PMID- 31279093 OWN - NLM STAT- MEDLINE DCOM- 20200611 LR - 20200611 IS - 1872-8421 (Electronic) IS - 0165-5728 (Linking) VI - 334 DP - 2019 Sep 15 TI - Two Japanese cases of anti-MOG antibody-associated encephalitis that mimicked neuro-Behcet's disease. PG - 577002 LID - S0165-5728(19)30271-1 [pii] LID - 10.1016/j.jneuroim.2019.577002 [doi] AB - Recently, we documented two Japanese cases of myelin-oligodendrocyte glycoprotein (MOG) antibody-associated relapsing encephalitis among patients who had been diagnosed with probable neuro-Behcet's disease (NBD). They presented partial systemic BD symptoms, brainstem lesions, and the human leukocyte antigen (HLA) B51 allele and responded well to steroid therapy. Our cases suggest that we need to differentiate anti-MOG antibody-associated encephalitis from probable NBD because both disorders can present with brainstem or cerebral lesions, CSF pleocytosis, and elevated levels of CSF IL-6 and respond to steroid treatment. Furthermore, oral ulceration, skin lesions, and HLA-B51 might be observed nonspecifically in patients with anti-MOG antibody-associated encephalitis. CI - Copyright (c) 2019 Elsevier B.V. All rights reserved. FAU - Fujimori, Juichi AU - Fujimori J AD - Department of Neurology, Tohoku Medical and Pharmaceutical University, Sendai, Japan. Electronic address: j-fujimori@tohoku-mpu.ac.jp. FAU - Takahashi, Toshiyuki AU - Takahashi T AD - Department of Neurology, Tohoku University Graduate School of Medicine, Sendai, Japan; Department of Neurology, National Hospital Organization Yonezawa National Hospital, Yonezawa, Japan. FAU - Matsumoto, Yuki AU - Matsumoto Y AD - Department of Neurology, Tohoku University Graduate School of Medicine, Sendai, Japan. FAU - Fujihara, Kazuo AU - Fujihara K AD - Department of Multiple Sclerosis Therapeutics, Tohoku University Graduate School of Medicine, Sendai, Japan; Department of Multiple Sclerosis Therapeutics, Fukushima Medical University, School of Medicine and Multiple Sclerosis, Neuromyelitis Optica Center, Southern Tohoku Research Institute for Neuroscience, Koriyama, Japan. FAU - Takai, Yoshiki AU - Takai Y AD - Department of Neurology, Tohoku University Graduate School of Medicine, Sendai, Japan. FAU - Misu, Tatsuro AU - Misu T AD - Department of Multiple Sclerosis Therapeutics, Tohoku University Graduate School of Medicine, Sendai, Japan. FAU - Nakashima, Ichiro AU - Nakashima I AD - Department of Neurology, Tohoku Medical and Pharmaceutical University, Sendai, Japan. LA - eng PT - Case Reports PT - Journal Article DEP - 20190629 PL - Netherlands TA - J Neuroimmunol JT - Journal of neuroimmunology JID - 8109498 RN - 0 (MOG protein, human) RN - 0 (Myelin-Oligodendrocyte Glycoprotein) SB - IM MH - Adult MH - Behcet Syndrome/*cerebrospinal fluid/*diagnostic imaging MH - Encephalitis/*cerebrospinal fluid/*diagnostic imaging MH - Female MH - Humans MH - Japan MH - Male MH - Middle Aged MH - Myelin-Oligodendrocyte Glycoprotein/*cerebrospinal fluid OTO - NOTNLM OT - Differential diagnosis OT - Encephalitis OT - Myelin-oligodendrocyte glycoprotein OT - Neuro-Behcet's disease EDAT- 2019/07/07 06:00 MHDA- 2020/06/12 06:00 CRDT- 2019/07/07 06:00 PHST- 2019/05/31 00:00 [received] PHST- 2019/06/17 00:00 [revised] PHST- 2019/06/27 00:00 [accepted] PHST- 2019/07/07 06:00 [pubmed] PHST- 2020/06/12 06:00 [medline] PHST- 2019/07/07 06:00 [entrez] AID - S0165-5728(19)30271-1 [pii] AID - 10.1016/j.jneuroim.2019.577002 [doi] PST - ppublish SO - J Neuroimmunol. 2019 Sep 15;334:577002. doi: 10.1016/j.jneuroim.2019.577002. Epub 2019 Jun 29.