japan.
FAU - Hasegawa, S
AU  - Hasegawa S
AD  - Department of Pediatrics, Yamaguchi University Graduate School of Medicine, Ube, 
      Japan.
LA  - eng
PT  - Journal Article
DEP - 20190705
PL  - England
TA  - Scand J Rheumatol
JT  - Scandinavian journal of rheumatology
JID - 0321213
RN  - 0 (HLA-DR Antigens)
RN  - 0 (Immunoglobulins, Intravenous)
SB  - IM
MH  - CD4-Positive T-Lymphocytes/*immunology
MH  - CD8-Positive T-Lymphocytes/*immunology
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - HLA-DR Antigens/analysis
MH  - Humans
MH  - Immunoglobulins, Intravenous/*therapeutic use
MH  - Infant
MH  - *Lymphocyte Activation
MH  - Male
MH  - Monocytes/*immunology
MH  - Mucocutaneous Lymph Node Syndrome/*drug therapy/immunology
EDAT- 2019/07/06 06:00
MHDA- 2019/12/28 06:00
CRDT- 2019/07/06 06:00
PHST- 2019/07/06 06:00 [pubmed]
PHST- 2019/12/28 06:00 [medline]
PHST- 2019/07/06 06:00 [entrez]
AID - 10.1080/03009742.2019.1604992 [doi]
PST - ppublish
SO  - Scand J Rheumatol. 2019 Nov;48(6):491-496. doi: 10.1080/03009742.2019.1604992. 
      Epub 2019 Jul 5.