PMID- 31274511
OWN - NLM
STAT- MEDLINE
DCOM- 20200406
LR  - 20200408
IS  - 1572-0241 (Electronic)
IS  - 0002-9270 (Linking)
VI  - 114
IP  - 10
DP  - 2019 Oct
TI  - A Clinician's Guide to Celiac Disease HLA Genetics.
PG  - 1587-1592
LID - 10.14309/ajg.0000000000000310 [doi]
AB  - Celiac disease is a common inflammatory disease triggered by dietary gluten in 
      genetically susceptible individuals. The strongest and best-characterized genetic 
      susceptibilities in celiac disease are class II human leukocyte antigen (HLA) 
      genes known as HLA-DQ2 and DQ8. HLA genetic testing is available through a number 
      of commercial and academic laboratories and is used in the evaluation of celiac 
      disease and to identify at-risk family members. Importantly, HLA genetic testing 
      has a high negative predictive value for celiac disease, but a low positive 
      predictive value. Therefore, for a practicing clinician, it is important to 
      understand when to order HLA genetic testing, what test to order, and how to 
      interpret the result. This review provides a practical primer on HLA genetics in 
      celiac disease.
FAU - Brown, Nicholas K
AU  - Brown NK
AD  - Department of Pathology, University of Chicago, Chicago, Illinois, USA.
FAU - Guandalini, Stefano
AU  - Guandalini S
AD  - Celiac Disease Center, University of Chicago, Chicago, Illinois, USA.
FAU - Semrad, Carol
AU  - Semrad C
AD  - Celiac Disease Center, University of Chicago, Chicago, Illinois, USA.
FAU - Kupfer, Sonia S
AU  - Kupfer SS
AD  - Celiac Disease Center, University of Chicago, Chicago, Illinois, USA.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Am J Gastroenterol
JT  - The American journal of gastroenterology
JID - 0421030
RN  - 0 (Biomarkers)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ2 antigen)
RN  - 0 (HLA-DQ8 antigen)
RN  - 8002-80-0 (Glutens)
SB  - IM
MH  - Biomarkers/blood
MH  - Biopsy
MH  - Celiac Disease/blood/*diagnosis/genetics/immunology
MH  - Duodenum/immunology/metabolism/pathology
MH  - Gastroenterology/standards
MH  - Genetic Predisposition to Disease
MH  - Genetic Testing/*standards
MH  - Glutens/immunology/metabolism
MH  - HLA-DQ Antigens/*genetics/immunology
MH  - Humans
MH  - Intestinal Absorption/genetics/immunology
MH  - Intestinal Mucosa/immunology/metabolism/pathology
MH  - *Practice Guidelines as Topic
MH  - Predictive Value of Tests
EDAT- 2019/07/06 06:00
MHDA- 2020/04/09 06:00
CRDT- 2019/07/06 06:00
PHST- 2019/07/06 06:00 [pubmed]
PHST- 2020/04/09 06:00 [medline]
PHST- 2019/07/06 06:00 [entrez]
AID - 10.14309/ajg.0000000000000310 [doi]
PST - ppublish
SO  - Am J Gastroenterol. 2019 Oct;114(10):1587-1592. doi: 
      10.14309/ajg.0000000000000310.