PMID- 31280095
OWN - NLM
STAT- MEDLINE
DCOM- 20191017
LR  - 20191017
IS  - 1090-2414 (Electronic)
IS  - 0147-6513 (Linking)
VI  - 182
DP  - 2019 Oct 30
TI  - A review of sources, multimedia distribution and health risks of novel 
      fluorinated alternatives.
PG  - 109402
LID - S0147-6513(19)30732-8 [pii]
LID - 10.1016/j.ecoenv.2019.109402 [doi]
AB  - Per- and polyfluoroalkyl substances (PFASs) are a class of emerging persistent 
      organic pollutants (POPs). They are widely used in industrial and consumer 
      applications. Due to their persistence, bioaccumulation, long-distance migration 
      and toxicity, it is important to find new compounds that can replace PFASs. The 
      present review investigated the sources, fates and environmental effects of 
      alternative PFAS compounds using surveys have been conducted over the past 
      several years. Concentrations of PFAS alternatives in various environmental 
      media, as well as human tissues, are summarized based on the available data. The 
      results showed that hexafluoropropylene oxide dimer (HFPO-DA), 
      hexafluoropropylene trimer acids (HFPO-TA), and 6:2 chlorinated polyfluorinated 
      ether sulfonic acid (6:2 Cl-PFESA) have become the dominant global perfluorinated 
      pollutants. Currently, there are a few toxicity assessments of these novel 
      fluorinated alternatives, showing that they have systemic multiple organ 
      toxicities. PFAS alternatives exhibited comparable or even more serious potential 
      toxicity than legacy PFASs, indicating that these fluorinated alternatives are 
      also harmful to the environment. Therefore, these alternatives require additional 
      toxicological studies to confirm whether they can be used for a long time.
CI  - Copyright (c) 2019 Elsevier Inc. All rights reserved.
FAU - Wang, Yu
AU  - Wang Y
AD  - Institute for Translational Medicine, Qingdao University, Qing Dao, 266071, 
      China. Electronic address: wy-986@163.com.
FAU - Chang, Wenguang
AU  - Chang W
AD  - Institute for Translational Medicine, Qingdao University, Qing Dao, 266071, 
      China.
FAU - Wang, Ling
AU  - Wang L
AD  - Institute of Environment and Health, Jianghan University, Wu Han, 430056, China.
FAU - Zhang, Yinfeng
AU  - Zhang Y
AD  - Institute for Translational Medicine, Qingdao University, Qing Dao, 266071, 
      China.
FAU - Zhang, Yuan
AU  - Zhang Y
AD  - Institute for Translational Medicine, Qingdao University, Qing Dao, 266071, 
      China.
FAU - Wang, Man
AU  - Wang M
AD  - Institute for Translational Medicine, Qingdao University, Qing Dao, 266071, 
      China.
FAU - Wang, Yin
AU  - Wang Y
AD  - Institute for Translational Medicine, Qingdao University, Qing Dao, 266071, 
      China.
FAU - Li, Peifeng
AU  - Li P
AD  - Institute for Translational Medicine, Qingdao University, Qing Dao, 266071, 
      China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20190704
PL  - Netherlands
TA  - Ecotoxicol Environ Saf
JT  - Ecotoxicology and environmental safety
JID - 7805381
RN  - 0 (Environmental Pollutants)
RN  - 0 (Fluorocarbons)
SB  - IM
MH  - Animals
MH  - Environmental Exposure/adverse effects/*analysis
MH  - Environmental Pollutants/*analysis/toxicity
MH  - Fluorocarbons/*analysis/toxicity
MH  - Humans
MH  - Risk Assessment
OTO - NOTNLM
OT  - Contamination
OT  - PFAS alternatives
OT  - Potential impact
OT  - Risk assessment
OT  - Sources
OT  - Toxicity
EDAT- 2019/07/08 06:00
MHDA- 2019/10/18 06:00
CRDT- 2019/07/08 06:00
PHST- 2019/05/07 00:00 [received]
PHST- 2019/06/27 00:00 [revised]
PHST- 2019/06/29 00:00 [accepted]
PHST- 2019/07/08 06:00 [pubmed]
PHST- 2019/10/18 06:00 [medline]
PHST- 2019/07/08 06:00 [entrez]
AID - S0147-6513(19)30732-8 [pii]
AID - 10.1016/j.ecoenv.2019.109402 [doi]
PST - ppublish
SO  - Ecotoxicol Environ Saf. 2019 Oct 30;182:109402. doi: 
      10.1016/j.ecoenv.2019.109402. Epub 2019 Jul 4.