PMID- 31280398
OWN - NLM
STAT- MEDLINE
DCOM- 20200107
LR  - 20210110
IS  - 1437-7772 (Electronic)
IS  - 1341-9625 (Linking)
VI  - 24
IP  - 11
DP  - 2019 Nov
TI  - Clinical results of carbon-ion radiotherapy with separation surgery for primary 
      spine/paraspinal sarcomas.
PG  - 1490-1497
LID - 10.1007/s10147-019-01505-y [doi]
AB  - PURPOSE: To evaluate the clinical outcome of combination of carbon-ion 
      radiotherapy with separation surgery (CIRT-SS) in patients with primary 
      spinal/paraspinal sarcoma (PSPS) and epidural spinal cord compression (ESCC). 
      METHODS: CIRT-SS was performed in 11 consecutive patients. Patients treated in 
      the primary and salvage settings were categorized into Group A (n = 8) and Group 
      B (n  = 3), respectively. Clinical results and imaging findings were collected, 
      with a particular focus on ESCC grade, treatment-associated adverse events (AEs), 
      and the locoregional control (LRC) rate and overall survival (OS). RESULTS: The 
      median follow-up period from the start of CIRT-SS was 25 months (7-57 months). 
      ESCC was improved by SS in all cases. No patients exhibited radiation-induced 
      myelopathy (RIM), but three developed Grade 3 vertebral compression fracture 
      (VCF) during follow-up. Locoregional recurrences were observed in four patients 
      [Group A: 1 (12.5%), Group B: 3 (100%)]. Over the entire follow-up period, three 
      patients developed distant metastases and two patients died. The 2-year LRC rate 
      and OS were 70% and 80%, respectively. CONCLUSION: CIRT-SS in the primary setting 
      achieved acceptable LRC and OS without RIM in patients with PSPS and with ESCC. 
      VCF was the most frequent AE associated with CIRT-SS.
FAU - Matsumoto, Yoshihiro
AU  - Matsumoto Y
AUID- ORCID: 0000-0002-0039-2855
AD  - Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu 
      University, Fukuoka, 812-8582, Japan. ymatsu@ortho.med.kyushu-u.ac.jp.
FAU - Matsunobu, Akira
AU  - Matsunobu A
AD  - Ion Beam Therapy Center, SAGA HIMAT Foundation, Tosu, Japan.
FAU - Kawaguchi, Kenichi
AU  - Kawaguchi K
AD  - Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu 
      University, Fukuoka, 812-8582, Japan.
FAU - Hayashida, Mistumasa
AU  - Hayashida M
AD  - Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu 
      University, Fukuoka, 812-8582, Japan.
FAU - Iida, Keiichiro
AU  - Iida K
AD  - Department of Orthopaedic Surgery, Beppu Hospital, Kyushu University, Beppu, 
      Japan.
FAU - Saiwai, Hirokazu
AU  - Saiwai H
AD  - Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu 
      University, Fukuoka, 812-8582, Japan.
FAU - Okada, Seiji
AU  - Okada S
AD  - Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu 
      University, Fukuoka, 812-8582, Japan.
FAU - Endo, Makoto
AU  - Endo M
AD  - Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu 
      University, Fukuoka, 812-8582, Japan.
FAU - Setsu, Nokitaka
AU  - Setsu N
AD  - Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu 
      University, Fukuoka, 812-8582, Japan.
FAU - Fujiwara, Toshifumi
AU  - Fujiwara T
AD  - Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu 
      University, Fukuoka, 812-8582, Japan.
FAU - Baba, Shingo
AU  - Baba S
AD  - Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu 
      University, Fukuoka, Japan.
FAU - Nomoto, Satoshi
AU  - Nomoto S
AD  - Ion Beam Therapy Center, SAGA HIMAT Foundation, Tosu, Japan.
FAU - Nakashima, Yasuharu
AU  - Nakashima Y
AD  - Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu 
      University, Fukuoka, 812-8582, Japan.
LA  - eng
GR  - #18K09067/Grant-in-Aid for Scientific Research from the Japan Society for the 
      Promotion of Science/
PT  - Case Reports
PT  - Journal Article
DEP - 20190706
PL  - Japan
TA  - Int J Clin Oncol
JT  - International journal of clinical oncology
JID - 9616295
SB  - IM
MH  - Adult
MH  - Aged
MH  - Female
MH  - Fractures, Compression
MH  - Heavy Ion Radiotherapy/*adverse effects
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Recurrence, Local/etiology
MH  - Salvage Therapy
MH  - Sarcoma/mortality/*radiotherapy/*surgery
MH  - Spinal Cord Compression/etiology
MH  - Spinal Fractures/etiology
MH  - Spinal Neoplasms/mortality/*radiotherapy/*surgery
MH  - Treatment Outcome
MH  - Young Adult
OTO - NOTNLM
OT  - Carbon-ion radiotherapy
OT  - Epidural spinal cord compression
OT  - Primary spinal/paraspinal sarcoma
OT  - Separation surgery
OT  - Vertebral compression fracture
EDAT- 2019/07/08 06:00
MHDA- 2020/01/08 06:00
CRDT- 2019/07/08 06:00
PHST- 2019/05/30 00:00 [received]
PHST- 2019/07/01 00:00 [accepted]
PHST- 2019/07/08 06:00 [pubmed]
PHST- 2020/01/08 06:00 [medline]
PHST- 2019/07/08 06:00 [entrez]
AID - 10.1007/s10147-019-01505-y [pii]
AID - 10.1007/s10147-019-01505-y [doi]
PST - ppublish
SO  - Int J Clin Oncol. 2019 Nov;24(11):1490-1497. doi: 10.1007/s10147-019-01505-y. 
      Epub 2019 Jul 6.