PMID- 31274534
OWN - NLM
STAT- MEDLINE
DCOM- 20200812
LR  - 20210110
IS  - 1473-5571 (Electronic)
IS  - 0269-9370 (Print)
IS  - 0269-9370 (Linking)
VI  - 33
IP  - 12
DP  - 2019 Oct 1
TI  - Height and timing of growth spurt during puberty in young people living with 
      vertically acquired HIV in Europe and Thailand.
PG  - 1897-1910
LID - 10.1097/QAD.0000000000002294 [doi]
AB  - OBJECTIVE: The aim of this study was to describe growth during puberty in young 
      people with vertically acquired HIV. DESIGN: Pooled data from 12 paediatric HIV 
      cohorts in Europe and Thailand. METHODS: One thousand and ninety-four children 
      initiating a nonnucleoside reverse transcriptase inhibitor or boosted protease 
      inhibitor based regimen aged 1-10 years were included. Super Imposition by 
      Translation And Rotation (SITAR) models described growth from age 8 years using 
      three parameters (average height, timing and shape of the growth spurt), 
      dependent on age and height-for-age z-score (HAZ) (WHO references) at 
      antiretroviral therapy (ART) initiation. Multivariate regression explored 
      characteristics associated with these three parameters. RESULTS: At ART 
      initiation, median age and HAZ was 6.4 [interquartile range (IQR): 2.8, 9.0] 
      years and -1.2 (IQR: -2.3 to -0.2), respectively. Median follow-up was 9.1 (IQR: 
      6.9, 11.4) years. In girls, older age and lower HAZ at ART initiation were 
      independently associated with a growth spurt which occurred 0.41 (95% confidence 
      interval 0.20-0.62) years later in children starting ART age 6 to 10 years 
      compared with 1 to 2 years and 1.50 (1.21-1.78) years later in those starting 
      with HAZ less than -3 compared with HAZ at least -1. Later growth spurts in girls 
      resulted in continued height growth into later adolescence. In boys starting ART 
      with HAZ less than -1, growth spurts were later in children starting ART in the 
      oldest age group, but for HAZ at least -1, there was no association with age. 
      Girls and boys who initiated ART with HAZ at least -1 maintained a similar height 
      to the WHO reference mean. CONCLUSION: Stunting at ART initiation was associated 
      with later growth spurts in girls. Children with HAZ at least -1 at ART 
      initiation grew in height at the level expected in HIV negative children of a 
      comparable age.
CN  - European Pregnancy and Paediatric HIV Cohort Collaboration (EPPICC) study group
LA  - eng
GR  - MC_UU_12023/17/MRC_/Medical Research Council/United Kingdom
GR  - MC_UU_12023/26/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - AIDS
JT  - AIDS (London, England)
JID - 8710219
RN  - 0 (Anti-Retroviral Agents)
SB  - IM
MH  - Adolescent
MH  - Anthropometry
MH  - Anti-Retroviral Agents/*therapeutic use
MH  - Child
MH  - *Child Development
MH  - Child, Preschool
MH  - Cohort Studies
MH  - Europe
MH  - Female
MH  - HIV Infections/*drug therapy
MH  - Humans
MH  - Infant
MH  - Male
MH  - *Puberty
MH  - Thailand
PMC - PMC6738540
EDAT- 2019/07/06 06:00
MHDA- 2020/08/13 06:00
PMCR- 2019/09/11
CRDT- 2019/07/06 06:00
PHST- 2019/07/06 06:00 [pubmed]
PHST- 2020/08/13 06:00 [medline]
PHST- 2019/07/06 06:00 [entrez]
PHST- 2019/09/11 00:00 [pmc-release]
AID - AIDS-D-18-01038 [pii]
AID - 10.1097/QAD.0000000000002294 [doi]
PST - ppublish
SO  - AIDS. 2019 Oct 1;33(12):1897-1910. doi: 10.1097/QAD.0000000000002294.