PMID- 31276494
OWN - NLM
STAT- MEDLINE
DCOM- 20200106
LR  - 20200309
IS  - 1935-2735 (Electronic)
IS  - 1935-2727 (Print)
IS  - 1935-2727 (Linking)
VI  - 13
IP  - 7
DP  - 2019 Jul
TI  - Improved assessment of mass drug administration and health district management 
      performance to eliminate lymphatic filariasis.
PG  - e0007337
LID - 10.1371/journal.pntd.0007337 [doi]
LID - e0007337
AB  - Lymphatic filariasis (LF) elimination as a public health problem requires the 
      interruption of transmission by administration of preventive mass drug 
      administration (MDA) to the eligible population living in endemic districts. 
      Suboptimal MDA coverage leads to persistent parasite transmission with 
      consequential infection, disease and disability, and the need for continuing MDA 
      rounds, requiring considerable investment. Routine coverage reports must be 
      verified in each MDA implementation unit (IU) due to incorrect denominators and 
      numerators used to calculate coverage estimates with administrative data. IU are 
      usually the health districts. Coverage is verified so IU teams can evaluate their 
      outreach and take appropriate action to improve performance. Mozambique and the 
      Democratic Republic of Congo (DRC) have conducted MDA campaigns for LF since 2009 
      and 2014, respectively. To verify district reports and assess the declared 
      achievement using administrative data of the minimum 80% coverage of eligible 
      people (or 65% of the total population), both countries conducted rapid 
      probability surveys using Lot Quality Assurance Sampling (LQAS)(n = 1102) in 2015 
      and 2016 in 58 IU in 49 districts. The surveys identified IU with suboptimal 
      coverage, reasons residents did not take the medication, place where the 
      medication was received, information sources, and knowledge about diseases 
      prevented by the MDA. LQAS identified four inadequately covered IU triggering 
      district team performance reviews with provincial and national teams and district 
      retreatment. Provincial estimates using probability samples (weighted by 
      populations sizes) were 10 and 17 percentage points lower than reported coverage 
      in DRC and Mozambique. The surveys identified: absence from home during annual 
      MDA rounds as the main reason for low performance and provided valuable 
      information about pre-campaign and campaign activities resulting in improved 
      strategies and continued progress towards elimination of LF and co-endemic 
      Neglected Tropical Diseases.
FAU - Maroto-Camino, Carmen
AU  - Maroto-Camino C
AD  - Department of International Health, Liverpool School of Tropical Medicine, 
      Liverpool, United Kingdom.
FAU - Hernandez-Pastor, Pilar
AU  - Hernandez-Pastor P
AD  - Department of International Health, Liverpool School of Tropical Medicine, 
      Liverpool, United Kingdom.
FAU - Awaca, Naomi
AU  - Awaca N
AD  - National NTD Programme, Democratic Republic of Congo, Ministere de la Sante 
      Publique, Gombe, Kinshasa.
FAU - Safari, Lebon
AU  - Safari L
AD  - Department of International Health, Liverpool School of Tropical Medicine, 
      Liverpool, United Kingdom.
FAU - Hemingway, Janet
AU  - Hemingway J
AD  - Department of International Health, Liverpool School of Tropical Medicine, 
      Liverpool, United Kingdom.
FAU - Massangaie, Marilia
AU  - Massangaie M
AD  - National NTD Programme, Direcao Nacional da Saude Publica, Ministerio da Saude, 
      Eduardo Modliane, Maputo, Mozambique.
FAU - Whitson, Donald
AU  - Whitson D
AD  - Department of International Health, Liverpool School of Tropical Medicine, 
      Liverpool, United Kingdom.
FAU - Jeffery, Caroline
AU  - Jeffery C
AD  - Department of International Health, Liverpool School of Tropical Medicine, 
      Liverpool, United Kingdom.
FAU - Valadez, Joseph J
AU  - Valadez JJ
AUID- ORCID: 0000-0002-6575-6592
AD  - Department of International Health, Liverpool School of Tropical Medicine, 
      Liverpool, United Kingdom.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190705
PL  - United States
TA  - PLoS Negl Trop Dis
JT  - PLoS neglected tropical diseases
JID - 101291488
RN  - 0 (Filaricides)
SB  - IM
MH  - Animals
MH  - Democratic Republic of the Congo/epidemiology
MH  - Disease Eradication/methods/*standards
MH  - Elephantiasis, Filarial/*prevention & control
MH  - Endemic Diseases/prevention & control
MH  - Filaricides/*administration & dosage
MH  - Humans
MH  - Mass Drug Administration/*standards
MH  - Mozambique/epidemiology
MH  - Neglected Diseases/epidemiology/prevention & control
MH  - *Outcome and Process Assessment, Health Care
MH  - Public Health
MH  - *Quality Assurance, Health Care
MH  - Wuchereria bancrofti/drug effects
PMC - PMC6636779
COIS- The authors have declared that no competing interests exist.
EDAT- 2019/07/06 06:00
MHDA- 2020/01/07 06:00
PMCR- 2019/07/05
CRDT- 2019/07/06 06:00
PHST- 2018/10/04 00:00 [received]
PHST- 2019/03/27 00:00 [accepted]
PHST- 2019/07/17 00:00 [revised]
PHST- 2019/07/06 06:00 [pubmed]
PHST- 2020/01/07 06:00 [medline]
PHST- 2019/07/06 06:00 [entrez]
PHST- 2019/07/05 00:00 [pmc-release]
AID - PNTD-D-18-01534 [pii]
AID - 10.1371/journal.pntd.0007337 [doi]
PST - epublish
SO  - PLoS Negl Trop Dis. 2019 Jul 5;13(7):e0007337. doi: 10.1371/journal.pntd.0007337. 
      eCollection 2019 Jul.