PMID- 31273538
OWN - NLM
STAT- MEDLINE
DCOM- 20200205
LR  - 20200205
IS  - 1572-8781 (Electronic)
IS  - 1387-2176 (Linking)
VI  - 21
IP  - 3
DP  - 2019 Jul 4
TI  - CoCrMo alloys ions release behavior by TiNbN coating: an in vitro study.
PG  - 61
LID - 10.1007/s10544-019-0417-6 [doi]
AB  - The aim of the study was to show in vitro the greater inertness to the corrosion 
      body fluid of TiNbN coating than the CoCrMo alloy substrate. The prosthetic 
      component under study was a femoral component of total knee prosthesis in CoCrMo 
      alloy coated in TiNbN with Physical Vapor Deposition technique immersed in static 
      Hank's balanced salt solution (HBS) (pH = 6) for at least 34 months at a constant 
      temperature of 37  degrees C. Another uncoated prosthetic component of CoCrMo alloy with 
      the same type and size was left in static immersion in the same solution and for 
      the same period of time. Scanning electron microscope (SEM) analysis was 
      performed to investigate adhesion and proliferation at 24, 48, 72 h after seeding 
      of 10(4) sub-confluents osteoblast-like cells (SaOS-2) cells on scaffold. The 
      results of the study showed a reduction in the concentration of the metal ions 
      released from the TiNbN-coated femoral component surface compared to the uncoated 
      surface in the HBS solution. The overall reduction of the ions for the 
      TiNbN-coated femoral component compared to the uncoated one was 80.1 +/- 2%, 
      62.5% +/- 8% and 48% +/- 10% for Co, Cr, Mo, respectively (p < 0.01). SEM analysis 
      confirmed the healthy state of the cells, the cellular adhesion and proliferation 
      of SaOS-2 on the TiNbN-coated specimen. Although the results observed in vitro 
      for the TiNbN coating are encouraging, clinical studies are certainly needed to 
      be performed in order to understand how these positive findings can be translated 
      in vivo and to determine the clinical benefit of TiNbN coating.
FAU - Ragone, Vincenza
AU  - Ragone V
AD  - Research and Development Department, Permedica S.p.A., Via Como 38, Merate (LC), 
      Italy.
FAU - Canciani, Elena
AU  - Canciani E
AD  - Department of Biomedical, Surgical and Dental Sciences, Universita degli Studi di 
      Milano, Milan, Italy.
FAU - Biffi, Carlo Alberto
AU  - Biffi CA
AD  - National Research Council, Institute of Condensed Matter Chemistry and 
      Technologies for Energy, Unit of Lecco, CNR ICMATE, Lecco, Italy.
FAU - D'Ambrosi, Riccardo
AU  - D'Ambrosi R
AUID- ORCID: 0000-0002-1216-792X
AD  - IRCCS Orthopedic Institute Galeazzi, Milan, Italy. riccardo.dambrosi@hotmail.it.
FAU - Sanvito, Rossella
AU  - Sanvito R
AD  - Research and Development Department, Permedica S.p.A., Via Como 38, Merate (LC), 
      Italy.
FAU - Dellavia, Claudia
AU  - Dellavia C
AD  - Department of Biomedical, Surgical and Dental Sciences, Universita degli Studi di 
      Milano, Milan, Italy.
FAU - Galliera, Emanuela
AU  - Galliera E
AD  - IRCCS Orthopedic Institute Galeazzi, Milan, Italy.
AD  - Milan Department of Biomedical Sciences for Health, Universita degli Studi di 
      Milano, Milan, Italy.
LA  - eng
PT  - Journal Article
DEP - 20190704
PL  - United States
TA  - Biomed Microdevices
JT  - Biomedical microdevices
JID - 100887374
RN  - 0 (Coated Materials, Biocompatible)
RN  - 0 (titanium niobium nitride)
RN  - 05175J654G (Niobium)
RN  - 12629-02-6 (Vitallium)
RN  - D1JT611TNE (Titanium)
SB  - IM
MH  - Cell Adhesion/drug effects
MH  - Cell Line
MH  - Cell Proliferation/drug effects
MH  - Coated Materials, Biocompatible/*chemistry/*pharmacology
MH  - Knee Prosthesis
MH  - Materials Testing
MH  - Niobium/*chemistry
MH  - Osteoblasts/cytology/drug effects
MH  - Surface Properties
MH  - Titanium/*chemistry
MH  - Vitallium/*chemistry/*pharmacology
OTO - NOTNLM
OT  - Biocompatibility
OT  - Biocorrosion
OT  - Cobalt-chromium alloy
OT  - Immersion test
OT  - Titanium niobium nitride coating
EDAT- 2019/07/06 06:00
MHDA- 2020/02/06 06:00
CRDT- 2019/07/06 06:00
PHST- 2019/07/06 06:00 [entrez]
PHST- 2019/07/06 06:00 [pubmed]
PHST- 2020/02/06 06:00 [medline]
AID - 10.1007/s10544-019-0417-6 [pii]
AID - 10.1007/s10544-019-0417-6 [doi]
PST - epublish
SO  - Biomed Microdevices. 2019 Jul 4;21(3):61. doi: 10.1007/s10544-019-0417-6.