PMID- 31272903 OWN - NLM STAT- MEDLINE DCOM- 20200601 LR - 20200601 IS - 1440-1592 (Electronic) IS - 1323-8930 (Linking) VI - 69 IP - 1 DP - 2020 Jan TI - Correlation between eosinophil count, its genetic background and body mass index: The Nagahama Study. PG - 46-52 LID - S1323-8930(19)30080-2 [pii] LID - 10.1016/j.alit.2019.05.012 [doi] AB - BACKGROUND: Obesity affects the pathogenesis of various chronic diseases, including asthma. Research on correlations between obesity/BMI and eosinophilic inflammation in asthma has yielded contradictory results, which could be partly ascribed to the absence of epidemiological data on the correlations. We aimed to elucidate the correlations between blood eosinophil count, its genetic backgrounds, and BMI in the general population. METHODS: This community-based Nagahama study in Japan enrolled 9789 inhabitants. We conducted self-reporting questionnaires, lung function tests, and blood tests in the baseline and 5-year follow-up studies. A genome-wide association study (GWAS) was performed in 4650 subjects at the baseline and in 4206 of these at the follow-up to determine single-nucleotide polymorphisms for elevated blood eosinophil counts. We assessed the correlations between BMI and eosinophil counts using a multifaceted approach, including the cluster analysis. RESULTS: Eosinophil counts positively correlated with BMI, observed upon the interchange of an explanatory variable, except for subjects with the highest quartile of eosinophils (>/=200/muL), in whom BMI negatively correlated with eosinophil counts. GWAS and human leukocyte antigen (HLA) imputation identified rs4713354 variant (MDC1 on chromosome 6p21) for elevated eosinophil counts, independent of BMI and IgE. Rs4713354 was accumulated in a cluster characterized by elevated eosinophil counts (mean, 498 +/- 178/muL) but normal BMI. CONCLUSIONS: Epidemiologically, there may be a positive association between blood eosinophil counts and BMI in general, but there was a negative correlation in the population with high eosinophil counts. Factors other than BMI, particularly genetic backgrounds, may contribute to elevated eosinophil counts in such populations. CI - Copyright (c) 2019 Japanese Society of Allergology. Production and hosting by Elsevier B.V. All rights reserved. FAU - Sunadome, Hironobu AU - Sunadome H AD - Department of Respiratory Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan. FAU - Matsumoto, Hisako AU - Matsumoto H AD - Department of Respiratory Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan. Electronic address: hmatsumo@kuhp.kyoto-u.ac.jp. FAU - Izuhara, Yumi AU - Izuhara Y AD - Department of Respiratory Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan. FAU - Nagasaki, Tadao AU - Nagasaki T AD - Department of Respiratory Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan. FAU - Kanemitsu, Yoshihiro AU - Kanemitsu Y AD - Department of Respiratory Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan; Department of Respiratory Medicine, Allergy and Clinical Immunology, Nagoya City University School of Medical Sciences, Nagoya, Japan. FAU - Ishiyama, Yumi AU - Ishiyama Y AD - Department of Respiratory Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan. FAU - Morimoto, Chie AU - Morimoto C AD - Department of Respiratory Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan. FAU - Oguma, Tsuyoshi AU - Oguma T AD - Department of Respiratory Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan. FAU - Ito, Isao AU - Ito I AD - Department of Respiratory Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan. FAU - Murase, Kimihiko AU - Murase K AD - Department of Respiratory Care and Sleep Control Medicine, Kyoto University, Graduate School of Medicine, Kyoto, Japan. FAU - Muro, Shigeo AU - Muro S AD - Department of Respiratory Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan; Department of Respiratory Medicine, Nara Medical University, Nara, Japan. FAU - Kawaguchi, Takahisa AU - Kawaguchi T AD - Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan. FAU - Tabara, Yasuharu AU - Tabara Y AD - Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan. FAU - Chin, Kazuo AU - Chin K AD - Department of Respiratory Care and Sleep Control Medicine, Kyoto University, Graduate School of Medicine, Kyoto, Japan. FAU - Matsuda, Fumihiko AU - Matsuda F AD - Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan. FAU - Hirai, Toyohiro AU - Hirai T AD - Department of Respiratory Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan. LA - eng PT - Journal Article DEP - 20190702 PL - England TA - Allergol Int JT - Allergology international : official journal of the Japanese Society of Allergology JID - 9616296 SB - IM MH - Adult MH - Aged MH - Asthma/*epidemiology MH - Body Mass Index MH - Eosinophilia/*epidemiology/genetics MH - Eosinophils MH - Female MH - Genetic Background MH - Genome-Wide Association Study MH - Humans MH - Japan MH - Leukocyte Count MH - Male MH - Middle Aged MH - Obesity/*epidemiology MH - Polymorphism, Single Nucleotide OTO - NOTNLM OT - BMI OT - Cluster analysis OT - Eosinophil OT - Epidemiological study OT - Genome-wide association study EDAT- 2019/07/06 06:00 MHDA- 2020/06/02 06:00 CRDT- 2019/07/06 06:00 PHST- 2019/01/10 00:00 [received] PHST- 2019/05/07 00:00 [revised] PHST- 2019/05/21 00:00 [accepted] PHST- 2019/07/06 06:00 [pubmed] PHST- 2020/06/02 06:00 [medline] PHST- 2019/07/06 06:00 [entrez] AID - S1323-8930(19)30080-2 [pii] AID - 10.1016/j.alit.2019.05.012 [doi] PST - ppublish SO - Allergol Int. 2020 Jan;69(1):46-52. doi: 10.1016/j.alit.2019.05.012. Epub 2019 Jul 2.