PMID- 31278873
OWN - NLM
STAT- MEDLINE
DCOM- 20200911
LR  - 20231111
IS  - 1521-3773 (Electronic)
IS  - 1433-7851 (Print)
IS  - 1433-7851 (Linking)
VI  - 58
IP  - 35
DP  - 2019 Aug 26
TI  - Correlating Anticancer Drug Delivery Efficiency with Vascular Permeability of 
      Renal Clearable Versus Non-renal Clearable Nanocarriers.
PG  - 12076-12080
LID - 10.1002/anie.201905738 [doi]
AB  - Enhancing tumor targeting of nanocarriers has been a major strategy for advancing 
      clinical translation of cancer nanomedicines. Herein, we report a head-to-head 
      comparison between 5 nm renal clearable and 30 nm non-renal clearable gold 
      nanoparticle (AuNP)-based drug delivery systems (DDSs) in the delivery of 
      doxorubicin (DOX). While the two DDSs themselves had comparable tumor targeting, 
      we found their different vascular permeability played an even more important role 
      than blood retention in the delivery and intratumoral transport of DOX, of which 
      tumor accumulation, efficacy, and therapeutic index were enhanced 2, 7, and 
      10-fold, respectively, for the 5 nm DDS over 30 nm one. These findings indicate 
      that ultrahigh vascular permeability of renal clearable nanocarriers can be 
      utilized to further improve anticancer drug delivery without the need for 
      prolonged blood retention.
CI  - (c) 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
FAU - Peng, Chuanqi
AU  - Peng C
AD  - Department of Chemistry and Biochemistry, The University of Texas at Dallas, 800 
      W. Campbell Rd., Richardson, TX, 75080, USA.
FAU - Yu, Mengxiao
AU  - Yu M
AD  - Department of Chemistry and Biochemistry, The University of Texas at Dallas, 800 
      W. Campbell Rd., Richardson, TX, 75080, USA.
FAU - Hsieh, Jer-Tsong
AU  - Hsieh JT
AD  - Department of Urology, The University of Texas Southwestern Medical Center, 5323 
      Harry Hines Blvd., Dallas, TX, 75390, USA.
FAU - Kapur, Payal
AU  - Kapur P
AD  - Department of Urology, The University of Texas Southwestern Medical Center, 5323 
      Harry Hines Blvd., Dallas, TX, 75390, USA.
AD  - Department of Pathology, The University of Texas Southwestern Medical Center, 
      5323 Harry Hines Blvd., Dallas, TX, 75390, USA.
FAU - Zheng, Jie
AU  - Zheng J
AUID- ORCID: 0000-0001-8546-1882
AD  - Department of Chemistry and Biochemistry, The University of Texas at Dallas, 800 
      W. Campbell Rd., Richardson, TX, 75080, USA.
AD  - Department of Urology, The University of Texas Southwestern Medical Center, 5323 
      Harry Hines Blvd., Dallas, TX, 75390, USA.
LA  - eng
GR  - R01 DK103363/DK/NIDDK NIH HHS/United States
GR  - RP160866/CPRIT/International
GR  - AT-1974-20180324/Welch Foundation/International
GR  - 1R01DK103363/NIH NIDDK/International
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20190724
PL  - Germany
TA  - Angew Chem Int Ed Engl
JT  - Angewandte Chemie (International ed. in English)
JID - 0370543
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Drug Carriers)
RN  - 7440-57-5 (Gold)
RN  - 80168379AG (Doxorubicin)
SB  - IM
MH  - Animals
MH  - Antineoplastic Agents/*chemistry/metabolism/therapeutic use
MH  - Capillary Permeability
MH  - Doxorubicin/chemistry/metabolism/therapeutic use
MH  - Drug Carriers/*chemistry
MH  - Gold/chemistry
MH  - Humans
MH  - Hydrodynamics
MH  - Kidney/metabolism
MH  - MCF-7 Cells
MH  - Metal Nanoparticles/*chemistry
MH  - Mice
MH  - Microscopy, Confocal
MH  - Neoplasms/drug therapy/pathology
MH  - Particle Size
MH  - Tissue Distribution
PMC - PMC7416736
MID - NIHMS1040956
OTO - NOTNLM
OT  - drug delivery
OT  - gold nanoparticles
OT  - intratumoral transport
OT  - therapeutic index
OT  - vascular permeability
COIS- Conflict of interest The authors declare no conflict of interests.
EDAT- 2019/07/07 06:00
MHDA- 2020/09/12 06:00
PMCR- 2020/08/26
CRDT- 2019/07/07 06:00
PHST- 2019/05/08 00:00 [received]
PHST- 2019/07/03 00:00 [revised]
PHST- 2019/07/07 06:00 [pubmed]
PHST- 2020/09/12 06:00 [medline]
PHST- 2019/07/07 06:00 [entrez]
PHST- 2020/08/26 00:00 [pmc-release]
AID - 10.1002/anie.201905738 [doi]
PST - ppublish
SO  - Angew Chem Int Ed Engl. 2019 Aug 26;58(35):12076-12080. doi: 
      10.1002/anie.201905738. Epub 2019 Jul 24.