PMID- 31276632
OWN - NLM
STAT- MEDLINE
DCOM- 20191230
LR  - 20191230
IS  - 1873-3492 (Electronic)
IS  - 0009-8981 (Linking)
VI  - 496
DP  - 2019 Sep
TI  - Inflammatory markers in children and adolescents with type 2 diabetes mellitus.
PG  - 100-107
LID - S0009-8981(19)31943-6 [pii]
LID - 10.1016/j.cca.2019.07.006 [doi]
AB  - This review examines the potential relationship between serum inflammation 
      markers and type 2 diabetes mellitus (T2DM). Inflammation markers have been 
      proposed as prognostic markers for the development of T2DM and its complications. 
      Furthermore, modulation of the inflammatory process may offer future treatment 
      strategies for T2DM. This review focuses on children and adolescents because 
      there is usually little, if any, complications associated with other disease 
      processes, use of medications, or active tobacco smoking. Furthermore, beta-cell 
      failure in young age cannot be solely explained by aging and exhaustion of 
      beta-cells due to insulin resistance. Pediatric studies have demonstrated that 
      pro-inflammatory cytokines TNF-alpha, IL-6, IL-1beta, IFNgamma, PEDF, and fetuin A were 
      increased in insulin resistance, while the anti-inflammatory cytokines 
      adiponectin and omentin were decreased. Furthermore, TNF-alpha, fetuin A, FGF-21 were 
      altered in obese children with T2DM suggesting a direct involvement in beta-cell 
      failure. Future studies focusing on children and adolescents may facilitate our 
      understanding of T2DM as an inflammatory disease process.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Reinehr, Thomas
AU  - Reinehr T
AD  - Department of Pediatric Endocrinology, Diabetes and Nutrition Medicine, Vestische 
      Hospital for Children and Adolescents Datteln, University of Witten/Herdecke, Dr. 
      F. Steiner Str. 5, D-45711 Datteln, Germany. Electronic address: 
      T.Reinehr@kinderklinik-datteln.de.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20190702
PL  - Netherlands
TA  - Clin Chim Acta
JT  - Clinica chimica acta; international journal of clinical chemistry
JID - 1302422
RN  - 0 (Biomarkers)
SB  - IM
MH  - Adolescent
MH  - Biomarkers/*metabolism
MH  - Child
MH  - Diabetes Mellitus, Type 2/*metabolism
MH  - Humans
MH  - Inflammation/metabolism
MH  - Insulin Resistance
MH  - Insulin Secretion
OTO - NOTNLM
OT  - Adipokines
OT  - Children
OT  - Diabetes mellitus type 2
OT  - Heptokines
OT  - Inflammation
EDAT- 2019/07/06 06:00
MHDA- 2019/12/31 06:00
CRDT- 2019/07/06 06:00
PHST- 2019/06/18 00:00 [received]
PHST- 2019/06/24 00:00 [revised]
PHST- 2019/07/01 00:00 [accepted]
PHST- 2019/07/06 06:00 [pubmed]
PHST- 2019/12/31 06:00 [medline]
PHST- 2019/07/06 06:00 [entrez]
AID - S0009-8981(19)31943-6 [pii]
AID - 10.1016/j.cca.2019.07.006 [doi]
PST - ppublish
SO  - Clin Chim Acta. 2019 Sep;496:100-107. doi: 10.1016/j.cca.2019.07.006. Epub 2019 
      Jul 2.