PMID- 31275473
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1881-641X (Print)
IS  - 1881-6428 (Electronic)
IS  - 1881-641X (Linking)
VI  - 12
IP  - 2
DP  - 2019 Jun 25
TI  - Sarcopenia as a Possible Negative Predictor of Limb Salvage in Patients with 
      Chronic Limb-Threatening Ischemia.
PG  - 194-199
LID - 10.3400/avd.oa.18-00167 [doi]
AB  - Objective: Open revascularization of the lower extremity in patients with chronic 
      limb-threatening ischemia (CLTI) does not guarantee limb salvage. Due to the high 
      prevalence of frailty among these patients, we hypothesized that sarcopenia 
      negatively affects limb prognosis. Methods: Seventy-five CLTI patients who 
      underwent open revascularization between 2011 and 2015 were retrospectively 
      reviewed. The lumbar psoas index, which is the ratio of the cross-sectional area 
      of the psoas major muscles to the patients' height squared, was used as a 
      surrogate marker for sarcopenia. Male and female patients were stratified 
      separately according to lumbar psoas index values. The lower two-thirds of the 
      population for each sex were defined as the sarcopenia group, with the higher 
      third defined as the non-sarcopenia group. Results: Comorbidities and ambulatory 
      status did not differ between the sarcopenia (n=50) and non-sarcopenia (n=25) 
      groups. The sarcopenia group had significantly lower overall survival rates than 
      the non-sarcopenia group (60% vs 87% at 3 years, P<0.05). Moreover, the limb 
      salvage rates were significantly lower in the sarcopenia group than in the 
      non-sarcopenia group (73% vs 100% at 2 years, P<0.05). Conclusion: Sarcopenia, as 
      measured by the lumbar psoas index, may predict poor limb prognosis in CLTI 
      patients undergoing open revascularization.
FAU - Taniguchi, Ryosuke
AU  - Taniguchi R
AD  - Department of Vascular Surgery, Saitama Medical Center, Saitama Medical 
      University, Kawagoe, Saitama, Japan.
FAU - Deguchi, Juno
AU  - Deguchi J
AD  - Department of Vascular Surgery, Saitama Medical Center, Saitama Medical 
      University, Kawagoe, Saitama, Japan.
FAU - Hashimoto, Takuya
AU  - Hashimoto T
AD  - Department of Vascular Surgery, Saitama Medical Center, Saitama Medical 
      University, Kawagoe, Saitama, Japan.
FAU - Sato, Osamu
AU  - Sato O
AD  - Department of Vascular Surgery, Saitama Medical Center, Saitama Medical 
      University, Kawagoe, Saitama, Japan.
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Ann Vasc Dis
JT  - Annals of vascular diseases
JID - 101471467
PMC - PMC6600098
OTO - NOTNLM
OT  - chronic limb-threatening ischemia (CLTI)
OT  - frailty
OT  - limb salvage
OT  - psoas major muscle
OT  - sarcopenia
COIS- Disclosure StatementAll authors have no conflict of interest.
EDAT- 2019/07/06 06:00
MHDA- 2019/07/06 06:01
PMCR- 2019/06/25
CRDT- 2019/07/06 06:00
PHST- 2019/07/06 06:00 [entrez]
PHST- 2019/07/06 06:00 [pubmed]
PHST- 2019/07/06 06:01 [medline]
PHST- 2019/06/25 00:00 [pmc-release]
AID - 10.3400/avd.oa.18-00167 [doi]
PST - ppublish
SO  - Ann Vasc Dis. 2019 Jun 25;12(2):194-199. doi: 10.3400/avd.oa.18-00167.