PMID- 31275222
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1664-2295 (Print)
IS  - 1664-2295 (Electronic)
IS  - 1664-2295 (Linking)
VI  - 10
DP  - 2019
TI  - Altered Whole-Brain Functional Topological Organization and Cognitive Function in 
      Type 2 Diabetes Mellitus Patients.
PG  - 599
LID - 10.3389/fneur.2019.00599 [doi]
LID - 599
AB  - Type 2 diabetes mellitus (T2DM) is associated with cognitive dysfunction and may 
      even progress to dementia. However, the underlying mechanism of altered 
      functional topological organization and cognitive impairments remains unclear. 
      This study explored the topological properties of functional whole brain networks 
      in T2DM patients with graph theoretical analysis using a resting-state functional 
      magnetic resonance imaging (rs-fMRI) technique. Thirty T2DM patients (aged 51.77 
      +/- 1.42 years) and 30 sex-, age-, and education-matched healthy controls (HCs) 
      (aged 48.87 +/- 0.98 years) underwent resting-state functional imaging in a 3.0 T 
      MR scanner in addition to detailed neuropsychological and laboratory tests. Then, 
      graph theoretical network analysis was performed to explore the global and nodal 
      topological alterations in the functional whole brain networks of the T2DM 
      patients. Finally, correlation analyses were performed to investigate the 
      relationship between the altered topological parameters, cognitive performances 
      and clinical variables. Compared to HCs, we found that T2DM patients displayed 
      worse performances in general cognitive function and several cognitive domains, 
      including episodic memory, attention and executive function. In addition, T2DM 
      patients showed a higher small-worldness (sigma), a higher normalized clustering 
      coefficient (gamma) and a higher local efficiency (E(loc)). Moreover, decreased nodal 
      topological properties were mainly distributed in the occipital lobes, frontal 
      lobes, left median cingulate and paracingulate gyri, and left amygdala, while 
      increased nodal topological properties were mainly distributed in the right gyrus 
      rectus, right anterior cingulate and paracingulate gyri, right posterior 
      cingulate gyrus, bilateral caudate nucleus, bilateral cerebellum 3, bilateral 
      cerebellum crus 1, vermis (1, 2) and vermis 3. Some disrupted nodal topological 
      properties were correlated with cognitive performance and HbA1c levels in T2DM 
      patients. This study shows altered functional topological organization in T2DM 
      patients, mainly suggesting a compensation mechanism of the functional whole 
      brain network in the relatively early stage to counteract cognitive impairments.
FAU - Qin, Chunhong
AU  - Qin C
AD  - Department of Radiology, First Affiliated Hospital of Guangzhou University of 
      Chinese Medicine, Guangzhou, China.
FAU - Liang, Yi
AU  - Liang Y
AD  - Department of Radiology, First Affiliated Hospital of Guangzhou University of 
      Chinese Medicine, Guangzhou, China.
FAU - Tan, Xin
AU  - Tan X
AD  - Department of Radiology, First Affiliated Hospital of Guangzhou University of 
      Chinese Medicine, Guangzhou, China.
FAU - Leng, Xi
AU  - Leng X
AD  - Department of Radiology, First Affiliated Hospital of Guangzhou University of 
      Chinese Medicine, Guangzhou, China.
FAU - Lin, Huan
AU  - Lin H
AD  - Department of Radiology, Zhujiang Hospital of Southern Medical University, 
      Guangzhou, China.
FAU - Zeng, Hui
AU  - Zeng H
AD  - Guangzhou University of Chinese Medicine, Guangzhou, China.
FAU - Zhang, Chi
AU  - Zhang C
AD  - Department of Radiology, First Affiliated Hospital of Guangzhou University of 
      Chinese Medicine, Guangzhou, China.
FAU - Yang, Jinquan
AU  - Yang J
AD  - Guangzhou University of Chinese Medicine, Guangzhou, China.
FAU - Li, Yifan
AU  - Li Y
AD  - Guangzhou University of Chinese Medicine, Guangzhou, China.
FAU - Zheng, Yanting
AU  - Zheng Y
AD  - Guangzhou University of Chinese Medicine, Guangzhou, China.
FAU - Qiu, Shijun
AU  - Qiu S
AD  - Department of Radiology, First Affiliated Hospital of Guangzhou University of 
      Chinese Medicine, Guangzhou, China.
AD  - Guangzhou University of Chinese Medicine, Guangzhou, China.
LA  - eng
GR  - R01 AG041721/AG/NIA NIH HHS/United States
PT  - Journal Article
DEP - 20190605
PL  - Switzerland
TA  - Front Neurol
JT  - Frontiers in neurology
JID - 101546899
PMC - PMC6593281
OTO - NOTNLM
OT  - cognitive function
OT  - graph theoretical analysis
OT  - resting-state functional magnetic resonance imaging
OT  - topological organization
OT  - type 2 diabetes mellitus
EDAT- 2019/07/06 06:00
MHDA- 2019/07/06 06:01
PMCR- 2019/06/05
CRDT- 2019/07/06 06:00
PHST- 2019/02/02 00:00 [received]
PHST- 2019/05/21 00:00 [accepted]
PHST- 2019/07/06 06:00 [entrez]
PHST- 2019/07/06 06:00 [pubmed]
PHST- 2019/07/06 06:01 [medline]
PHST- 2019/06/05 00:00 [pmc-release]
AID - 10.3389/fneur.2019.00599 [doi]
PST - epublish
SO  - Front Neurol. 2019 Jun 5;10:599. doi: 10.3389/fneur.2019.00599. eCollection 2019.