PMID- 31279327 OWN - NLM STAT- MEDLINE DCOM- 20200316 LR - 20200316 IS - 2567-6911 (Electronic) IS - 0932-0814 (Linking) VI - 32 IP - 6 DP - 2019 Nov TI - Evaluation of a Novel Bone Substitute Injection Technique for Potential Treatment of Impact Injury to the Equine Palmar Metacarpal Condyle. PG - 447-453 LID - 10.1055/s-0039-1692984 [doi] AB - OBJECTIVE: The aim of this study was to evaluate the injection of a bone substitute material (BSM) into an impact lesion in the palmar condyle of the third metacarpal bone. STUDY DESIGN: This was an in vivo controlled study performed on six horses. MATERIALS AND METHODS: Medial metacarpal condyles were exposed via arthrotomy and a compressive lesion created in anaesthetized horses using 80 psi (27.6 MPa) onto the articular surface (n = 12). Paired limbs were randomly selected as a control or for extra-articular injection of BSM towards the subchondral bone near the compressive lesion. Parameters of the surgical techniques and BSM distribution outcomes were evaluated using magnetic resonance imaging analysis, histology and histomorphometry. RESULTS: Injection of the BSM required significant pressure, as well as the use of a pilot hole. The BSM was visible in all magnetic resonance imagings in treatment limbs. Post-impact treatment limbs had greater average grey scale values than controls (p = 0.041), and greater average grey scale values than pre-impact treatment limbs (p = 0.004). Histology demonstrated haemorrhage and microfractures at the site of compression with no evidence of bone disruption from BSM injection. CONCLUSION: Injection of BSM into the dense subchondral bone of the equine palmar condyle could be targeted to a site of injury, distributed subchondrally and without further injury to bone or cartilage. CLINICAL SIGNIFICANCE: This procedure has potential for the treatment of clinical impact injury or osteoarthritis in horses, and long-term studies are warranted. CI - Georg Thieme Verlag KG Stuttgart . New York. FAU - Rice, Hilary C AU - Rice HC AD - Department of Veterinary Clinical Sciences, The Ohio State University, Columbus, Ohio, United States. FAU - Brokken, Matthew T AU - Brokken MT AD - Department of Veterinary Clinical Sciences, The Ohio State University, Columbus, Ohio, United States. FAU - Hostnik, Eric T AU - Hostnik ET AD - Department of Veterinary Clinical Sciences, The Ohio State University, Columbus, Ohio, United States. FAU - Bertone, Alicia L AU - Bertone AL AD - Department of Veterinary Clinical Sciences, The Ohio State University, Columbus, Ohio, United States. LA - eng PT - Evaluation Study PT - Journal Article DEP - 20190706 PL - Germany TA - Vet Comp Orthop Traumatol JT - Veterinary and comparative orthopaedics and traumatology : V.C.O.T JID - 8906319 RN - 0 (Bone Substitutes) SB - IM MH - Animals MH - Bone Substitutes/*administration & dosage MH - Cadaver MH - Horses/*injuries MH - Injections, Intralesional/veterinary MH - Magnetic Resonance Imaging/veterinary MH - Metacarpal Bones/diagnostic imaging/*injuries COIS- None declare. EDAT- 2019/07/07 06:00 MHDA- 2020/03/17 06:00 CRDT- 2019/07/07 06:00 PHST- 2019/07/07 06:00 [pubmed] PHST- 2020/03/17 06:00 [medline] PHST- 2019/07/07 06:00 [entrez] AID - 10.1055/s-0039-1692984 [doi] PST - ppublish SO - Vet Comp Orthop Traumatol. 2019 Nov;32(6):447-453. doi: 10.1055/s-0039-1692984. Epub 2019 Jul 6.