PMID- 31275768
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2168-8184 (Print)
IS  - 2168-8184 (Electronic)
IS  - 2168-8184 (Linking)
VI  - 11
IP  - 4
DP  - 2019 Apr 25
TI  - Granular Cell Pituitary Tumor in a Patient with Multiple Endocrine Neoplasia-1.
PG  - e4541
LID - 10.7759/cureus.4541 [doi]
LID - e4541
AB  - Multiple endocrine neoplasia type 1 (MEN-1) is an autosomal dominant disorder 
      characterized by parathyroid, pancreatic islet, and pituitary tumors. 
      Approximately 40% of MEN-1 patients harbor a pituitary adenoma. Separately, 
      granular cell tumors (GCTs) of the sellar/parasellar region are an exceedingly 
      rare clinical entity with less than 100 reported cases in the literature. These 
      slow-growing, often asymptomatic lesions are difficult to diagnose and may mimic 
      pituitary adenoma, Rathke cleft cyst, or other sellar/supra-sellar pathology. 
      There is no known association with MEN-1 or any other familial syndrome. A 
      36-year-old neurologically normal woman with known MEN-1 underwent a screening 
      magnetic resonance imaging (MRI) scan which revealed a 10 mm x 6 mm x 7 mm 
      sellar/suprasellar lesion. She underwent endoscopic endonasal transsphenoidal 
      resection. Subsequent neuropathological analysis was consistent with GCT of the 
      pituitary gland. Here we describe the first report to our knowledge of a GCT of 
      the pituitary gland occurring in a patient with MEN-1.
FAU - Pendharkar, Arjun V
AU  - Pendharkar AV
AD  - Neurosurgery, Stanford University School of Medicine, Stanford, USA.
FAU - Lin, Chieh-Yu
AU  - Lin CY
AD  - Pathology & Immunology, Washington University in St. Louis, St. Louis, USA.
FAU - Born, Donald E
AU  - Born DE
AD  - Pathology, Stanford University School of Medicine, Stanford, USA.
FAU - Hoffman, Andrew R
AU  - Hoffman AR
AD  - Internal Medicine - Diabetes & Endocrinology, Stanford University School of 
      Medicine, Stanford, USA.
FAU - Dodd, Robert L
AU  - Dodd RL
AD  - Neurosurgery, Stanford University School of Medicine, Stanford, USA.
LA  - eng
PT  - Case Reports
DEP - 20190425
PL  - United States
TA  - Cureus
JT  - Cureus
JID - 101596737
PMC - PMC6592835
OTO - NOTNLM
OT  - granular cell tumor
OT  - men-1
OT  - multiple endocrine neoplasia type 1
OT  - pituitary tumor
COIS- The authors have declared that no competing interests exist.
EDAT- 2019/07/06 06:00
MHDA- 2019/07/06 06:01
PMCR- 2019/04/25
CRDT- 2019/07/06 06:00
PHST- 2019/07/06 06:00 [entrez]
PHST- 2019/07/06 06:00 [pubmed]
PHST- 2019/07/06 06:01 [medline]
PHST- 2019/04/25 00:00 [pmc-release]
AID - 10.7759/cureus.4541 [doi]
PST - epublish
SO  - Cureus. 2019 Apr 25;11(4):e4541. doi: 10.7759/cureus.4541.