PMID- 31275359
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231012
IS  - 1664-8021 (Print)
IS  - 1664-8021 (Electronic)
IS  - 1664-8021 (Linking)
VI  - 10
DP  - 2019
TI  - Chromosomal Localization of Candidate Genes for Fiber Growth and Color in Alpaca 
      (Vicugna pacos).
PG  - 583
LID - 10.3389/fgene.2019.00583 [doi]
LID - 583
AB  - The alpaca (Vicugna pacos) is an economically important and cultural signature 
      species in Peru. Thus, molecular genomic information about the genes underlying 
      the traits of interest, such as fiber properties and color, is critical for 
      improved breeding and management schemes. Current knowledge about the alpaca 
      genome, particularly the chromosomal location of such genes of interest is 
      limited and lags far behind other livestock species. The main objective of this 
      work was to localize alpaca candidate genes for fiber growth and color using 
      fluorescence in situ hybridization (FISH). We report the mapping of candidate 
      genes for fiber growth COL1A1, CTNNB1, DAB2IP, KRT15, KRTAP13-1, and TNFSF12 to 
      chromosomes 16, 17, 4, 16, 1, and 16, respectively. Likewise, we report the 
      mapping of candidate genes for fiber color ALX3, NCOA6, SOX9, ZIC1, and ZIC5 to 
      chromosomes 9, 19, 16, 1, and 14, respectively. In addition, since KRT15 clusters 
      with five other keratin genes (KRT31, KRT13, KRT9, KRT14, and KRT16) in scaffold 
      450 (Vic.Pac 2.0.2), the entire gene cluster was assigned to chromosome 16. 
      Similarly, mapping NCOA6 to chromosome 19, anchored scaffold 34 with 8 genes, 
      viz., RALY, EIF2S2, XPOTP1, ASIP, AHCY, ITCH, PIGU, and GGT7 to chromosome 19. 
      These results are concordant with known conserved synteny blocks between camelids 
      and humans, cattle and pigs.
FAU - Mendoza, Mayra N
AU  - Mendoza MN
AD  - Programa de Mejoramiento Animal, Universidad Nacional Agraria La Molina, Lima, 
      Peru.
FAU - Raudsepp, Terje
AU  - Raudsepp T
AD  - Molecular Cytogenetics and Genomics Laboratory, Texas A&M University, College 
      Station, TX, United States.
FAU - Alshanbari, Fahad
AU  - Alshanbari F
AD  - Molecular Cytogenetics and Genomics Laboratory, Texas A&M University, College 
      Station, TX, United States.
FAU - Gutierrez, Gustavo
AU  - Gutierrez G
AD  - Programa de Mejoramiento Animal, Universidad Nacional Agraria La Molina, Lima, 
      Peru.
FAU - Ponce de Leon, F Abel
AU  - Ponce de Leon FA
AD  - Department of Animal Science, University of Minnesota, Minneapolis, MN, United 
      States.
LA  - eng
PT  - Journal Article
DEP - 20190619
PL  - Switzerland
TA  - Front Genet
JT  - Frontiers in genetics
JID - 101560621
PMC - PMC6593342
OTO - NOTNLM
OT  - FISH
OT  - alpaca
OT  - chromosomes
OT  - color
OT  - fiber
OT  - genes
OT  - mapping
EDAT- 2019/07/06 06:00
MHDA- 2019/07/06 06:01
PMCR- 2019/06/19
CRDT- 2019/07/06 06:00
PHST- 2018/10/29 00:00 [received]
PHST- 2019/06/04 00:00 [accepted]
PHST- 2019/07/06 06:00 [entrez]
PHST- 2019/07/06 06:00 [pubmed]
PHST- 2019/07/06 06:01 [medline]
PHST- 2019/06/19 00:00 [pmc-release]
AID - 10.3389/fgene.2019.00583 [doi]
PST - epublish
SO  - Front Genet. 2019 Jun 19;10:583. doi: 10.3389/fgene.2019.00583. eCollection 2019.